Transition metal-free C(sp³)–H selenation of β-ketosulfones

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(10), С. 2075 - 2080

Опубликована: Янв. 1, 2024

Direct C(sp 3 )-H selenation, which is most atom economical, remains a formidable challenge, and only few examples have been reported to date. In this article, we introduce the transition metal-free selenation with β-ketosulfones diselenides as material source.

Язык: Английский

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Benzylic C(sp³)−H Alkoxylation through Visible‐Light‐Driven Oxidative Radical‐Polar Crossover

Asian Journal of Organic Chemistry, Год журнала: 2024, Номер 13(4)

Опубликована: Фев. 8, 2024

Abstract We report a metal‐free method for benzylic C(sp 3 )−H alkoxylation with silyl ether as an alkoxylating agent. The reaction is considered to proceed through sequence consisting of hydrogen atom transfer (HAT) and oxidative radical‐polar crossover, wherein Selectfluor serves one‐electron oxidant, HAT agent, fluoride ion source. formed in situ activates the give alkoxide nucleophile, which reacts benzyl cation intermediate provide product. present protocol has broad substrate scope, enabling C−H primary, secondary, tertiary bonds. Furthermore, it applicable late‐stage bioactive molecules.

Язык: Английский

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Ag/Au-Catalyzed Functionalization of Heterocycles Through C–H Activation

Topics in heterocyclic chemistry, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Язык: Английский

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