Antimicrobial Potential of Scorpion-Venom-Derived Peptides DOI Creative Commons
Zhiqiang Xia, Lixia Xie, Bing Li

и другие.

Molecules, Год журнала: 2024, Номер 29(21), С. 5080 - 5080

Опубликована: Окт. 27, 2024

The frequent and irrational use of antibiotics by humans has led to the escalating rise antimicrobial resistance (AMR) with a high rate morbidity-mortality worldwide, which poses challenge development effective treatments. A large number host defense peptides from different organisms have gained interest due their broad antibacterial spectrum, rapid action, low target resistance, implying that these natural sources might be new alternative drugs. As important effectors prey capture, against other animal attacks, competitor deterrence, scorpion venoms been developed as candidate for modern drug development. With progress bioanalytical throughput sequencing techniques, more scorpion-venom-derived peptides, including disulfide-bridged (DBPs) non-disulfide-bridged (NDBPs), recently identified having massive pharmacological activities in channelopathies, pathogen infections, cancer In this review, we summarize molecular diversity corresponding structural classification venom antibacterial, antifungal, and/or antiparasitic activity. We also aim improve understanding underlying mechanisms exert functions, finally highlight key aspects prospects therapeutic or pharmaceutical application.

Язык: Английский

Determining the Usefulness of Selected Laboratory Markers of Inflammation in Qualifying Patients for T2 Biosystems Determination DOI Creative Commons
Mateusz Szymański, Małgorzata M. Skiba, Małgorzata Piasecka

и другие.

Journal of Clinical Laboratory Analysis, Год журнала: 2025, Номер unknown

Опубликована: Март 27, 2025

ABSTRACT Background Improving treatment outcomes sepsis requires early recognition, the implementation of appropriate treatment, and targeted antimicrobial therapy. Nowadays, microbiological diagnostic methods are available to accelerate diagnosis, thereby reducing time needed implement antibiotic One method for rapid diagnosis is amplified magnetic resonance imaging—T2 Biosystems, USA (T2Dx). This enables identification pathogens directly from a blood sample (approximately 4 mL) within about 3.5 h. The use “T2 Resistance” panel additionally allows detection most common bacterial resistance mechanisms in 4–5 disadvantage T2Dx limited number microorganisms it can detect. objective study was evaluate effectiveness using selected inflammatory parameters accurately qualify patients (positive result) testing. Methods We have made retrospective evaluation order determine which best indicators good qualification patients. Results Conclusion A single analysis such as C‐reactive protein (CRP), white cells (WBC), #neutr, #lymph, neutrophil‐to‐lymphocyte ratio (NLR) not indicator that could be used an additional tool facilitating patient sensitive parameter distinguishing between with positive result those negative measurement IL‐6 PCT. Proper testing significantly contribute initiate therapy may impact mortality improving long‐term outcomes.

Язык: Английский

Процитировано

0
Indole derivatives display antimicrobial and antibiofilm effects against extensively drug-resistant Acinetobacter baumannii DOI Creative Commons

Junwei Li,

Lulin Xie,

Fei Lin

и другие.

Microbiology Spectrum, Год журнала: 2025, Номер unknown

Опубликована: Апрель 15, 2025

ABSTRACT Acinetobacter baumannii is a critical priority gram-negative bacterial species featured with multidrug resistance and biofilm formation. This study screened 46 indole derivative agents for their antimicrobial activities against clinical isolates of extensively drug-resistant A. (XDRAB) various degrees production. Three selected agents—5-iodoindole, 3-methylindole, 7-hydroxyindole—were revealed to display potent antibiofilm activity, including synergistic interplay anti- A . drugs XDRAB. Sub-inhibitory concentrations these (particularly 7-hydroxyindole at 1/64 MIC) not only inhibited XDRAB formation but also eradicated the mature biofilm. The survival rate XDRAB-infected Galleria mellonella was improved treatment 7-hydroxyindole. Mechanistically, found reduce expression quorum sensing/biofilm-implicated genes abaI abaR Together, findings highlight potential derivatives infections. IMPORTANCE Extensively pose major public health threat therapy are highly prevalent in hospital settings. identified characterized such as can both inhibit eradicate Indole warrant further investigation hard-to-treat antimicrobial-resistant pathogens.

Язык: Английский

Процитировано

0
Antimicrobial Potential of Scorpion-Venom-Derived Peptides DOI Creative Commons
Zhiqiang Xia, Lixia Xie, Bing Li

и другие.

Molecules, Год журнала: 2024, Номер 29(21), С. 5080 - 5080

Опубликована: Окт. 27, 2024

The frequent and irrational use of antibiotics by humans has led to the escalating rise antimicrobial resistance (AMR) with a high rate morbidity-mortality worldwide, which poses challenge development effective treatments. A large number host defense peptides from different organisms have gained interest due their broad antibacterial spectrum, rapid action, low target resistance, implying that these natural sources might be new alternative drugs. As important effectors prey capture, against other animal attacks, competitor deterrence, scorpion venoms been developed as candidate for modern drug development. With progress bioanalytical throughput sequencing techniques, more scorpion-venom-derived peptides, including disulfide-bridged (DBPs) non-disulfide-bridged (NDBPs), recently identified having massive pharmacological activities in channelopathies, pathogen infections, cancer In this review, we summarize molecular diversity corresponding structural classification venom antibacterial, antifungal, and/or antiparasitic activity. We also aim improve understanding underlying mechanisms exert functions, finally highlight key aspects prospects therapeutic or pharmaceutical application.

Язык: Английский

Процитировано

2