Evaluation of the association of chronic inflammation and cancer: Insights and implications

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 164, С. 115015 - 115015

Опубликована: Июнь 15, 2023

Among the most extensively researched processes in development and treatment of cancer is inflammatory condition. Although acute inflammation essential for wound healing reconstruction tissues that have been damaged, chronic may contribute to onset growth a number diseases, including cancer. By disrupting signaling cells, which result induction, invasion, development, variety molecules are linked The microenvironment surrounding tumor greatly influenced by cells their subsequent secretions, also significantly tumor's growth, survivability, potential migration. These variables mentioned several publications as prospective diagnostic tools anticipating Targeting with various therapies can reduce response potentially limit or block proliferation cells. scientific medical literature from past three decades has studied determine how chemicals cell pathways related invasion metastasis related. current narrative review updates relevant while highlighting specifics possible therapeutic possibilities.

Язык: Английский

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Aging, oxidative stress and degenerative diseases: mechanisms, complications and emerging therapeutic strategies

Biogerontology, Год журнала: 2023, Номер 24(5), С. 609 - 662

Опубликована: Июль 30, 2023

Язык: Английский

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Baicalein as Promising Anticancer Agent: A Comprehensive Analysis on Molecular Mechanisms and Therapeutic Perspectives

Cancers, Год журнала: 2023, Номер 15(7), С. 2128 - 2128

Опубликована: Апрель 3, 2023

Despite significant therapeutic advancements for cancer, an atrocious global burden (for example, health and economic) radio- chemo-resistance limit their effectiveness result in unfavorable consequences. Natural compounds are generally considered safer than synthetic drugs, use cancer treatment alone, or combination with conventional therapies, is increasingly becoming accepted. Interesting outcomes from pre-clinical trials using Baicalein medicines have been reported, some of them also undergone clinical later stages. As a result, we investigated the prospects Baicalein, naturally occurring substance extracted stems Scutellaria baicalensis Georgi Oroxylum indicum Kurz, which targets wide range molecular changes that involved development. In other words, this review primarily driven by findings studies therapy several cell populations based on promising research. The modifications numerous signal transduction mechanisms transcriptional agents highlighted as major players Baicalein’s anti-malignant properties at micro level. These include AKT serine/threonine protein kinase B (AKT) well PI3K/Akt/mTOR, matrix metalloproteinases-2 & 9 (MMP-2 9), Wnt/-catenin, Poly(ADP-ribose) polymerase (PARP), Mitogen-activated (MAPK), NF-κB, Caspase-3/8/9, Smad4, Notch 1/Hes, Signal transducer activator transcription 3 (STAT3), Nuclear factor erythroid 2-related 2 (Nrf2)/Kelch-like ECH-associated protein-1 (Keap 1), Adenosine monophosphate-activated (AMPK), Src/Id1, ROS signaling, miR 183/ezrin, Sonic hedgehog (Shh) signaling cascades. promise anti-inflammatory to anti-apoptotic/anti-angiogenic/anti-metastatic medicinal element treating various malignancies its capability inhibit malignant stem cells, evidence synergistic effects, design nanomedicine-based drugs altogether supported data presented study.

Язык: Английский

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The role of PI3K/Akt signaling pathway in chronic kidney disease

International Urology and Nephrology, Год журнала: 2024, Номер 56(8), С. 2623 - 2633

Опубликована: Март 18, 2024

Язык: Английский

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FDX1 downregulation activates mitophagy and the PI3K/AKT signaling pathway to promote hepatocellular carcinoma progression by inducing ROS production

Redox Biology, Год журнала: 2024, Номер 75, С. 103302 - 103302

Опубликована: Авг. 6, 2024

Mitochondrial dysfunction and metabolic reprogramming can lead to the development progression of hepatocellular carcinoma (HCC). Ferredoxin 1 (FDX1) is a small mitochondrial protein recent studies have shown that FDX1 plays an important role in tumor cuproptosis, but its HCC still elusive. In this study, we aim investigate expression novel functions HCC.

Язык: Английский

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ROS/mtROS promotes TNTs formation via the PI3K/AKT/mTOR pathway to protect against mitochondrial damages in glial cells induced by engineered nanomaterials

Particle and Fibre Toxicology, Год журнала: 2024, Номер 21(1)

Опубликована: Янв. 15, 2024

Abstract Background As the demand and application of engineered nanomaterials have increased, their potential toxicity to central nervous system has drawn increasing attention. Tunneling nanotubes (TNTs) are novel cell–cell communication that plays a crucial role in pathology physiology. However, relationship between TNTs neurotoxicity remains unclear. Here, three types commonly used nanomaterials, namely cobalt nanoparticles (CoNPs), titanium dioxide (TiO 2 NPs), multi-walled carbon (MWCNTs), were selected address this limitation. Results After complete characterization induction formation with all was observed using high-content screening confocal microscopy both primary astrocytes U251 cells. It further revealed TNT protected against nanomaterial-induced due cell apoptosis disrupted ATP production. We then determined mechanism underlying protective TNTs. Since oxidative stress is common nanotoxicity, we first significant increase total mitochondrial reactive oxygen species (namely ROS, mtROS), causing damage. Moreover, pretreatment cells either ROS scavenger N-acetylcysteine or mtROS mitoquinone attenuated generation, suggesting nanomaterials-induced formation. Furthermore, vigorous downstream pathway PI3K/AKT/mTOR pathway, found be actively involved nanomaterials-promoted development, which abolished by LY294002, Perifosine Rapamycin, inhibitors PI3K, AKT, mTOR, respectively. Finally, western blot analysis demonstrated scavengers suppressed abrogated Conclusion Despite biophysical properties, various promote transfer, preventing disrupting production induced nanomaterials. ROS/mtROS activation mechanisms regulate transfer. Our study reveals share same molecular intercellular proposed adverse outcome contributes better understanding protection neurotoxicity. Graphical abstract

Язык: Английский

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Oxidative Stress and Cardiovascular Complications in Type 2 Diabetes: From Pathophysiology to Lifestyle Modifications

Antioxidants, Год журнала: 2025, Номер 14(1), С. 72 - 72

Опубликована: Янв. 9, 2025

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder that significantly increases the risk of cardiovascular disease, which leading cause morbidity and mortality among diabetic patients. A central pathophysiological mechanism linking T2DM to complications oxidative stress, defined as an imbalance between reactive oxygen species (ROS) production body’s antioxidant defenses. Hyperglycemia in promotes stress through various pathways, including formation advanced glycation end products, activation protein kinase C, mitochondrial dysfunction, polyol pathway. These processes enhance ROS generation, endothelial vascular inflammation, exacerbation damage. Additionally, disrupts nitric oxide signaling, impairing vasodilation promoting vasoconstriction, contributes complications. This review explores molecular mechanisms by pathogenesis disease T2DM. It also examines potential lifestyle modifications, such dietary changes physical activity, reducing mitigating risks this high-risk population. Understanding these critical for developing targeted therapeutic strategies improve outcomes

Язык: Английский

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Noncoding RNAs in sepsis-associated acute liver injury: Roles, mechanisms, and therapeutic applications

Pharmacological Research, Год журнала: 2025, Номер 212, С. 107596 - 107596

Опубликована: Янв. 10, 2025

Sepsis is a life-threatening syndrome characterized by organ dysfunction caused dysregulated host response to infection. Sepsis-associated acute liver injury (SA-ALI) frequent and serious complication of sepsis that considerably impacts both short-term long-term survival outcomes. In intensive care units (ICUs), the mortality rate patients with SA-ALI remains high, mostly due absence effective early diagnostic markers suitable therapeutic strategies. Recent studies have demonstrated importance non-coding RNAs (ncRNAs) in development progression SA-ALI. This review focuses on critical roles ncRNAs, including microRNAs (miRNAs), long (lncRNAs), circular (circRNAs), regulating "cytokine storms", oxidative stress, mitochondrial dysfunction, programmed cell death SA-ALI, summarizes current state limitations existing lncRNAs circRNAs By integrating advancements high-throughput sequencing technologies, this provides novel insights into dual potential ncRNAs as biomarkers targets, offers new ideas for diagnosis treatment research highlights challenges clinical translation.

Язык: Английский

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Molecular mechanisms behind ROS regulation in cancer: A balancing act between augmented tumorigenesis and cell apoptosis

Archives of Toxicology, Год журнала: 2022, Номер 97(1), С. 103 - 120

Опубликована: Ноя. 28, 2022

Язык: Английский

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Impacts of Oxidative Stress and PI3K/AKT/mTOR on Metabolism and the Future Direction of Investigating Fucoidan-Modulated Metabolism

Antioxidants, Год журнала: 2022, Номер 11(5), С. 911 - 911

Опубликована: Май 6, 2022

The critical factors for regulating cancer metabolism are oxidative stress and phosphoinositide-3-kinase/AKT serine-threonine kinase/mechanistic target of the rapamycin kinase (PI3K/AKT/mTOR). However, metabolic impacts PI3K/AKT/mTOR on individual mechanisms such as glycolysis (Warburg effect), pentose phosphate pathway (PPP), fatty acid synthesis, tricarboxylic cycle (TCA) cycle, glutaminolysis, phosphorylation (OXPHOS) complicated. Therefore, this review summarizes interacting functions metabolism. Moreover, natural products providing modulating effects have anticancer potential. Using example brown algae-derived fucoidan, roles were summarized, although their potential within diverse metabolisms rarely investigated. We propose a application that fucoidan may regulate signaling to modulate associated regulations. This sheds light understanding future direction metabolism-based therapy fucoidan.

Язык: Английский

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