Advances in tumor immunomodulation based on nanodrug delivery systems DOI Creative Commons
Bo Wang, Yue Zhang,

Xunzhe Yin

и другие.

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Дек. 1, 2023

Immunotherapy is a therapeutic approach that employs immunological principles and techniques to enhance amplify the body’s immune response, thereby eradicating tumor cells. has demonstrated effective antitumor effects on variety of malignant tumors. However, when applied humans, many immunotherapy drugs fail target lesions with precision, leading an array adverse immune-related reactions profoundly limit clinical application immunotherapy. Nanodrug delivery systems enable precise immunotherapeutic targeted tissues or specific cells, enhancing effect while reducing number reactions. A nanodrug system provides feasible strategy for activating response by following mechanisms: 1) increased targeting uptake vaccines DCs, which enhances efficacy response; 2) cell immunogenicity; 3) regulation TAMs other cells by, example, regulating polarization interfering TAN formation, ECM remodeling CAFs; 4) interference escape signaling pathways, namely, PD-1/PD-L1, FGL1/LAG-3 IDO pathways. This paper reviews progress research respect based immunomodulation over last few years, discussing promising future these under this domain.

Язык: Английский

The utilization of nanotechnology in the female reproductive system and related disorders DOI Creative Commons
Xin Luo,

Keran Jia,

Jinshan Xing

и другие.

Heliyon, Год журнала: 2024, Номер 10(3), С. e25477 - e25477

Опубликована: Фев. 1, 2024

The health of the reproductive system is intricately linked to female fertility and quality life. There has been a growing prevalence disorders among women, particularly in younger age groups, resulting significant adverse effects on their health. Consequently, there an urgent need for effective treatment modalities. Nanotechnology, as advanced discipline, provides innovative avenues managing treating diseases by enabling precise manipulation regulation biological molecules cells. By utilizing nanodelivery systems, drugs can be administered with pinpoint accuracy, leading reduced side improved therapeutic efficacy. Moreover, nanomaterial imaging techniques enhance diagnostic precision sensitivity, aiding assessment disease severity progression. Furthermore, implementation nanobiosensors facilitates early detection prevention ailments. This comprehensive review aims summarize recent applications nanotechnology diseases. latest advancements drug delivery, diagnosis, approaches will discussed, emphasis potential improve outcomes overall

Язык: Английский

Процитировано

12

Extracellular vesicles associated microRNAs: Their biology and clinical significance as biomarkers in gastrointestinal cancers DOI
Yuan Li,

Silei Sui,

Ajay Goel

и другие.

Seminars in Cancer Biology, Год журнала: 2024, Номер 99, С. 5 - 23

Опубликована: Фев. 1, 2024

Язык: Английский

Процитировано

12

Highly Sensitive Detection of Glucose in the Presence of Serum Based on Signal Amplification of Persistent Luminescence Nanoparticles Functionalized by Glucose Oxidase DOI Creative Commons
Zied Ferjaoui, Celina Matuszewska, Jianhua Liu

и другие.

Advanced Optical Materials, Год журнала: 2025, Номер 13(4)

Опубликована: Янв. 17, 2025

Abstract A new method is presented for the in vitro detection of glucose using oxidase (GOx) covalently linked to persistent luminescent nanoparticles (PLNPs). This ensures both sensitive and specific by exploiting enhanced luminescence PLNPs presence H 2 O , generated an enzymatic reaction. To this end, three different composed ZnGa 4 :Cr 3+ (ZGO) are prepared hydrothermal synthesis at 120 °C 6 h (ZGO1), 12 (ZGO2), 24 (ZGO3), followed a calcination 500 °C, resulting with average hydrodynamic diameter 100 nm ± 5 after grinding centrifugation. These efficiently functionalized GOx, via PEG linker. Following production reaction between GOx bound ZGO surface present 100‐fold diluted serum, significant increase signal observed. phenomenon most pronounced ZGO2, which limit 0.01 µ m range from 0.05 1 obtained. results demonstrate innovative potential technique monitoring, opening up avenues real‐time monitoring effective management diabetes.

Язык: Английский

Процитировано

1

Applications of biochar in sensors: Recent advancements and future trends DOI

Himani,

Amrita Amrita,

Tripti Agarwal

и другие.

Materials Today Chemistry, Год журнала: 2025, Номер 45, С. 102646 - 102646

Опубликована: Март 19, 2025

Язык: Английский

Процитировано

1

Recent Advances in Food Safety: Nanostructure-Sensitized Surface-Enhanced Raman Sensing DOI Creative Commons
Zeyan Liu, Renchun Yang, Haili Chen

и другие.

Foods, Год журнала: 2025, Номер 14(7), С. 1115 - 1115

Опубликована: Март 24, 2025

Food safety is directly related to human health and has attracted intense attention all over the world. Surface-enhanced Raman scattering (SERS), as a rapid selective technique, been widely applied in monitoring food safety. SERS substrates, an essential factor for sensing design, greatly influence analytical performance. Currently, nanostructure-based substrates have garnered significant interest due their excellent merits improving sensitivity, specificity, stability, holding great potential accurate of contaminants complex matrices. This review summarizes fundamentals spectroscopy used nanostructures designing platform, including precious metal nanoparticles, metal-organic frameworks, polymers, semiconductors. Moreover, it introduces mechanisms applications enhancing signals hazardous substances, such foodborne bacteria, pesticide veterinary drug residues, additives, illegal adulterants, packaging material contamination. Finally, with continuous progress nanostructure technology improvement technology, its application prospect testing will be broader.

Язык: Английский

Процитировано

1

Recent Advances in Lateral Flow Assays for Viral Protein Detection with Nanomaterial-Based Optical Sensors DOI Creative Commons
Min Jung Kim,

Izzati Haizan,

Min Ju Ahn

и другие.

Biosensors, Год журнала: 2024, Номер 14(4), С. 197 - 197

Опубликована: Апрель 17, 2024

Controlling the progression of contagious diseases is crucial for public health management, emphasizing importance early viral infection diagnosis. In response, lateral flow assays (LFAs) have been successfully utilized in point-of-care (POC) testing, emerging as a viable alternative to more traditional diagnostic methods. Recent advancements virus detection primarily leveraged methods such reverse transcription–polymerase chain reaction (RT-PCR), transcription–loop-mediated isothermal amplification (RT-LAMP), and enzyme-linked immunosorbent assay (ELISA). Despite their proven effectiveness, these conventional techniques are often expensive, require specialized expertise, consume significant amount time. contrast, LFAs utilize nanomaterial-based optical sensing technologies, including colorimetric, fluorescence, surface-enhanced Raman scattering (SERS), offering quick, straightforward analyses with minimal training infrastructure requirements detecting proteins biological samples. This review describes composition mechanism recent protein detection, categorizing them into fluorescent, SERS-based techniques. progress, developing simple, stable, highly sensitive, selective LFA system remains formidable challenge. Nevertheless, an advanced promises not only enhance clinical diagnostics but also extend its utility environmental monitoring beyond, demonstrating potential revolutionize both healthcare safety.

Язык: Английский

Процитировано

9

MOFs/COFs-based hybrids for agricultural sensors: Current state of art and beyond DOI
Xin Liu,

Peidi Fan,

Xiaoyu Su

и другие.

TrAC Trends in Analytical Chemistry, Год журнала: 2024, Номер 172, С. 117603 - 117603

Опубликована: Фев. 20, 2024

Язык: Английский

Процитировано

8

Portable analysis of tract mercury ions by a hydrogel-based ratiometric fluorescence sensor using C3N4-CdTe0.16S0.84 QDs nanocomposites DOI
Xinrong Guo, Junhui Xiao, Yanhua Zhang

и другие.

Sensors and Actuators B Chemical, Год журнала: 2024, Номер 413, С. 135846 - 135846

Опубликована: Апрель 21, 2024

Язык: Английский

Процитировано

8

Development of sustainable fluorescence approach with red emissive carbon dots derived from Grewia asiatica fruit for the detection of quinalphos DOI

Foziya Yusuf Vadia,

Sanjay Jha, Vaibhavkumar N. Mehta

и другие.

Journal of Photochemistry and Photobiology A Chemistry, Год журнала: 2024, Номер 458, С. 115948 - 115948

Опубликована: Авг. 9, 2024

Язык: Английский

Процитировано

8

Molybdenum disulfide nanosheet induced reactive oxygen species for high-efficiency luminol chemiluminescence DOI

Chuanlin Huang,

Wenjuan Zhou, Weijiang Guan

и другие.

Analytica Chimica Acta, Год журнала: 2024, Номер 1295, С. 342324 - 342324

Опубликована: Фев. 3, 2024

Язык: Английский

Процитировано

7