Design, synthesis, molecular docking and antimicrobial evaluation of benzoylurea derivatives containing difluoromethyl (trifluoromethyl) pyrimidine DOI
Wenneng Wu,

Jiansong An,

Wenjun Lan

и другие.

Pest Management Science, Год журнала: 2024, Номер unknown

Опубликована: Дек. 13, 2024

Abstract BACKGROUND The reduction in agricultural product quality and yield caused by fungal bacterial plant diseases has led to considerable economic losses global crop production poses a threat human health. primary method of control remains the use chemical agents. In an effort develop novel highly effective antimicrobial agents, series benzoylurea derivatives incorporating difluoromethyl (trifluoromethyl) pyrimidine structure were designed synthesized. RESULTS this study, we synthesized containing fragments. Several compounds exhibited notable antifungal activity vitro against PS , CBC, BBC TBC. Their efficacy surpassed that positive controls HM Pyr. Notably, 6s demonstrated EC 50 value 4.10 μ g mL −1 significantly lower than 31.25 for antibacterial assays, also showed 87.49% inhibition rate Xoc . Moreover, vivo tests CBC revealed protective 59.39% at concentration 25 Molecular docking simulations further supported its strong activity. To explore mechanism action on conducted scanning electron microscopy, succinate dehydrogenase enzyme measurements dry weight, membrane permeability, cellular contents, ROS. CONCLUSION This study underscores potential fragments as lead management CBC. results offer important insights pave way development fungicides, contributing improved protection strategies agriculture. © 2024 Society Chemical Industry.

Язык: Английский

Advances in Coordination Chemistry of Schiff Base Complexes: A Journey from Nanoarchitectonic Design to Biomedical Applications DOI
Ahmad Abd‐El‐Aziz,

Zexuan Li,

Xinyue Zhang

и другие.

Topics in Current Chemistry, Год журнала: 2025, Номер 383(1)

Опубликована: Фев. 3, 2025

Язык: Английский

Процитировано

1

Salicylaldehyde-based Schiff bases and their transition metal complexes: an overview on synthesis and biological activities DOI
Md. Sohel Rana,

Noor Mohammad Azbar Rayhan,

Abu Hurayra Emad

и другие.

Journal of Coordination Chemistry, Год журнала: 2025, Номер unknown, С. 1 - 70

Опубликована: Март 24, 2025

Язык: Английский

Процитировано

0

Quantum–Chemical Study of the Photophysical Behavior of Mesogenic Europium(III) Complexes with β‐Diketones and Lewis Bases DOI Open Access
К А Романова, Yu. G. Galyametdinov

ChemistrySelect, Год журнала: 2024, Номер 9(41)

Опубликована: Окт. 29, 2024

Abstract Metal‐containing liquid crystals such as Ln(III) complexes possess unique structural, liquid‐crystalline (LC), optical, and magnetic properties represent modern cutting‐edge multifunctional materials. Application of mesogenic is hindered by their nontrivial structure–property relationships. These relationships, in turn, depend on various factors, including insufficiently studied physicochemical processes. Although a proper element the respective ligand environment are selected prior to synthesis complexes, structural features coordination polyhedra, especially upon photoexcitation, not uniquely defined. Therefore, this work focuses development theoretical approaches creating materials represented highly luminescent Eu(III) with β‐diketones Lewis bases. The relationships between structure, parameters Voronoi–Dirichlet luminescence efficiency, LC were considered. calculated excited states intramolecular energy transfer rates used determine channels. behavior was shown mainly environment, whereas optical found be mostly governed polyhedra.

Язык: Английский

Процитировано

1

A new Ni2+, Pd2+, and Pt2+ coordination compounds of carbothiohydrazide based chelating agent: Synthesis, characterization, crystal structure, DFT-TDFT calculations, antioxidant, and antimircrobial activities DOI
Amal A. Nassar, Ayman K. El‐Sawaf, El‐Sayed A. El‐Samanody

и другие.

Inorganic Chemistry Communications, Год журнала: 2024, Номер 170, С. 113405 - 113405

Опубликована: Ноя. 1, 2024

Язык: Английский

Процитировано

1

Design, synthesis, molecular docking and antimicrobial evaluation of benzoylurea derivatives containing difluoromethyl (trifluoromethyl) pyrimidine DOI
Wenneng Wu,

Jiansong An,

Wenjun Lan

и другие.

Pest Management Science, Год журнала: 2024, Номер unknown

Опубликована: Дек. 13, 2024

Abstract BACKGROUND The reduction in agricultural product quality and yield caused by fungal bacterial plant diseases has led to considerable economic losses global crop production poses a threat human health. primary method of control remains the use chemical agents. In an effort develop novel highly effective antimicrobial agents, series benzoylurea derivatives incorporating difluoromethyl (trifluoromethyl) pyrimidine structure were designed synthesized. RESULTS this study, we synthesized containing fragments. Several compounds exhibited notable antifungal activity vitro against PS , CBC, BBC TBC. Their efficacy surpassed that positive controls HM Pyr. Notably, 6s demonstrated EC 50 value 4.10 μ g mL −1 significantly lower than 31.25 for antibacterial assays, also showed 87.49% inhibition rate Xoc . Moreover, vivo tests CBC revealed protective 59.39% at concentration 25 Molecular docking simulations further supported its strong activity. To explore mechanism action on conducted scanning electron microscopy, succinate dehydrogenase enzyme measurements dry weight, membrane permeability, cellular contents, ROS. CONCLUSION This study underscores potential fragments as lead management CBC. results offer important insights pave way development fungicides, contributing improved protection strategies agriculture. © 2024 Society Chemical Industry.

Язык: Английский

Процитировано

0