Annual Reviews 2020: Recent advances in analytical sciences DOI Open Access
Sebastiaan Eeltink

Analytical Science Advances, Год журнала: 2021, Номер 2(3-4), С. 81 - 83

Опубликована: Апрель 1, 2021

This issue of Analytical Science Advances includes review papers written by authorities in the field, covering a wide range topics field analytical sciences. Authors were asked to provide critical discussing state-of-the-art their and highlight key developments applications literature published 2020. These reviews are ideally suited for those who want rapid overview latest advances particular learn about emerging applications. Mass spectrometry (MS) is an immensely important technology that still rapidly develops continues find new application areas. In on rise single-cell proteomics, Ctortecka Mechtler discuss current MS-based workflows. particular, aspects sample preparation when working with minute amounts samples discussed, possibilities separation science highlighted, MS quantification strategies including data postprocessing discussed. An capabilities high-resolution its applicability pharmaceutical analysis provided Géhin Holman. Rankin-Turner Heaney technological ambient ionization paper biomedical sciences, forensics security, food environment, chemical synthesis. The Hoffmann group summarizes imaging, focus approaches tissue-based imaging. Several covered science. De Vos et al. summarize UHPLC multi-dimensional LC instrument development recent Franchina reports instrumental comprehensive two-dimensional gas chromatography (GC × GC), hyphenation novel upstream or downstream processes. Major applied fields such as energy, fuel, foodstuff, plant, biological, environmental also covered. low molecular weight polar ionic components using ion (IC) coupled summarized Bruggink Jensen. Further IC hyphenated inductively plasma mass spectrometric detection reviewed. Muza described designing fabricating bioconjugated self-assembled polymer structures characterization flow fractionation. latter technique utilizes fluid dynamics external force effective separations at steady-state conditions within solvent filled channel. Finally, Eeltink reviewed organic polymer-based monolithic stationary phases. Other included this high-throughput experimentation (HTE), volatile flavor fragrance compounds, trends artificial intelligence, machine learning, chemometrics data. HTE growing evolving Vervoort considers throughput chromatographic spectroscopic techniques, well manipulation. compounds essential characterizing samples, oils, cosmetics. Louw techniques most frequently used 2020, which comprises assisted evaporation extraction, GC mobility spectrometry, electronic senses. Houhou Bocklitz intelligence based methods chemometrics, deep learning respect, inverse modeling, preprocessing methods, modeling spectra image various measurement allowing translate measurements can be full extent. Recently, launched "Art science" initiative, where we showcase artwork linked scientific publication.1, 2 For issue, I have approached Calissa Seelen from Caligrafix Productions her create artist impression different presented issue. obtained Bachelor Law Netherlands Master Sociology Belgium. She developed passion analyzing researching social inequality combines law sociology. After studies she worked European Union Agency Fundamental Rights Vienna (Austria). There experienced first-hand all amazing, life-changing, international research prestigious institute conducted did not reach common people EU. moving back Belgium, started Productions. Among others, creates digital illustrations, logos, layouts sole purpose improving communication between sender message receiver. Research findings extremely tool change world live today. One finding result impact many (daily) lives, without them even knowing how concept became reality. Figure 1 shows created Calissa. reasoning behind design explained illustrator: main idea me was illustration contains essence general subject journal, thematic areas specific operate. Through art image, wanted show humans interconnected through our interests, findings. state interconnectedness shown background image. It networking structure theory six degrees first researched Stanley Milgram his Small World Experiment,3 later referred groundwork theory. psychology widely other hypothesizes any person connected chain acquaintances has no more than five intermediaries average. represents need interdisciplinary collaboration researchers worldwide. dotted wave toward lighter area upper right corner efforts get out "dark" "unknowing" finally understanding, unity, equality among each other. Lastly, there molecules three-dimensional background, interfacing network structure, again small things study them. foreground every atom highlights special will explain meaning clockwise manner. situated top molecule Mechtler.4 simplified version human cell highlighting hunt proteome single modern proteomics used. literally light dark, target hunted decades now comes reach. second correlated Heaney,5 Holman,6 group.7 time-of-flight analysis, drifting vacuum detector. Upon detection, spectrum compound interest generated red. next showcases Louw.8 depicts diffuse air. shape strokes peaks up during in, example, GC. tinner red band string aromatic aiming discover. fourth inspired binary codes demonstrate following paper: Trends Bocklitz.9 fifth al.10 capillary column placed center considered heart analysis. Furthermore, it over course several core apparently changed lot (i.e., columns look exactly same) but so powerful definitely deserves highlighted. last peak pattern needs resolved al.11 three "overlapping" chromatograms information multiple dimensions required information. As whole, work these experts completes picture makes part illustration. Without innovations, fundamental knowledge chemistry life sciences could would lose value. By symbolizing unity advances, stress once importance multidisciplinary alliances, future discoveries. been great pleasure complete like thank contributors valuable time write excellent reviews. Clearly, progress being made direct society. am looking forward follow-up 2022 may include themes insights topics.

Язык: Английский

Proteomics Mass Spectrometry Data Analysis Tools DOI

Anjana Aji,

Nisha Reghu,

Muralidharan Vanuopadath

и другие.

Elsevier eBooks, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

0

Ion Mobility Mass Spectrometry: Instrumentation and Applications DOI Creative Commons
Orobola E. Olajide, Kimberly Y. Kartowikromo, Ahmed Hamid

и другие.

IntechOpen eBooks, Год журнала: 2023, Номер unknown

Опубликована: Дек. 16, 2023

The integration of ion mobility spectrometry with mass (as an IM-MS hybrid instrument) provides additional analytical separation and identification capabilities that have greatly advanced various fields, including biomedical, pharmaceutical, forensic sciences. In this chapter, a comprehensive exploration IMS instrumentation platforms is discussed, Drift tube (DTIMS), Traveling wave (TWIMS), Trapped (TIMS), Field asymmetric waveform (FAIMS), Differential analyzer (DMA). Their respective advantages limitations are evaluated in the context distinct applications, isomer separation, signal filtering to increase signal-to-noise ratio, collision cross section (CCS) measurements targeted untargeted omics-based workflows. scanning rate compatibility between devices different analyzers resulted hyphenation platforms. Higher sensitivity selectivity further achieved introduction tandem such as TIMS-TIMS-MS. separations occur millisecond range can therefore be easily incorporated into liquid chromatography-mass workflows coupled ambient ionization MS for metabolomics, lipidomic, proteomics, etc. emergence high-resolution instruments Cyclic Ion Mobility Spectrometry (cIMS) Structures lossless manipulations (SLIM) also discussed improvement isomers increased predictive accuracy CCS by machine learning models.

Язык: Английский

Процитировано

0

Deployable Mass Spectrometry for Rapid On-Site Bioanalysis DOI Open Access
Stephanie Rankin‐Turner, Liam M. Heaney

LCGC North America, Год журнала: 2022, Номер unknown, С. 14 - 18

Опубликована: Июль 1, 2022

Benchtop liquid chromatography (LC)–mass spectrometry (LC–MS) and benchtop gas chromatography–MS (GC–MS) have been the gold standard in bioanalysis for decades, employed clinical, forensic, anti-doping laboratories worldwide. However, traditional instrumentation is subject to limitations that severely restrict speed at which samples can be analyzed, ease with materials prepared, location where analysis must performed. With advent of ambient ionization portable mass spectrometers, ability perform rapid, on-site fast becoming a reality. Without need extensive sample preparation, times as low several seconds, remote from laboratory, deployable spectrometers potential revolutionize bioanalysis. challenges tackled before this innovative technology widely adopted.

Язык: Английский

Процитировано

0

Characterizing the Effects of Solvent and Analyte Properties on Ionization Efficiency by Novel Field-free and Field-enabled Ionization Techniques DOI

Kinkini Udara Jayasundara

Опубликована: Янв. 1, 2022

In recent years the mass spectrometry (MS) area of field and/or direct analysis has grown dramatically. As a result, field-portable and miniaturized spectrometers, introduced only few ago, are proliferating. A highly desired feature for MS, or in-field analysis, is ability to use ionization techniques requiring very little sample preparation as well an generate ions under ambient conditions. Recently, new technique termed vibrating sharp-edge spray (VSSI) been which overcomes limitations other spray-based methods including requirements auxiliary components (e.g., nebulizing gas high voltage). with significant potential analyses, it important that chemical physical properties VSSI be elucidated optimize ion production performance. Here, experimental theoretical studies provide insight into influence analyte solvent molecule on ions. Chapter 2, experiments employing protic solvents demonstrate different molecular associated increased compared gold standard electrospray (ESI) techniques; correlations observed intensity proton affinity polarity absent ESI. 3, acetonitrile also reveal difference between ESI techniques. For example, remarkably in positive mode, greater signals voltage-free Additionally, exhibits outsized relationship solvents. 4, dynamics (MD) simulations water droplets suggest energy desorption can account differences field-enabled VSSI. Further MD some support influencing efficiency. Finally, 5 provides direction improving hardware allow clear elucidation primary factors driving compound ionization.

Язык: Английский

Процитировано

0

Annual Reviews 2020: Recent advances in analytical sciences DOI Open Access
Sebastiaan Eeltink

Analytical Science Advances, Год журнала: 2021, Номер 2(3-4), С. 81 - 83

Опубликована: Апрель 1, 2021

This issue of Analytical Science Advances includes review papers written by authorities in the field, covering a wide range topics field analytical sciences. Authors were asked to provide critical discussing state-of-the-art their and highlight key developments applications literature published 2020. These reviews are ideally suited for those who want rapid overview latest advances particular learn about emerging applications. Mass spectrometry (MS) is an immensely important technology that still rapidly develops continues find new application areas. In on rise single-cell proteomics, Ctortecka Mechtler discuss current MS-based workflows. particular, aspects sample preparation when working with minute amounts samples discussed, possibilities separation science highlighted, MS quantification strategies including data postprocessing discussed. An capabilities high-resolution its applicability pharmaceutical analysis provided Géhin Holman. Rankin-Turner Heaney technological ambient ionization paper biomedical sciences, forensics security, food environment, chemical synthesis. The Hoffmann group summarizes imaging, focus approaches tissue-based imaging. Several covered science. De Vos et al. summarize UHPLC multi-dimensional LC instrument development recent Franchina reports instrumental comprehensive two-dimensional gas chromatography (GC × GC), hyphenation novel upstream or downstream processes. Major applied fields such as energy, fuel, foodstuff, plant, biological, environmental also covered. low molecular weight polar ionic components using ion (IC) coupled summarized Bruggink Jensen. Further IC hyphenated inductively plasma mass spectrometric detection reviewed. Muza described designing fabricating bioconjugated self-assembled polymer structures characterization flow fractionation. latter technique utilizes fluid dynamics external force effective separations at steady-state conditions within solvent filled channel. Finally, Eeltink reviewed organic polymer-based monolithic stationary phases. Other included this high-throughput experimentation (HTE), volatile flavor fragrance compounds, trends artificial intelligence, machine learning, chemometrics data. HTE growing evolving Vervoort considers throughput chromatographic spectroscopic techniques, well manipulation. compounds essential characterizing samples, oils, cosmetics. Louw techniques most frequently used 2020, which comprises assisted evaporation extraction, GC mobility spectrometry, electronic senses. Houhou Bocklitz intelligence based methods chemometrics, deep learning respect, inverse modeling, preprocessing methods, modeling spectra image various measurement allowing translate measurements can be full extent. Recently, launched "Art science" initiative, where we showcase artwork linked scientific publication.1, 2 For issue, I have approached Calissa Seelen from Caligrafix Productions her create artist impression different presented issue. obtained Bachelor Law Netherlands Master Sociology Belgium. She developed passion analyzing researching social inequality combines law sociology. After studies she worked European Union Agency Fundamental Rights Vienna (Austria). There experienced first-hand all amazing, life-changing, international research prestigious institute conducted did not reach common people EU. moving back Belgium, started Productions. Among others, creates digital illustrations, logos, layouts sole purpose improving communication between sender message receiver. Research findings extremely tool change world live today. One finding result impact many (daily) lives, without them even knowing how concept became reality. Figure 1 shows created Calissa. reasoning behind design explained illustrator: main idea me was illustration contains essence general subject journal, thematic areas specific operate. Through art image, wanted show humans interconnected through our interests, findings. state interconnectedness shown background image. It networking structure theory six degrees first researched Stanley Milgram his Small World Experiment,3 later referred groundwork theory. psychology widely other hypothesizes any person connected chain acquaintances has no more than five intermediaries average. represents need interdisciplinary collaboration researchers worldwide. dotted wave toward lighter area upper right corner efforts get out "dark" "unknowing" finally understanding, unity, equality among each other. Lastly, there molecules three-dimensional background, interfacing network structure, again small things study them. foreground every atom highlights special will explain meaning clockwise manner. situated top molecule Mechtler.4 simplified version human cell highlighting hunt proteome single modern proteomics used. literally light dark, target hunted decades now comes reach. second correlated Heaney,5 Holman,6 group.7 time-of-flight analysis, drifting vacuum detector. Upon detection, spectrum compound interest generated red. next showcases Louw.8 depicts diffuse air. shape strokes peaks up during in, example, GC. tinner red band string aromatic aiming discover. fourth inspired binary codes demonstrate following paper: Trends Bocklitz.9 fifth al.10 capillary column placed center considered heart analysis. Furthermore, it over course several core apparently changed lot (i.e., columns look exactly same) but so powerful definitely deserves highlighted. last peak pattern needs resolved al.11 three "overlapping" chromatograms information multiple dimensions required information. As whole, work these experts completes picture makes part illustration. Without innovations, fundamental knowledge chemistry life sciences could would lose value. By symbolizing unity advances, stress once importance multidisciplinary alliances, future discoveries. been great pleasure complete like thank contributors valuable time write excellent reviews. Clearly, progress being made direct society. am looking forward follow-up 2022 may include themes insights topics.

Язык: Английский

Процитировано

0