Neurotoxicity Research, Год журнала: 2021, Номер 39(3), С. 787 - 799
Опубликована: Апрель 16, 2021
Язык: Английский
Frontiers in Pharmacology, Год журнала: 2021, Номер 12
Опубликована: Апрель 15, 2021
Alzheimer’s disease (AD) and Parkinson’s (PD) are two typical neurodegenerative diseases that increased with aging. With the emergence of aging population, health problem economic burden caused by also increase. Phosphatidylinositol 3-kinases/protein kinase B (PI3K/AKT) signaling pathway regulates signal transduction biological processes such as cell proliferation, apoptosis metabolism. According to reports, it neurotoxicity mediates survival neurons through different substrates forkhead box protein Os (FoxOs), glycogen synthase kinase-3β (GSK-3β), caspase-9. Accumulating evidences indicate some natural products can play a neuroprotective role activating PI3K/AKT pathway, providing an effective resource for discovery potential therapeutic drugs. This article reviews relationship between AKT AD PD, discusses based on treat in recent years, hoping provide guidance reference this field. Further development Chinese herbal medicine is needed these diseases.
Язык: Английский
Процитировано
326
Molecules, Год журнала: 2021, Номер 26(16), С. 4998 - 4998
Опубликована: Авг. 18, 2021
Curcuma longa is very well-known medicinal plant not only in the Asian hemisphere but also known across globe for its therapeutic and benefits. The active moiety of curcumin has gained importance various treatments disorders such as antibacterial, antiprotozoal, cancer, obesity, diabetics wound healing applications. Several techniques had been exploited reported by researchers increasing potential pharmacological activity. Here, dictum new room development physicochemical, well biological, studies efficacy target specificity. we discussed nanoformulation techniques, which lend support to upgrade characters enhancing bioavailability, solubility, modifying metabolisms, specificity, prolonged circulation, enhanced permeation. Our manuscript tried seek attention researcher framing some solutions existing troubleshoots this bioactive component applications making formulations feasible at an industrial production scale. This focuses on recent inventions well, can further be implemented community level.
Язык: Английский
Процитировано
173
Biomedicines, Год журнала: 2023, Номер 11(9), С. 2488 - 2488
Опубликована: Сен. 7, 2023
Mitochondria play a vital role in maintaining cellular energy homeostasis, regulating apoptosis, and controlling redox signaling. Dysfunction of mitochondria has been implicated the pathogenesis various brain diseases, including neurodegenerative disorders, stroke, psychiatric illnesses. This review paper provides comprehensive overview intricate relationship between disease, focusing on underlying pathological mechanisms exploring potential therapeutic opportunities. The covers key topics such as mitochondrial DNA mutations, impaired oxidative phosphorylation, dynamics, calcium dysregulation, reactive oxygen species generation context disease. Additionally, it discusses emerging strategies targeting dysfunction, protective agents, metabolic modulators, gene therapy approaches. By critically analysing existing literature recent advancements, this aims to enhance our understanding multifaceted disease shed light novel interventions.
Язык: Английский
Процитировано
78
Pharmaceutics, Год журнала: 2020, Номер 12(11), С. 1084 - 1084
Опубликована: Ноя. 11, 2020
Doxorubicin (DOX) is a well-known chemotherapeutic agent extensively applied in the field of cancer therapy. However, similar to other agents such as cisplatin, paclitaxel, docetaxel, etoposide and oxaliplatin, cells are able obtain chemoresistance that limits DOX efficacy. In respect dose-dependent side effect DOX, enhancing its dosage not recommended for effective chemotherapy. Therefore, different strategies have been considered reversing resistance diminishing effects. Phytochemical potential candidates this case due their great pharmacological activities. Curcumin antitumor phytochemical isolated from Curcuma longa with capacity suppressing metastasis proliferation affecting molecular pathways. Experiments demonstrated curcumin inhibiting by downregulating oncogene pathways MMP-2, TGF-β, EMT, PI3K/Akt, NF-κB AP-1. Furthermore, coadministration potentiates apoptosis induction cells. light this, nanoplatforms employed codelivery DOX. This results promoting bioavailability internalization aforementioned active compounds and, consequently, activity. Noteworthy, has reducing adverse effects on normal tissues via inflammation, oxidative stress apoptosis. The current review highlights anticancer mechanism, nanovehicles.
Язык: Английский
Процитировано
106
Antioxidants, Год журнала: 2021, Номер 10(7), С. 1069 - 1069
Опубликована: Июль 2, 2021
The increase in human life expectancy has become a challenge to reduce the deleterious consequences of aging. Nowadays, an increasing number population suffer from age-associated neurodegenerative diseases including Parkinson's disease (PD) and Alzheimer's (AD). These disorders present different signs neurodegeneration such as mitochondrial dysfunction, inflammation, oxidative stress. Accumulative evidence suggests that transcriptional factor nuclear (erythroid-derived 2)-like 2 (Nrf2) plays vital defensive role orchestrating antioxidant response brain. Nrf2 activation promotes expression several enzymes exert cytoprotective effects against damage impairment. In this context, studies have proposed pathogenesis PD AD. Thus, we consider it important summarize ongoing literature related pathway context these diseases. Therefore, review, discuss mechanisms involved activity its connection with mitochondria, energy supply, Furthermore, will lead our discussion identify participation impairment Finally, therapeutic could on cognitive impairment, neurodegeneration, failure
Язык: Английский
Процитировано
100
Journal of environmental chemical engineering, Год журнала: 2021, Номер 9(4), С. 105520 - 105520
Опубликована: Май 26, 2021
Язык: Английский
Процитировано
96
Medicina, Год журнала: 2020, Номер 56(7), С. 336 - 336
Опубликована: Июль 3, 2020
This review discusses the impact of curcumin—an aromatic phytoextract from turmeric (Curcuma longa) rhizome—as an effective therapeutic agent. Despite all beneficial health properties ensured by curcumin application, its pharmacological efficacy is compromised in vivo due to poor aqueous solubility, high metabolism, and rapid excretion that may result systemic bioavailability. To overcome these problems, novel nanosystems have been proposed enhance bioavailability bioactivity reducing particle size, modification surfaces, encapsulation efficiency with different nanocarriers. The solutions based on nanotechnology can improve perspective for medical patients serious illnesses. In this review, we discuss commonly used curcumin-loaded bio-based nanoparticles should be implemented overcoming innate constraints natural ingredient. Furthermore, associated challenges regarding potential applications combination therapies are discussed as well.
Язык: Английский
Процитировано
90
International Journal of Pharmaceutics, Год журнала: 2020, Номер 585, С. 119476 - 119476
Опубликована: Май 27, 2020
Язык: Английский
Процитировано
89
Phytotherapy Research, Год журнала: 2020, Номер 34(8), С. 1745 - 1760
Опубликована: Март 10, 2020
Abstract Curcumin is a naturally occurring nutraceutical compound with number of therapeutic and biological activities such as antioxidant, anti‐inflammatory, anti‐diabetic, antitumor, cardioprotective. This plant‐derived chemical has demonstrated great potential in targeting various signaling pathways to exert its protective effects. Signal transducers activator transcription (STAT) one the molecular involved variety processes cell proliferation apoptosis. Accumulating data demonstrates that STAT pathway an important target treatment disorders, particularly cancer. capable affecting induction impacts. able enhance level anti‐inflammatory cytokines improve inflammatory disorders colitis by pathway. Furthermore, studies show inhibition JAK/STAT curcumin reduced migration invasion cancer cells. normalizes expression renoprotective, neuroprotective At present review, we provide comprehensive discussion about effect on direct further this field.
Язык: Английский
Процитировано
81
Clinica Chimica Acta, Год журнала: 2020, Номер 513, С. 6 - 12
Опубликована: Дек. 9, 2020
Язык: Английский
Процитировано
76