Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Дек. 1, 2023
Immunotherapy
is
a
therapeutic
approach
that
employs
immunological
principles
and
techniques
to
enhance
amplify
the
body’s
immune
response,
thereby
eradicating
tumor
cells.
has
demonstrated
effective
antitumor
effects
on
variety
of
malignant
tumors.
However,
when
applied
humans,
many
immunotherapy
drugs
fail
target
lesions
with
precision,
leading
an
array
adverse
immune-related
reactions
profoundly
limit
clinical
application
immunotherapy.
Nanodrug
delivery
systems
enable
precise
immunotherapeutic
targeted
tissues
or
specific
cells,
enhancing
effect
while
reducing
number
reactions.
A
nanodrug
system
provides
feasible
strategy
for
activating
response
by
following
mechanisms:
1)
increased
targeting
uptake
vaccines
DCs,
which
enhances
efficacy
response;
2)
cell
immunogenicity;
3)
regulation
TAMs
other
cells
by,
example,
regulating
polarization
interfering
TAN
formation,
ECM
remodeling
CAFs;
4)
interference
escape
signaling
pathways,
namely,
PD-1/PD-L1,
FGL1/LAG-3
IDO
pathways.
This
paper
reviews
progress
research
respect
based
immunomodulation
over
last
few
years,
discussing
promising
future
these
under
this
domain.
Heliyon,
Год журнала:
2024,
Номер
10(3), С. e25477 - e25477
Опубликована: Фев. 1, 2024
The
health
of
the
reproductive
system
is
intricately
linked
to
female
fertility
and
quality
life.
There
has
been
a
growing
prevalence
disorders
among
women,
particularly
in
younger
age
groups,
resulting
significant
adverse
effects
on
their
health.
Consequently,
there
an
urgent
need
for
effective
treatment
modalities.
Nanotechnology,
as
advanced
discipline,
provides
innovative
avenues
managing
treating
diseases
by
enabling
precise
manipulation
regulation
biological
molecules
cells.
By
utilizing
nanodelivery
systems,
drugs
can
be
administered
with
pinpoint
accuracy,
leading
reduced
side
improved
therapeutic
efficacy.
Moreover,
nanomaterial
imaging
techniques
enhance
diagnostic
precision
sensitivity,
aiding
assessment
disease
severity
progression.
Furthermore,
implementation
nanobiosensors
facilitates
early
detection
prevention
ailments.
This
comprehensive
review
aims
summarize
recent
applications
nanotechnology
diseases.
latest
advancements
drug
delivery,
diagnosis,
approaches
will
discussed,
emphasis
potential
improve
outcomes
overall
Biosensors,
Год журнала:
2024,
Номер
14(4), С. 197 - 197
Опубликована: Апрель 17, 2024
Controlling
the
progression
of
contagious
diseases
is
crucial
for
public
health
management,
emphasizing
importance
early
viral
infection
diagnosis.
In
response,
lateral
flow
assays
(LFAs)
have
been
successfully
utilized
in
point-of-care
(POC)
testing,
emerging
as
a
viable
alternative
to
more
traditional
diagnostic
methods.
Recent
advancements
virus
detection
primarily
leveraged
methods
such
reverse
transcription–polymerase
chain
reaction
(RT-PCR),
transcription–loop-mediated
isothermal
amplification
(RT-LAMP),
and
enzyme-linked
immunosorbent
assay
(ELISA).
Despite
their
proven
effectiveness,
these
conventional
techniques
are
often
expensive,
require
specialized
expertise,
consume
significant
amount
time.
contrast,
LFAs
utilize
nanomaterial-based
optical
sensing
technologies,
including
colorimetric,
fluorescence,
surface-enhanced
Raman
scattering
(SERS),
offering
quick,
straightforward
analyses
with
minimal
training
infrastructure
requirements
detecting
proteins
biological
samples.
This
review
describes
composition
mechanism
recent
protein
detection,
categorizing
them
into
fluorescent,
SERS-based
techniques.
progress,
developing
simple,
stable,
highly
sensitive,
selective
LFA
system
remains
formidable
challenge.
Nevertheless,
an
advanced
promises
not
only
enhance
clinical
diagnostics
but
also
extend
its
utility
environmental
monitoring
beyond,
demonstrating
potential
revolutionize
both
healthcare
safety.
Advanced Optical Materials,
Год журнала:
2025,
Номер
13(4)
Опубликована: Янв. 17, 2025
Abstract
A
new
method
is
presented
for
the
in
vitro
detection
of
glucose
using
oxidase
(GOx)
covalently
linked
to
persistent
luminescent
nanoparticles
(PLNPs).
This
ensures
both
sensitive
and
specific
by
exploiting
enhanced
luminescence
PLNPs
presence
H
2
O
,
generated
an
enzymatic
reaction.
To
this
end,
three
different
composed
ZnGa
4
:Cr
3+
(ZGO)
are
prepared
hydrothermal
synthesis
at
120
°C
6
h
(ZGO1),
12
(ZGO2),
24
(ZGO3),
followed
a
calcination
500
°C,
resulting
with
average
hydrodynamic
diameter
100
nm
±
5
after
grinding
centrifugation.
These
efficiently
functionalized
GOx,
via
PEG
linker.
Following
production
reaction
between
GOx
bound
ZGO
surface
present
100‐fold
diluted
serum,
significant
increase
signal
observed.
phenomenon
most
pronounced
ZGO2,
which
limit
0.01
µ
m
range
from
0.05
1
obtained.
results
demonstrate
innovative
potential
technique
monitoring,
opening
up
avenues
real‐time
monitoring
effective
management
diabetes.
Foods,
Год журнала:
2025,
Номер
14(7), С. 1115 - 1115
Опубликована: Март 24, 2025
Food
safety
is
directly
related
to
human
health
and
has
attracted
intense
attention
all
over
the
world.
Surface-enhanced
Raman
scattering
(SERS),
as
a
rapid
selective
technique,
been
widely
applied
in
monitoring
food
safety.
SERS
substrates,
an
essential
factor
for
sensing
design,
greatly
influence
analytical
performance.
Currently,
nanostructure-based
substrates
have
garnered
significant
interest
due
their
excellent
merits
improving
sensitivity,
specificity,
stability,
holding
great
potential
accurate
of
contaminants
complex
matrices.
This
review
summarizes
fundamentals
spectroscopy
used
nanostructures
designing
platform,
including
precious
metal
nanoparticles,
metal-organic
frameworks,
polymers,
semiconductors.
Moreover,
it
introduces
mechanisms
applications
enhancing
signals
hazardous
substances,
such
foodborne
bacteria,
pesticide
veterinary
drug
residues,
additives,
illegal
adulterants,
packaging
material
contamination.
Finally,
with
continuous
progress
nanostructure
technology
improvement
technology,
its
application
prospect
testing
will
be
broader.
