Transition metal complexes: next-generation photosensitizers for combating Gram-positive bacteria DOI
Ling‐Min Pei,

Xiaolin Yu,

Xiaoyu Shan

и другие.

Future Medicinal Chemistry, Год журнала: 2025, Номер unknown, С. 1 - 18

Опубликована: Янв. 29, 2025

The rise of antibiotic-resistant Gram-positive bacterial infections poses a significant threat to public health, necessitating the exploration alternative therapeutic strategies. A photosensitizer (PS) can convert energy from absorbed photon into reactive oxygen species (ROS) for damaging bacteria. This photoinactivation action bypassing conventional antibiotic mechanism is less prone resistance development, making antibacterial photodynamic therapy (aPDT) highly efficient in combating Photodynamic transition metal complexes leveraging unique properties metals enhance aPDT activity are next-generation PS. review provides an overview metal-based PS Based on structures, these metal-PS could be mainly classified as metal-tetrapyrrole derivatives, ruthenium complexes, iridium and zinc complexes. based other such silver, cobalt, rhenium also presented. Finally, we summarize advantages shortcomings metal- PS, conclude some critical aspects impacting their performances give perspective future development.

Язык: Английский

Transition metal complexes: next-generation photosensitizers for combating Gram-positive bacteria DOI
Ling‐Min Pei,

Xiaolin Yu,

Xiaoyu Shan

и другие.

Future Medicinal Chemistry, Год журнала: 2025, Номер unknown, С. 1 - 18

Опубликована: Янв. 29, 2025

The rise of antibiotic-resistant Gram-positive bacterial infections poses a significant threat to public health, necessitating the exploration alternative therapeutic strategies. A photosensitizer (PS) can convert energy from absorbed photon into reactive oxygen species (ROS) for damaging bacteria. This photoinactivation action bypassing conventional antibiotic mechanism is less prone resistance development, making antibacterial photodynamic therapy (aPDT) highly efficient in combating Photodynamic transition metal complexes leveraging unique properties metals enhance aPDT activity are next-generation PS. review provides an overview metal-based PS Based on structures, these metal-PS could be mainly classified as metal-tetrapyrrole derivatives, ruthenium complexes, iridium and zinc complexes. based other such silver, cobalt, rhenium also presented. Finally, we summarize advantages shortcomings metal- PS, conclude some critical aspects impacting their performances give perspective future development.

Язык: Английский

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