A decade of research effort in synthesis, biological activity assessments, and mechanistic investigations of sulfamethazine‐incorporating molecules DOI
Hamada S. Abulkhair, Khaled El‐Adl

Archiv der Pharmazie, Год журнала: 2025, Номер 358(3)

Опубликована: Март 1, 2025

Abstract Because of its importance in medicinal chemistry, scientific researchers have been interested incorporating sulfamethazine developing biologically active candidates. To achieve this, several synthetic approaches adopted. The adopted included condensation with electrophilic reactants, coupling nucleophilic aromatics and methylene compounds, Knoevenagel condensation, Doebner Miller reaction, microwave‐assisted click cycloaddition, green reaction routes, multicomponent reaction. Linking this molecular scaffold to a variety heterocycles the last 10 years furnished set potential anti‐inflammatory, antiviral, anticancer, antiparkinsonian, neuroprotective, antidiabetic candidates targeting H5N1 NA, epidermal growth factor receptor, acetylcholinesterase (AChE), butylcholinesterase (BChE), human carbonic anhydrase ( h CA), α‐amylase, α‐glucosidase. This review reports all approaches, biological activities studied, structure‐activity relationship analyses, mechanistic investigations reported organic sulfamethazine‐incorporating molecules throughout 2015–2024, based on information retrieved from three search engines: Scopus, PubMed, Google Scholar.

Язык: Английский

A decade of research effort in synthesis, biological activity assessments, and mechanistic investigations of sulfamethazine‐incorporating molecules DOI
Hamada S. Abulkhair, Khaled El‐Adl

Archiv der Pharmazie, Год журнала: 2025, Номер 358(3)

Опубликована: Март 1, 2025

Abstract Because of its importance in medicinal chemistry, scientific researchers have been interested incorporating sulfamethazine developing biologically active candidates. To achieve this, several synthetic approaches adopted. The adopted included condensation with electrophilic reactants, coupling nucleophilic aromatics and methylene compounds, Knoevenagel condensation, Doebner Miller reaction, microwave‐assisted click cycloaddition, green reaction routes, multicomponent reaction. Linking this molecular scaffold to a variety heterocycles the last 10 years furnished set potential anti‐inflammatory, antiviral, anticancer, antiparkinsonian, neuroprotective, antidiabetic candidates targeting H5N1 NA, epidermal growth factor receptor, acetylcholinesterase (AChE), butylcholinesterase (BChE), human carbonic anhydrase ( h CA), α‐amylase, α‐glucosidase. This review reports all approaches, biological activities studied, structure‐activity relationship analyses, mechanistic investigations reported organic sulfamethazine‐incorporating molecules throughout 2015–2024, based on information retrieved from three search engines: Scopus, PubMed, Google Scholar.

Язык: Английский

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