Biotransformation of phytochemicals: Way forward to gut microbial, nutraceuticals and herbal therapeutics advancements DOI Creative Commons
Birbal Singh, Gorakh Mal, Rinku Sharma

и другие.

Functional Food Science - Online ISSN 2767-3146, Год журнала: 2024, Номер 4(3), С. 96 - 118

Опубликована: Март 25, 2024

Mammalian gastrointestinal tract is inhabited by trillions of symbiotic microbiotas representing viruses, bacteria, archaea and eukaryotes including yeasts, fungi protozoa. Compared to humans, the herbivores harbor a complex metabolically efficient microbes which not only detoxify inadvertently consumed anti-nutritional phytochemicals, but also convert ingested tannin-polyphenols, saponins, phytoestrogens alkaloids into metabolites are more available bioactive than their precursors. Some toxicants eliminate them from body. The resulting display range nutritional therapeutic benefits besides direct impact on enhancing diversity functioning gut microbiome. Metabolically active microbiota generated might be futuristic alternative biotherapeutics develop nutraceuticals plant-based health formulations primarily for ‘metabotype 0’ individuals. Further insights novel microbial species, modes biotransformation phytochemicals botanicals will pave way non-antibiotic interventions avert infections boost human veterinary health. Keywords: Gut microbiome; Phytochemicals; Biotransformation; Biotherapeutics Highlights: dietary prevent host against chronic diseases infections. Little known about metabolism action GI herbal supplements. having anti-inflammatory, anti-oxidative anti-carcinogenic properties therapeutics.

Язык: Английский

Reshaping the Gut Microbiota: Tangliping Decoction and Its Core Blood-Absorbed Component Quercetin Improve Diabetic Cognitive Impairment DOI

Wenlan Zhang,

Chunmei Yi,

Zhijie Song

и другие.

Phytomedicine, Год журнала: 2025, Номер 140, С. 156560 - 156560

Опубликована: Март 5, 2025

Язык: Английский

Процитировано

0
From Clinical to Basic Research: The Neuroprotective Effects and Mechanisms of Caffeine DOI

Lijing Wang,

Linxi Wang

Опубликована: Апрель 1, 2025

Review From Clinical to Basic Research: The Neuroprotective Effects and Mechanisms of Caffeine Lijing Wang Linxi * Department Endocrinology Metabolism, Fujian Institute Endocrinology, Medical University Union Hospital, Fuzhou 350001, China Correspondence: [email protected] Received: 15 October 2024; Revised: 31 Accepted: 21 February 2025; Published: 1 April 2025 Abstract: is the most widely used psychoactive substance in world, present various beverages such as coffee, tea, energy drinks. Its basic chemical structure contains methylxanthine active components. As a non-selective central adenosine receptor antagonist, caffeine exerts broad range pharmacological effects, including antioxidant, anti-inflammatory, neuroprotective functions. Epidemiological studies clinical reports suggest that consumption closely associated with reduced risk neurodegenerative diseases Alzheimer’s disease, Parkinson’s dementia. Additionally, has shown potential benefits regulating cognitive function, improving depressive symptoms, reducing stroke. Although mechanisms remain unclear, current research revealed it its effects through multiple signaling pathways, inhibition A2A receptors, suppression neuroinflammation, modulation synaptic plasticity. This paper discusses recent advancements on explores applications stroke, depression.

Язык: Английский

Процитировано

0
Trelagliptin Ameliorates Memory Decline in Diabetic Rats through the AMPK/AKT/GSK-3β Pathway in the Cerebral Cortex DOI Creative Commons

Yue Yao,

Ting Shu,

Xiying Guo

и другие.

ACS Omega, Год журнала: 2025, Номер 10(15), С. 15673 - 15680

Опубликована: Апрель 11, 2025

Examining how hypoglycemic medications affect brain function is one of the best approaches to addressing cognitive impairment. In this study, trelagliptin, a dipeptidyl peptidase-4 (DPP4) inhibitor, was utilized assess memory loss in diabetic rats through fear conditioning tests. Trelagliptin restored that had been disrupted over relatively long period (24 h) or extended (5 days). Moreover, trelagliptin treatment reduced higher incidence neuronal cell death cerebral cortex, as observed via Nissl hematoxylin and eosin staining. Subsequent analyses revealed exhibited elevated levels inflammatory cytokines (p-IKKα p-NFκB) trend toward oxidative damage, indicated by malondialdehyde (MDA), superoxide dismutase 2 (SOD2), glutathione peroxidase 4 (GPX4) detection. However, administration reversed these markers baseline levels. Additionally, activated p-AMPK, p-AKT, p-GSK-3β. Notably, upregulated expression postsynaptic density protein 95 (PSD95) synaptotagmin 1 (SYT1) while downregulating amyloid precursor (APP) beta-site cleaving enzyme (BACE1). These findings suggest alleviates impairment rats, likely AMPK-AKT-GSK-3β-mediated mitigation stress, enhancement synaptic plasticity, reduction Aβ accumulation.

Язык: Английский

Процитировано

0
Coffee and Alzheimer's disease DOI
Foad Mirzaei,

Lila Agbaria,

Khushbu Bhatnagar

и другие.

Progress in brain research, Год журнала: 2024, Номер unknown, С. 21 - 55

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

2
Biotransformation of phytochemicals: Way forward to gut microbial, nutraceuticals and herbal therapeutics advancements DOI Creative Commons
Birbal Singh, Gorakh Mal, Rinku Sharma

и другие.

Functional Food Science - Online ISSN 2767-3146, Год журнала: 2024, Номер 4(3), С. 96 - 118

Опубликована: Март 25, 2024

Mammalian gastrointestinal tract is inhabited by trillions of symbiotic microbiotas representing viruses, bacteria, archaea and eukaryotes including yeasts, fungi protozoa. Compared to humans, the herbivores harbor a complex metabolically efficient microbes which not only detoxify inadvertently consumed anti-nutritional phytochemicals, but also convert ingested tannin-polyphenols, saponins, phytoestrogens alkaloids into metabolites are more available bioactive than their precursors. Some toxicants eliminate them from body. The resulting display range nutritional therapeutic benefits besides direct impact on enhancing diversity functioning gut microbiome. Metabolically active microbiota generated might be futuristic alternative biotherapeutics develop nutraceuticals plant-based health formulations primarily for ‘metabotype 0’ individuals. Further insights novel microbial species, modes biotransformation phytochemicals botanicals will pave way non-antibiotic interventions avert infections boost human veterinary health. Keywords: Gut microbiome; Phytochemicals; Biotransformation; Biotherapeutics Highlights: dietary prevent host against chronic diseases infections. Little known about metabolism action GI herbal supplements. having anti-inflammatory, anti-oxidative anti-carcinogenic properties therapeutics.

Язык: Английский

Процитировано

1