A multifunctional natural treasure based on a “one stone, many birds” strategy for designing health-promoting applications: Tordylium apulum
Food Bioscience,
Год журнала:
2024,
Номер
62, С. 105088 - 105088
Опубликована: Сен. 10, 2024
Язык: Английский
Assessment of cytotoxic, apoptotic, enzyme inhibitory, and antioxidant properties, and phytochemical characterization of ethanolic extract from Cionura erecta
Food Bioscience,
Год журнала:
2025,
Номер
unknown, С. 106082 - 106082
Опубликована: Фев. 1, 2025
Язык: Английский
Biosynthesis of Phytochemical-Adorned Green Iron Oxide Nanoparticles Via Astragalus anisacanthus Extract and Evaluation of Biological Potentials
Journal of Inorganic and Organometallic Polymers and Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 10, 2025
Язык: Английский
Phytoconstituents of Hericium erinaceus Exert Benefits for ADHD Conditions by Targeting SLC6A4: Extraction, Spectroscopic Characterization, Phytochemical Screening, In Vitro, and Computational Perspectives
ACS Omega,
Год журнала:
2025,
Номер
10(5), С. 4261 - 4275
Опубликована: Янв. 31, 2025
Attention-deficit/hyperactivity
disorder
(ADHD)
is
a
persistent
neurodevelopmental
disorder.
Despite
pharmacological
interventions,
there
need
for
effective
lead
molecules
and
therapeutic
targets.
Recently,
Hericium
erinaceus
(HE)
has
been
traditionally
reported
to
treat
various
diseases.
Herein,
we
aimed
explore
the
noncytotoxic
properties,
phytochemical
composition,
spectroscopic
characterization
of
HE
aqueous
extract.
Additionally,
used
computational
workflows
identify
key
targets
ADHD
assess
extract
phytoconstituents
potential
targeting.
Initially,
was
obtained
using
Soxhlet
extraction,
its
cytotoxicity
assessed
on
SH-SY5Y
cells
MTT
assays.
FTIR
spectroscopy
characterized
extract's
functional
groups,
while
biochemical
methods
GC-MS
identified
constituents.
A
protein-protein
interaction
network
targets,
molecular
docking,
dynamics,
QM/MM
calculations
were
find
drug
candidates
from
As
result,
exhibited
no
in
across
concentrations
(0.625
10
μg/mL)
after
24
h.
analysis
detected
13
different
groups
that
hold
diverse
biological
importance.
Qualitative
screening
revealed
presence
carbohydrates,
flavonoids,
anthocyanins,
tannins,
alkaloids,
saponins,
steroids,
phenolic
compounds.
profiling
17
metabolites.
Simultaneously,
ADHD-related
genes
known
protein
integrated
into
network,
identifying
SLC6A4
as
hub
target.
Molecular
docking
compounds
showed
myo-inositol's
high
binding
efficiency
(-6.53
kcal/mol).
Dynamic
simulations
demonstrated
stable
interactions,
confirmed
ability
transfer
electrons,
reinforcing
potential.
Overall,
shows
potent
nontoxic
profile
contains
like
myo-inositol,
offering
promising
by
targeting
ADHD.
Язык: Английский
Investigation of Antioxidant, Antidiabetic, and Antiglycation Properties of Sonchus oleraceus and Lobularia maritima (L.) Desv. Extracts from Taza, Morocco
Food Chemistry Advances,
Год журнала:
2025,
Номер
unknown, С. 100912 - 100912
Опубликована: Фев. 1, 2025
Язык: Английский
Phytochemical Analysis and Biological Activities of Leiotulus aureus Extracts: Antioxidant, Anticholinesterase, Antidiabetic, and Antidepressant Properties
Process Biochemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Язык: Английский
LC‐HRMS Profiling of Phytochemicals with Assessment of Antioxidant, Anticholinesterase, and Antimicrobial Potentials of Astragalus brachystachys DC
Chemistry & Biodiversity,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 14, 2024
Abstract
Astragalus
species
are
ubiquitous
in
the
pharmacopeia
of
numerous
countries,
signifying
their
widespread
medicinal
applications.
Türkiye
is
esteemed
as
one
principal
epicenters
diversity
for
this
genus
with
483
taxa,
and
many
these
plants
have
been
traditionally
utilized
diseases
including
coughing,
diabetes,
cardiovascular
disorders,
aches.
Although
there
a
considerable
body
chemical
biological
research
available
on
several
species,
studies
focusing
brachystachys
DC
exceedingly
rare.
In
context,
This
study
provides
first
comprehensive
report
plant
constituents
activities
an
important
plant,
DC.
The
aerial
part
samples
were
collected
from
Adana,
Türkiye,
ethanol
extract
was
prepared
parts.
secondary
metabolites
determined
by
LC‐HRMS
analysis.
analysis
showed
presence
39
different
constituents,
hyperoside
(303.419±10.50
μg/g
extract),
p‐
coumaric
acid
(256.975±8.51
rutin
(72.684±2.23
extract)
major
compounds
parts
extract.
Attributed
to
its
high
total
phenolic
(58.53±1.30
μg
PEs/mg
flavonoid
content
(29.98±0.83
QEs/mg
demonstrated
strong
antioxidant
activity
according
three
assays
namely
DPPH
free
(IC
50
:
33.08±0.61
μg/mL),
ABTS
cation
radical
scavenging
15.39±0.72
μg/mL)
CUPRAC
(A
0.5
36.25±0.28
methods.
vitro
that
cholinesterase
inhibitory
results
found
be
exceptional
85.95±0.52
%
inhibition
acetylcholinesterase
66.32±1.33
butyrylcholinesterase
at
200
μg/mL.
Regarding
antimicrobial
properties,
effective
against
Enterococcus
faecalis
MIC
value
39.06
Язык: Английский