Nucleosides Nucleotides & Nucleic Acids,
Год журнала:
2024,
Номер
unknown, С. 1 - 18
Опубликована: Май 30, 2024
In
this
communication,
an
innovative
and
straightforward
protocol
for
the
one-pot
catalytic
synthesis
of
bis(indolyl)pyrimidine
derivatives
their
DNA
binding
abilities
is
presented.
The
involves
condensation
indole
with
diverse
substituted
pyrimidine-5-carbaldehydes,
employing
cost-effective
reusable
Sr-Al
supported
nanophosphors,
specifically
strontium
aluminate
(SrAl2O4),
as
a
catalyst.
particular,
method
does
not
require
use
toxic
solvents.
nanophosphorus
catalyst
exhibited
sustained
activity
over
multiple
cycles
showed
no
significant
decline
while
maintaining
its
strictly
heterogeneous
properties.
were
extensively
characterized
using
spectroscopic
analytical
techniques.
Furthermore,
interaction
between
these
CT-DNA
was
investigated
by
absorption
spectroscopy,
viscosity
measurement,
in
silico
molecular
docking
studies.
Photoinduced
cleavage
studies
demonstrated
photonuclease
compound
against
pUC19
upon
exposure
to
UV-visible
radiation.
Structural Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 24, 2025
Abstract
Curcumin
derivatives
are
bioactive
compounds
with
a
linear
structure
and
an
α,β-unsaturated
β-diketone
moiety.
The
chemical
reaction
of
3-hydroxy-4-methoxybenzaldehyde
cinnamaldehyde
in
DMF
the
presence
acetylacetone
boric
oxide
mixture
resulted
synthesis
curcumin
derivative
named
as
(1E,4Z,6E,8E)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-9-phenylnona-1,4,6,8-tetraen-3-one
(
HPTO
).
compound
was
characterized
by
FT-IR,
MS,
1H-,
13C-NMR.
Moreover,
crystal
determined
single
XRD
analysis,
which
displayed
solvent
molecule
along
main
geometry
stabilized
intramolecular
O–H···O
bonding.
adopted
non-planar
conformation
dihedral
angle
between
phenyl
rings
35.1
(1)°.
supramolecular
assembly
numerous
intermolecular
interactions
that
were
explored
Hirshfeld
surface
analysis.
Interaction
energy
calculations
carried
out
at
B3LYP/6-31
g(d,p)
electron
density
level
to
support
experimental
findings.
Void
analysis
performed
order
predict
response
applied
stress.
studied
using
DFT
method,
employing
6-311
basis
set,
evaluate
its
electronic
quantum
properties.
Frontier
molecular
orbitals
states
analyses
revealed
gap
3.08
eV.
This
finding
indicates
compound’s
significant
reactivity
potential
for
notable
biological
activity.
Molecular
docking
studies
cancer
treatment
medication
candidate.
By
multidisciplinary
methodology,
this
research
provides
thorough
understanding
structural
features,
properties,
prospective
pharmaceutical
applications,
paving
way
development
treatment.
Nucleosides Nucleotides & Nucleic Acids,
Год журнала:
2024,
Номер
unknown, С. 1 - 18
Опубликована: Май 30, 2024
In
this
communication,
an
innovative
and
straightforward
protocol
for
the
one-pot
catalytic
synthesis
of
bis(indolyl)pyrimidine
derivatives
their
DNA
binding
abilities
is
presented.
The
involves
condensation
indole
with
diverse
substituted
pyrimidine-5-carbaldehydes,
employing
cost-effective
reusable
Sr-Al
supported
nanophosphors,
specifically
strontium
aluminate
(SrAl2O4),
as
a
catalyst.
particular,
method
does
not
require
use
toxic
solvents.
nanophosphorus
catalyst
exhibited
sustained
activity
over
multiple
cycles
showed
no
significant
decline
while
maintaining
its
strictly
heterogeneous
properties.
were
extensively
characterized
using
spectroscopic
analytical
techniques.
Furthermore,
interaction
between
these
CT-DNA
was
investigated
by
absorption
spectroscopy,
viscosity
measurement,
in
silico
molecular
docking
studies.
Photoinduced
cleavage
studies
demonstrated
photonuclease
compound
against
pUC19
upon
exposure
to
UV-visible
radiation.
