Glutathione-responsive FA-CMC-GNA nanoparticles: a novel approach for enhanced delivery of gambogenic acid in lung cancer treatment

Advanced Composites and Hybrid Materials, Год журнала: 2025, Номер 8(1)

Опубликована: Фев. 1, 2025

Язык: Английский

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Advances in cellulose-based hydrogels: tunable swelling dynamics and their versatile real-time applications

RSC Advances, Год журнала: 2025, Номер 15(15), С. 11688 - 11729

Опубликована: Янв. 1, 2025

Cellulose-derived hydrogels have emerged as game-changing materials in biomedical research, offering an exceptional combination of water absorption capacity, mechanical resilience, and innate biocompatibility.

Язык: Английский

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Development of Deferoxamine-Functionalized Cyclodextrin Polymer for Targeted Iron Chelation

Опубликована: Янв. 1, 2025

Язык: Английский

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Comparative Study of Supercritical Fluid and Soxhlet Extraction of Inulin from Chicory Root (Cichorium Intybus L.): Optimization, Characterization, and Antioxidant Activity

Опубликована: Янв. 1, 2025

Язык: Английский

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Cyclodextrin-Based Chemically Modified pH-Responsive New Kind of Aldehyde-Functionalized Nanosponge Nanoparticles for Doxorubicin Hydrochloride Delivery

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106853 - 106853

Опубликована: Март 1, 2025

Язык: Английский

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Development of Deferoxamine‐Functionalized Cyclodextrin Polymer for Targeted Iron Chelation

ChemistryOpen, Год журнала: 2025, Номер unknown

Опубликована: Апрель 7, 2025

Polymeric systems are used in clinical settings to bind small molecules and ions. They show advantages pharmacokinetics reduced side effects compared low‐molecular‐weight agents. In this study, a cross‐linked β‐cyclodextrin polymer is functionalized with deferoxamine develop more efficient ways of delivering iron chelators. Deferoxamine well‐known chelator treat overload conditions. The resulting polymeric conjugate, an equal complexing capacity deferoxamine, showed significantly lower cytotoxicity free all cancer cell lines studied (neuroblastoma SHSY5Y, breast MDA‐MB‐231, ovarian adenocarcinoma A2780, lung A549). results demonstrate that the conjugation reduces toxicity at same reveals potential deferoxamine‐based cyclodextrin conjugates as novel approach for targeting dyshomeostasis.

Язык: Английский

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Encapsulation of NH2-MIL-101(Fe) with dialdehyde starch through Schiff-base imine: A development of a pH-responsive core-shell fluorescent nanocarrier for doxorubicin delivery

Carbohydrate Polymer Technologies and Applications, Год журнала: 2025, Номер unknown, С. 100794 - 100794

Опубликована: Апрель 1, 2025

Язык: Английский

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Targeted and intelligent nano-drug delivery systems for colorectal cancer treatment

Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 13

Опубликована: Апрель 25, 2025

Colorectal cancer (CRC) remains a highly heterogeneous malignancy with significant morbidity and mortality worldwide. Despite advancements in surgery, chemotherapy, immunotherapy, targeted therapy, treatment efficacy is often hampered by drug resistance systemic toxicity. In recent years, nano-drug delivery systems (NDDS) have emerged as promising strategy to enhance therapeutic precision, reduce adverse effects, overcome CRC treatment. This review discusses the NDDS for treatment, focusing on optimization of oral systems, development tumor-specific targeting strategies, design intelligent responsive tumor microenvironment (TME). Furthermore, we summarize current challenges translation explore future research directions enhancing their clinical feasibility impact.

Язык: Английский

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Review on biodegradable microsphere with special emphasis on inflammatory bowel disease & recent patents

Next Nanotechnology, Год журнала: 2025, Номер 7, С. 100184 - 100184

Опубликована: Янв. 1, 2025

Язык: Английский

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