A switch-off fluorescent probe for the ultrafast and sensitive determination of vanillin in different food matrices and beyond

Journal of Food Composition and Analysis, Год журнала: 2025, Номер unknown, С. 107586 - 107586

Опубликована: Апрель 1, 2025

Язык: Английский

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Rapid Microwave‐Assisted Synthesis of Nitrogen‐Doped Carbon Quantum Dots as Fluorescent Nanoprobe for Sensitive Estimation of Tizanidine in Human Urine and Dosage Forms: Application to Content Uniformity Testing

Luminescence, Год журнала: 2025, Номер 40(4)

Опубликована: Апрель 1, 2025

This study introduces a novel sensitive and environment-friendly spectrofluorimetric method for determination of an important muscle relaxant drug, tizanidine, with no need using organic solvents or any pre-derivatization steps. strategy depends on tizanidine quenching effect the native fluorescence newly synthesized nitrogen-doped carbon quantum dots (N-CQDs) from Tetraclinis articulata extract, first time, microwave-assisted synthetic in only 4 min. Full characterization N-CQDs was performed by different microscopic spectroscopic techniques. The showed good emission at 380 nm when excited 312 nm. is one analysis spectrofluorimetrically as nanosensors. developed approach demonstrated linearity within range 0.1-1.0 μg/mL correlation coefficient 0.9997 detection limit 0.024 μg/mL. successfully applied estimation its tablets human urine samples high % recoveries (98.04-101.67) low %RSD (< 1.5) values. Furthermore, content uniformity testing accordance USP guidelines. method's eco-friendliness evaluated AGREE ComplexGAPI metrics. Validation according to ICHQ2 (R2)

Язык: Английский

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Ultrasensitive turn-off fluorescent sensor for estimation of the new influenza antiviral prodrug baloxavir marboxil in its pharmaceutical formulation

Royal Society Open Science, Год журнала: 2025, Номер 12(1)

Опубликована: Янв. 1, 2025

Carbon quantum dots (CQDs) are a recently developed class of fluorescent nanoparticles made from carbon. Co-doping with heteroatoms such as nitrogen and sulfur improved the properties generated high yield. In proposed study, we utilized simple, cost-effective, single-stage hydrothermal approach to produce extreme photoluminescence co-doped, sulfur, CQDs (N,S-CODs). Thiosemicarbazide was used source, while citric acid carbon source probes. The prepared N,S-CQDs were subjected extensive characterization. yielded strong fluorescence emission at λ em 430.0 nm after excitation ex 360.0 nm, relatively yield 41.3% utilizing quinine sulfate reference compound. These applied nanosensors for ultrasensitive spectrofluorimetric determination baloxavir marboxil (BXM) directly without pre-derivatization first time. BXM effectively quenches native N,S-CQDs. Considering optimal conditions, intensity reduction exhibited ‘turn-off’ response concentrations 10.0–100.0 ng ml −1 , detection limits 1.88 quantitation 5.69 respectively. method determined successfully in its tablet dosage form further expanded confirm content uniformity units agreement USP guidelines.

Язык: Английский

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Ultrafast green synthesis of silver nanoparticles as fluorescent nanosensors for determination of isoniazid and nitrofurantoin in biological fluids and pharmaceuticals

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Май 3, 2025

Abstract The current study presents a green, straightforward, and ultrafast microwave-assisted method for the synthesis of Ag-NPs in only 40 s, using Paeonia officinalis root extract as reducing agent, first time. Characterization produced was carried out different spectroscopic microscopic methods. They exhibited strong emission peak at 318 nm following excitation 227 nm. developed were utilized green fluorescent nanosensor determination isoniazid (ISN) nitrofurantoin sodium (NIF). native fluorescence observed to be quantitatively quenched by studied drugs. Validation linear relationship ISN NIF range 20.0-100.0 µM 10.0–60.0 with detection limits 1.12 0.98 µM, respectively. Due high selectivity sensitivity, suggested also applied estimation biological fluid samples pharmaceutical formulations acceptable % RSD recoveries. Assessment Ag-NPs’ antimicrobial activity performed, synthesized showed noteworthy activities. evaluation method’s eco-friendliness greenness performed AGREE ComplexGAPI metrics. ICHQ2 (R2) guidelines followed validate method.

Язык: Английский

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Carbon Quantum Dots in Spectrofluorimetric Analysis: A Comprehensive Review of Synthesis, Mechanisms and Multifunctional Applications

Talanta, Год журнала: 2025, Номер unknown, С. 128066 - 128066

Опубликована: Апрель 1, 2025

Язык: Английский

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Unlocking the Power of Nanohybrids: A Critical Review on Carbon Nanomaterial-Functionalized Silver Nanoparticles for Advanced Antimicrobial Applications

Colloids and Surfaces B Biointerfaces, Год журнала: 2025, Номер unknown, С. 114678 - 114678

Опубликована: Апрель 1, 2025

Язык: Английский

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A novel ultrasensitive derivatization-free synchronous fluorescence approach for the simultaneous analysis of propofol and nalbuphine in human plasma and dosage forms: Compliance with greenness and blueness metrics

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Год журнала: 2025, Номер 340, С. 126339 - 126339

Опубликована: Май 5, 2025

Язык: Английский

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Jute Mallow Leaves Biomass as a Green Source for the Microwave‐Assisted Synthesis of N,S‐Carbon Quantum Dots: Application to the Sensitive Sensing of the Anticancer Drug Afatinib in Environmental Water Samples

Luminescence, Год журнала: 2025, Номер 40(6)

Опубликована: Май 28, 2025

ABSTRACT This research presents a novel and efficient microwave‐assisted method for synthesizing nitrogen‐ sulfur‐doped carbon quantum dots (N,S‐CQDs) using Corchorus olitorius leaves (Jute mallow) as sustainable green source thiourea nitrogen sulfur source. The achieves remarkable efficiency, enabling the synthesis of N,S‐CQDs in just 50 s. Diverse characterization approaches validated distinctive optical morphological characteristics N,S‐CQDs. yield was determined to be high 22%, indicating their efficiency fluorescent nanoprobes. have switch‐off fluorescence suitable determining anticancer afatinib various environmental water samples. demonstrated outstanding linearity across range 1.0–12.0 μg/mL ( R 2 > 0.999) limit detection low 0.13 μg/mL. analysis numerous samples with percentage recoveries revealed efficacy sensitive platform. A holistic evaluation greenness, practicality, performed diverse metrics, validating its exceptional eco‐friendliness broad application. innovative facilitates development environmentally nanoprobes much relevance ecological monitoring.

Язык: Английский

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Carbon Dot-Based Nanoparticles: A Promising Therapeutic Approach for Glioblastoma

International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 7061 - 7092

Опубликована: Май 1, 2025

Язык: Английский

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