Anti‐obesity peptides from food: Production, evaluation, sources, and commercialization
Comprehensive Reviews in Food Science and Food Safety,
Год журнала:
2025,
Номер
24(2)
Опубликована: Март 1, 2025
The
global
obesity
epidemic
has
heightened
interest
in
natural
solutions,
with
anti-obesity
peptides
emerging
as
promising
candidates.
Derived
from
food
sources
such
plants,
algae,
marine
organisms,
and
products
like
milk
eggs,
these
combat
through
various
mechanisms
but
face
challenges
production
scalability.
aim
of
this
review
is
to
explore
their
sources,
mechanisms,
measurement,
synthesis
methods,
including
innovative
approaches
de
novo
synthesis,
proteomics,
bioinformatics.
Its
unique
contribution
lies
critically
analyzing
the
current
state
research
while
highlighting
novel
techniques
practical
relevance
addressing
commercialization
challenges,
offering
valuable
insights
for
advancing
peptide
development.
Diverse
methods
assessing
properties
are
discussed,
encompassing
both
vitro
vivo
experimental
approaches,
well
alternatives.
also
explores
integration
cutting-edge
technologies
potential
revolutionize
scalability
cost-effectiveness.
Key
findings
assert
that
despite
great
fight
against
advances
identification
analysis,
scalability,
regulatory
hurdles,
bioavailability
issues,
high
costs,
consumer
appeal
persist.
Future
should
use
bioinformatics
tools
advanced
screening
identify
design
enhanced
efficacy
bioavailability,
efficient
cost-effective
extraction
purification
sustainable
practices
utilizing
byproducts
industry,
containing
isolated
versus
whole
materials
clinical
settings.
Язык: Английский
High Fat Low Carbohydrate Diet Is Linked to CNS Autoimmunity Protection
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 27, 2025
Abstract
Multiple
sclerosis
(MS)
is
an
inflammatory
and
neurodegenerative
disease
of
the
central
nervous
system
(CNS)
believed
to
be
driven
by
autoimmune
mechanisms.
Genetic
environmental
factors
are
implicated
in
MS
development,
among
latter,
diets
nutrients
emerging
as
potential
critical
contributors.
However,
a
comprehensive
understanding
their
impacts
underlying
mechanisms
involved
lacking.
Harnessing
state‐of‐the‐art
nutritional
geometry
analytical
methods,
it
first
revealed
that
globally,
increased
carbohydrate
supply
associated
with
burden,
while
fat
has
opposite
effect.
Furthermore,
mouse
model,
experimental
encephalomyelitis
(EAE),
found
isocaloric
diet
high
aggravated
EAE,
enriched
(HF)
fully
protective.
This
reflected
reduced
neuroinflammation
skewing
toward
anti‐inflammatory
phenotypes.
The
protective
effects
from
HF
multifaceted.
Metabolically,
lipid
storage
immune
cells,
correlating
IL‐10
production.
Transcriptionally
epigenetically,
feeding
preprogrammed
naïve
T
cells
less
activated
but
more
tolerogenic
phenotype.
It
showcased
manipulating
potentially
efficient
cost‐effective
approach
prevent
and/or
ameliorate
EAE.
exhibits
translational
potentials
for
prevention/intervention
possibly
other
diseases.
Язык: Английский