Phytoflavonoids as alternative therapeutic effect for melanoma: Integrative Network pharmacology, molecular dynamics and drug-likeness profiling for lead discovery

Computational Biology and Chemistry, Год журнала: 2025, Номер 117, С. 108390 - 108390

Опубликована: Фев. 22, 2025

Язык: Английский

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Target-specific high-throughput screening of anti-inflammatory phytosteroids for autoimmune diseases: A molecular docking-dynamics simulation approach

Steroids, Год журнала: 2025, Номер unknown, С. 109601 - 109601

Опубликована: Март 1, 2025

Язык: Английский

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Targeting EGFR-Mcl-1 Axis by Piperlongumine as a Novel Strategy for Non-Small Cell Lung Cancer Therapy

The American Journal of Chinese Medicine, Год журнала: 2025, Номер unknown, С. 1 - 23

Опубликована: Март 27, 2025

Non-small cell lung cancer (NSCLC) is a malignancy that faces serious resistance challenges in treatment. In this study, we identified Piperlongumine as promising therapeutic candidate to overcome Osimertinib NSCLC. We systematically investigated the inhibitory effect of on NSCLC cells and confirmed it could effectively inhibit vitro kinase activity wild-type (WT), exon 19 deletion, L858R/T790M-mutated EGFR. also found Piperlongumine-induced intrinsic apoptosis by interfering with EGFR signaling pathway, which was characterized down-regulation anti-apoptotic protein Mcl-1. Further mechanistic studies revealed degradation Mcl-1 dependent Akt-GSK3[Formula: see text] pathway. Additionally, Piperlongumine-promoted interaction between [Formula: text]-TRCP, thereby enhancing text]-TRCP-mediated ubiquitination Furthermore, significantly inhibited tumor growth both Osimertinib-sensitive resistant xenograft models. These findings highlight potential an effective agent overcoming EGFR-targeted therapy suggest new avenues for its clinical application

Язык: Английский

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Synthesis and biological evaluation of piperlongumine analogues containing indoline or tetrahydroquinoline as anticancer agents through apoptosis induction

Medicinal Chemistry Research, Год журнала: 2025, Номер unknown

Опубликована: Март 31, 2025

Язык: Английский

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Combination of Kaempferia galanga and Piper longum water extracts improves the antioxidant capability of myofibrillar protein

LWT, Год журнала: 2024, Номер unknown, С. 117191 - 117191

Опубликована: Дек. 1, 2024

Язык: Английский

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