We
report
a
novel
synthetic
procedure
for
making
analogues
of
the
widely
studied
ferroelectric
nematogen
RM734.
Our
new
focuses
on
building
materials
starting
from
nitro-terminus
and
eschewing
protecting
groups,
in
contrast
to
previously
reported
syntheses.
This
approach
confers
two
principal
advantages:
firstly,
synthesis
variants
described
herein
is
expedient,
being
single
step
as
opposed
three
or
more
via
classical
route.
Secondly,
by
forgoing
use
benzyl
groups
utilised
original
we
can
include
functionality
that
incompatible
with
hydrogenolysis
conditions
(e.g.
olefins,
late
halogens,
unsaturated
heterocycles).
Several
RM734-like
exhibit
nematic
phases,
rationalise
behaviour
these
aid
electronic
structure
calculations
potential
energy
surface
scans.
Liquid Crystals,
Год журнала:
2024,
Номер
unknown, С. 1 - 13
Опубликована: Фев. 21, 2024
This
paper
provides
guidance
for
the
rapid,
simple,
and
eco-friendly
synthesis
of
liquid
crystal
(LC)
molecules
using
hot-trend
mechanochemical
(MC)
in
community
organic
synthesis.
We
introduce
our
protocol,
which
may
guide
beginners
MC
technique
to
start
easy
quick
LC
molecules.
The
asks
no
need
a
complex
system
large
amount
solvent
like
conventional
solution-based
Additionally,
this
also
some
practical
examples
fast
screening
including
ferroelectric
nematic
(NFLC)
molecules,
are
subject
highly
hot
topics
field,
through
multi-step
PLoS ONE,
Год журнала:
2024,
Номер
19(12), С. e0313661 - e0313661
Опубликована: Дек. 12, 2024
The
biocompatibility
of
carborane
was
a
difficult
problem
that
had
drawn
lot
study
interest.
Using
multi-ion
inlay
binding,
water-soluble
polymers
were
created
by
encapsulating
nido
-carborane
in
diazaspirodecaniums
such
as
para-poly-
-carboanylazaspirodecanium
[5,4]
(p-PNC54),
[6,5]
(p-PNC65),
meta-poly-
(m-PNC54),
and
(m-PNC65).
First,
the
active
control
5-fluorouracil
demonstrated
strong
activity
against
HeLa
HCT-116
cells
but
minimal
cytotoxicity
at
19.22±2.85
μM
21.47±5.99
μM,
respectively.
Second,
four
specifically
penetrated
imaged
using
cells.
TEM
used
to
assess
dynamic
self-assembling
effect
these
order
gain
better
understanding
their
internal
microphenomenon.
All
derivatives’
combined
impacts
on
self-assembly
water
identified.
Different
degrees
selective
entrance
into
targeted
under
different
architectures
discovered
vitro
cell
imaging.
We
report
a
novel
synthetic
procedure
for
making
analogues
of
the
widely
studied
ferroelectric
nematogen
RM734.
Our
new
focuses
on
building
materials
starting
from
nitro-terminus
and
eschewing
protecting
groups,
in
contrast
to
previously
reported
syntheses.
This
approach
confers
two
principal
advantages:
firstly,
synthesis
variants
described
herein
is
expedient,
being
single
step
as
opposed
three
or
more
via
classical
route.
Secondly,
by
forgoing
use
benzyl
groups
utilised
original
we
can
include
functionality
that
incompatible
with
hydrogenolysis
conditions
(e.g.
olefins,
late
halogens,
unsaturated
heterocycles).
Several
RM734-like
exhibit
nematic
phases,
rationalise
behaviour
these
aid
electronic
structure
calculations
potential
energy
surface
scans.
