Pharmaceutics,
Год журнала:
2024,
Номер
16(5), С. 655 - 655
Опубликована: Май 14, 2024
A
visual
Raman
nano-delivery
system
(NS)
is
a
widely
used
technique
for
the
visualization
and
diagnosis
of
tumors
various
biological
processes.
Thiophene-based
organic
polymers
exhibit
excellent
biocompatibility,
making
them
promising
candidates
development
as
NS.
However,
materials
based
on
thiophene
face
limitations
due
to
their
absorption
spectra
not
matching
with
NIR
(near-infrared)
excitation
light,
which
makes
it
difficult
achieve
enhanced
properties
also
introduces
potential
fluorescence
interference.
In
this
study,
we
introduce
donor–acceptor
(D-A)-structured
thiophene-based
polymer,
PBDB-T.
Due
D-A
molecular
modulation,
PBDB-T
exhibits
narrow
bandgap
Eg
=
2.63
eV
red-shifted
spectrum,
edge
extending
into
region.
Upon
optimal
785
nm
achieves
ultra-strong
pre-resonant
enhancement
while
avoiding
As
an
intrinsically
sensitive
NS
in
vivo
imaging,
enables
microtumor
regions
dimensions
0.5
mm
×
0.9
mm,
successfully
diagnoses
deeper
tumor
tissues,
circulation
half-life
14.5
h.
This
research
unveils
application
excited
diagnosis,
introducing
new
platform
advancement
“Visualized
Drug
Delivery
Systems”.
Moreover,
aforementioned
more
diverse
range
targeted
drug
delivery
methods,
can
be
tailored
specific
regions.
Journal of Nanobiotechnology,
Год журнала:
2023,
Номер
21(1)
Опубликована: Май 6, 2023
Abstract
Surface-Enhanced
Raman
Scattering
(SERS)
technology,
as
a
powerful
tool
to
identify
molecular
species
by
collecting
spectral
signals
at
the
single-molecule
level,
has
achieved
substantial
progresses
in
fields
of
environmental
science,
medical
diagnosis,
food
safety,
and
biological
analysis.
As
deepening
research
is
delved
into
SERS
sensing,
more
high-performance
or
multifunctional
substrate
materials
emerge,
which
are
expected
push
sensing
application
fields.
Especially
field
analysis,
intrinsic
extrinsic
schemes
have
been
widely
used
explored
due
their
fast,
sensitive
reliable
advantages.
Herein,
recent
developments
substrates
applications
biomolecular
detection
(SARS-CoV-2
virus,
tumor
etc.),
imaging
pesticide
summarized.
The
concepts
(including
its
basic
theory
mechanism)
important
strategies
(extending
from
nanomaterials
with
tunable
shapes
nanostructures
surface
bio-functionalization
modifying
affinity
groups
specific
biomolecules)
for
improving
biosensing
performance
comprehensively
discussed.
For
data
analysis
identification,
machine
learning
methods
software
acquisition
sources
diagnosing
discussed
detail.
In
conclusion,
challenges
perspectives
future
presented.
Diagnostics,
Год журнала:
2023,
Номер
13(5), С. 833 - 833
Опубликована: Фев. 22, 2023
In
recent
years,
there
has
been
an
increasing
interest
in
using
nanoparticles
the
medical
sciences.
Today,
metal
have
many
applications
medicine
for
tumor
visualization,
drug
delivery,
and
early
diagnosis,
with
different
modalities
such
as
X-ray
imaging,
computed
tomography
(CT),
magnetic
resonance
imaging
(MRI),
positron
emission
(PET),
etc.,
treatment
radiation.
This
paper
reviews
findings
of
nanotheranostics
therapy.
The
study
offers
some
critical
insights
into
types
cancer
detection
purposes.
data
this
review
were
gathered
from
multiple
scientific
citation
websites
Google
Scholar,
PubMed,
Scopus,
Web
Science
up
through
end
January
2023.
literature,
are
used
applications.
However,
due
to
their
high
abundance,
low
price,
performance
visualization
treatment,
gold,
bismuth,
tungsten,
tantalum,
ytterbium,
gadolinium,
silver,
iron,
platinum,
lead
investigated
study.
highlighted
importance
iron-based
forms
ease
functionalization,
toxicity,
superior
biocompatibility.
Arabian Journal of Chemistry,
Год журнала:
2024,
Номер
17(4), С. 105650 - 105650
Опубликована: Янв. 24, 2024
Gold
nanoparticles
(AuNPs)
exhibit
promising
potential
as
medical
materials
due
to
their
high
biocompatibility,
tunable
size
and
shape,
excellent
drug
delivery
capabilities,
among
other
unique
physicochemical
properties.
Previous
studies
have
indicated
the
remarkable
anti-inflammatory
activity
of
ginsenoside
compound
K
(CK).
However,
relatively
low
bioavailability
CK
restricts
its
effective
action
within
biological
system.
Hence,
exploring
novel
methods
based
on
gold
emerges
a
strategy
overcome
these
challenges
in
application,
thereby
enhancing
therapeutic
effectiveness
CK.
Probiotic-mediated
AuNPs
were
synthesized
using
salt
lysates
Bifidobacterium
animalis
subsp.
lactis.
Then,
was
loaded
with
form
(Bifi-CKAuNPs).
The
Bifi-CKAuNPs
evaluated
vitro
RAW
264.7
cells
vivo
mice.
NF-κB/
mitogen-activated
protein
kinases
(MAPK)
pathway
investigated
mechanism
action.
In
experiments
showed
that
inhibited
activation
reactive
oxygen
species
reduced
expression
iNOS,
COX-2,
pro-inflammatory
cytokines
(IL-1β,
IL-6,
TNF-α)
cells.
significantly
inflammation
lung,
kidney,
liver
tissues
mice
without
toxicity.
mediated
through
inhibition
NF-κB/MAPK
signal
transduction,
which
is
well-known
critical
pathogenesis
inflammation.
We
successfully
characterized
Bifi-AuNPs,
demonstrating
potent
both
vivo.
Our
results
might
play
key
role
Bifi-CKAuNPs.
These
findings
underscored
significant
platform
for
therapy.
observed
efficacy
cellular
animal
models,
along
insights
into
underlying
molecular
pathways,
positions
valuable
candidate
advancing
strategies
realm
management.
Chemosensors,
Год журнала:
2023,
Номер
11(2), С. 110 - 110
Опубликована: Фев. 3, 2023
Precision
cancer
medicine
necessitates
a
personalized
treatment
plan
for
each
individual
patient.
Given
cancer’s
heterogeneity
and
dynamic
nature,
the
plot
of
patient-specific
signatures
composed
multiple
circulating
biomarkers
is
useful
to
reveal
complete
tumor
landscape
guiding
precision
medicine.
As
an
emerging
new
technology,
surface-enhanced
Raman
scattering
(SERS)
shows
intrinsic
advantage
performing
multiplexed
detection
with
extremely
narrow
spectral
line
widths.
In
this
review,
we
first
discuss
design
principle
SERS
nanotags
enable
biomarkers,
highlighting
important
roles
plasmonic
nanostructures
triple
bond-modulated
reporters.
Following
this,
detail
use
isotropic
anisotropic
as
enhancement
substrates
amplifying
signals
in
multi-biomarker
detection.
Furthermore,
present
molecules
reporters
expand
multiplexing
capability
biomarker
measurements.
Finally,
offer
critical
insights
into
challenges
perspectives
diagnosis,
particularly
from
aspect
future
clinical
transition.
It
expected
that
review
can
facilitate
more
functional
high
sensitivity
assist
early
accurate
screening.
We
also
believe
our
will
be
interest
fields
molecular
imaging,
biomedicine,
analytical
chemistry.
Russian Chemical Reviews,
Год журнала:
2022,
Номер
91(10), С. RCR5058 - RCR5058
Опубликована: Окт. 1, 2022
Plasmonic
particles
represent
a
rapidly
developing
material
for
nanotechnology.
They
are
used
in
biomedicine
as
sensoric,
diagnostic
and
therapeutic
agents.
Most
theranostic
applications
exploit
the
unique
optical
properties
of
gold
or
hybrid
nanoparticles
which
visible
near-infrared
light
excites
localized
plasmon
resonances.
The
review
discusses
latest
advances
synthesis
most
popular
sought-after
such
nanospheres,
nanorods,
nanoshells,
nanocages
nanostars
also
gold–silver
nanorods
nanocuboids.
consideration
is
focused
on
design
principles
particle
size,
shape
structure,
provides
desired
tuning
resonance
wavelength
absorption
scattering
cross-sections.
optimal
parameters
use
photothermal
photodynamic
therapy,
surface-enhanced
Raman
catalysis
discussed.
<br>
bibliography
includes
294
references.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Фев. 26, 2024
Abstract
The
capacity
to
identify
small
amounts
of
pathogens
in
real
samples
is
extremely
useful.
Herein,
we
proposed
a
sensitive
platform
for
detecting
using
cyclic
DNA
nanostructure@AuNP
tags
(CDNA)
and
cascade
primer
exchange
reaction
(cPER).
This
employs
wheat
germ
agglutinin-modified
Fe
3
O
4
@Au
magnetic
nanoparticles
(WMRs)
bind
the
E.
coli
O157:H7,
then
triggers
cPER
generate
branched
products
CDNA
tag
hybridization
with
high
stability
amplified
SERS
signals.
It
can
target
as
low
1.91
CFU/mL
discriminate
O157:H7
complex
such
water,
milk,
serum,
demonstrating
comparable
or
greater
sensitivity
accuracy
than
traditional
qPCR.
Moreover,
developed
detect
levels
mouse
allowing
discrimination
mice
early-stage
infection.
Thus,
this
holds
promise
food
analysis
early
infection
diagnosis.
Bulletin of the Chemical Society of Japan,
Год журнала:
2024,
Номер
97(7)
Опубликована: Июль 1, 2024
Abstract
Sophisticated
control
of
the
spatial
arrangement
gold
nanorods
provides
significant
advantages
in
design
plasmonic
systems.
However,
dynamic
modulation
nanorod
arrangements
remains
challenging.
Here,
we
present
a
novel
strategy
for
thermo-responsive
with
uniform
alignment
on
solid
substrate
using
polymer
brushes.
In
this
system,
cationic
and
were
immobilized
into
anionic
brushes
via
moderate
electrostatic
interactions,
providing
vertically
aligned
arrays.
Upon
heating,
assembled
while
maintaining
their
vertical
orientation
within
They
returned
to
original
state
upon
cooling,
indicating
reversible
assembly/disassembly.
It
is
noticeable
that
system
exhibits
rapid
changes
nanostructure
even
when
brush
rather
than
those
dispersed
solution.
Importantly,
showed
good
adhesion
stability
without
any
detachment
during
washing
thermal
cycling
processes
but
performed
assembly
formation
at
largely
separated
conditions,
traveling
considerable
distances
similar
lateral
diffusion
membrane
proteins
cell
membranes.
addition
unprecedented
over
configurations,
our
approach
introduces
versatile
platform
developing
advanced
devices.
