Introducing of an Unexplored Aza-BODIPY Diradicaloids with 4-(2,6-Ditert-butyl)phenoxyl Radicals Located in 1,7-Positions of the Aza-BODIPY Core
Inorganic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 27, 2024
We
have
prepared
and
characterized
two
diradicaloid
systems
5a
5b
that
originated
from
the
oxidation
of
a
1,7-(4-(2,6-di-tert-butyl)phenol)-substituted
aza-BODIPY
core.
The
diradicaloids
were
by
large
array
experimental
computational
methods.
diamagnetic
closed-shell
state
was
postulated
as
ground
in
solution
solid-state
with
substantial
thermal
population
originating
both
open-shell
diradical
triplet
states
observed
at
room
temperature.
Transient
absorption
spectroscopy
indicates
fast
(<10
ps)
excited
deactivation
pathways
associated
target
compounds'
character
Variable-temperature
1H
NMR
spectra
indicate
solvent
dependency
5b.
could
be
stepwise
reduced
to
mixed-valence
radical-anion
dianion
upon
consequent
single-electron
reductions.
Similarly,
deprotonated
aza-BODIPYs
can
oxidized
form.
Both
dianionic
forms
exhibit
an
intense
NIR
region.
Density
functional
theory
(DFT)
time-dependent
DFT
calculations
used
explain
transformations
UV–Vis-NIR
all
compounds.
Язык: Английский
Strategic Modifications in Aza-BODIPYs: The Role of Ferrocene and Metal Coordination in Enhancing Absorptivity and Redox Behavior
Journal of Molecular Structure,
Год журнала:
2025,
Номер
unknown, С. 141801 - 141801
Опубликована: Фев. 1, 2025
Язык: Английский
N, O - Chelate Fluoroborane Dyes: Synthesis, Optical Properties in Dual Aggregate State
Journal of Fluorescence,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 23, 2025
Язык: Английский
Advancements in Nanocarrier Delivery Systems for Photodynamic Therapy in Lung Cancer
International Journal of Nanomedicine,
Год журнала:
2025,
Номер
Volume 20, С. 6853 - 6874
Опубликована: Май 1, 2025
Photodynamic
therapy
(PDT),
as
a
non-invasive
treatment
modality,
has
shown
potential
an
alternative
to
traditional
therapies
in
lung
cancer
treatment.
However,
its
clinical
application
is
still
limited
by
key
challenges,
including
low
photosensitizer
(PS)
delivery
efficiency,
tumor
microenvironment
hypoxia,
and
the
restricted
diffusion
of
reactive
oxygen
species
(ROS).
This
review
systematically
discusses
innovative
strategies
employed
nanocarrier
systems
overcome
these
bottlenecks
PDT.
The
first
section
focuses
on
challenges
PDT
treatment:
although
induces
localized
cell
death
through
ROS
generation
mediated
PSs,
efficacy
hindered
barriers
hydrophobic
PSs
lung,
insufficient
due
PS
self-quenching.
second
presents
nanotechnology-driven
solutions:
1)
using
nanocarriers
equipped
with
catalase
or
hemoglobin
perfluorocarbon
alleviate
hypoxia
enhance
production;
2)
modifying
surface
targeting
ligands
improve
accumulation
tissues
reduce
self-quenching
effects;
3)
combining
PS-loaded
immune
checkpoint
inhibitors
chemotherapy
agents
synergistically
anti-tumor
suppress
metastasis.
Future
research
should
focus
further
optimizing
biocompatibility,
translation
potential,
multimodal
synergistic
mechanisms
nanocarriers,
promote
widespread
precise
Язык: Английский
Thieno[3,2-b]thiophene based-bridged BODIPY dimer: synthesis, e-chem, one- and two-photon photophysical properties
Zhiyong Chai,
Tingting Gu,
Annaëlle Beau
и другие.
Dalton Transactions,
Год журнала:
2024,
Номер
54(2), С. 674 - 682
Опубликована: Ноя. 12, 2024
Four
BODIPY
dyes
(6a-6d)
with
electron-donating
or
electron-withdrawing
groups
at
the
meso-position
were
synthesized
by
Sonogashira
coupling
reaction
of
2,5-diethynylthieno[3,2-b]thiophene
mono-iodo-BODIPY
moieties.
All
compounds
fully
characterized
1H
NMR
and
MALDI-TOF
MS.
Their
photophysical
electrochemical
properties
studied
UV-visible
absorption
spectroscopy,
steady-state
time-resolved
fluorescence
two-photon
excitation
spectroscopy
cyclic
voltammetry.
These
conjugated
exhibit
interesting
such
as
a
high
molar
extinction
coefficient,
large
Stokes
shift
cross
section
σ2.
Язык: Английский