BioEssays, Год журнала: 2024, Номер 46(12)
Опубликована: Окт. 14, 2024
Abstract Pluripotent stem cell lines derived from preimplantation mouse embryos have opened opportunities for the study of early mammalian development and generation genetically uncompromised material differentiation into specific types. Murine embryonic cells are highly versatile can be engineered introduced host embryos, transferred to recipient females, gestated investigate gene function at multiple levels as well developmental mechanisms, including lineage segregation competition. In this review, we summarize biomedical motivation driving incremental modification culture regimes analyses that advanced research its current state. Ongoing investigation divergent mechanisms processes adopted by other species, such agriculturally beneficial mammals birds, will continue enrich knowledge inform strategies future in vitro models.
Язык: Английский