A review of recent advances in anticancer activity and SAR of pyrazole derivatives DOI

Heba A. Hofny,

Mamdouh F. A. Mohamed, Heba A. Hassan

и другие.

Archiv der Pharmazie, Год журнала: 2025, Номер 358(3)

Опубликована: Март 1, 2025

Abstract The present review serves to highlight the antitumor worth of pyrazole derivatives. Several active pyrazole‐based anticancer compounds proposed by a huge number scientists worldwide are reported. Regarding development novel agents at faster tone, there is need correlate latest information with previously available understand situation this moiety in drug discovery studies. Herein, different pyrazoles classified according their mode action targets. results provided evidence that derivatives have potential applications for treatment variety tumor types. From study's findings, structure–activity relationship (SAR) demonstrated all containing substituted represent an important scaffold activities. Publications area increasing, and therefore, new therapeutic involving members could be discovered near future, as many prospects not been sufficiently studied so far other In words, provides overview state knowledge about structural characteristics most recent SAR various This will allow medicinal chemists identify promising structures guide design synthesis more effective safer candidates.

Язык: Английский

A review of recent advances in anticancer activity and SAR of pyrazole derivatives DOI

Heba A. Hofny,

Mamdouh F. A. Mohamed, Heba A. Hassan

и другие.

Archiv der Pharmazie, Год журнала: 2025, Номер 358(3)

Опубликована: Март 1, 2025

Abstract The present review serves to highlight the antitumor worth of pyrazole derivatives. Several active pyrazole‐based anticancer compounds proposed by a huge number scientists worldwide are reported. Regarding development novel agents at faster tone, there is need correlate latest information with previously available understand situation this moiety in drug discovery studies. Herein, different pyrazoles classified according their mode action targets. results provided evidence that derivatives have potential applications for treatment variety tumor types. From study's findings, structure–activity relationship (SAR) demonstrated all containing substituted represent an important scaffold activities. Publications area increasing, and therefore, new therapeutic involving members could be discovered near future, as many prospects not been sufficiently studied so far other In words, provides overview state knowledge about structural characteristics most recent SAR various This will allow medicinal chemists identify promising structures guide design synthesis more effective safer candidates.

Язык: Английский

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