Research Progress of Homogeneous Catalytic Reactions of Hexafluoroisopropanol (HFIP)
Tetrahedron Green Chem,
Год журнала:
2025,
Номер
5, С. 100071 - 100071
Опубликована: Фев. 27, 2025
Язык: Английский
para-Selective C-H Functionalization of Anilines: A Review
Fatemeh Doraghi,
Yasin Mohammadkhani Kalooei,
Negar Mehdi zadeh Darban
и другие.
Journal of Organometallic Chemistry,
Год журнала:
2024,
Номер
1019, С. 123313 - 123313
Опубликована: Авг. 16, 2024
Язык: Английский
Iron-Catalyzed Cross-Dehydrogenative Coupling of para-Quinone Methides with Formamides: In Situ Activation of C(sp2)–H Bonds
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(22), С. 16663 - 16678
Опубликована: Ноя. 1, 2024
A
novel
and
straightforward
method
for
the
iron-catalyzed
regioselective
cross-dehydrogenative
coupling
of
para-quinone
methides
(p-QMs)
with
formamides
has
been
developed,
facilitated
by
in
situ
activation
C(sp2)–H
bonds
formyl
alkenyl
substituents
via
a
radical
strategy.
This
does
not
require
preactivation
substrates,
it
can
accommodate
wide
range
p-QMs
under
optimized
reaction
conditions,
resulting
formation
expected
C-7
acetamides-functionalized
moderate
to
good
yields.
The
control
experiments
revealed
that
follows
fundamental
equation
second-order
kinetics.
Additionally,
an
exploration
Hammett
effect
was
undertaken
elucidate
impact
reaction.
In
combination
DFT
calculation,
plausible
mechanism
proposed
through
meticulously
controlled
experiments.
Язык: Английский
Copper‐Catalyzed Regioselective Cyanation/Diarylmethylation of Formamides: Construction of α‐Cyano Functionalized Tetra‐Substituted Olefins
Chinese Journal of Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 14, 2024
Comprehensive
Summary
A
copper‐catalyzed
cyanation/diarylmethylation
of
formamides
has
been
developed
for
the
synthesis
α‐cyano
functionalized
tetra‐substituted
olefins
by
utilizing
para
‐quinone
methides
(
p
‐QMs)
and
trimethylcyanosilane
as
functionalization
sources.
Various
kinds
‐QMs
are
well
tolerated,
delivering
desired
products
with
72%—94%
yields,
demonstrating
broad
functional
group
tolerance.
Notably,
reaction
does
not
require
noble
metals
proceeds
regioselectively
under
mild
conditions.
Based
on
step‐by‐step
control
experiments,
Hammett
studies
DFT
calculation,
a
plausible
mechanism
is
proposed.
Язык: Английский