Two-Dimensional Graphene Nanomaterials for Combined Photothermal and Chemotherapy-Enhanced Targeted Therapy of Breast Cancer
Опубликована: Янв. 1, 2025
Язык: Английский
Graphene Quantum Dots Attenuate TDP-43 Proteinopathy in Amyotrophic Lateral Sclerosis
ACS Nano,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 3, 2025
Aberrant
phase
separation-
and
stress
granule
(SG)-mediated
cytosolic
aggregation
of
TDP-43
in
motor
neurons
is
the
hallmark
amyotrophic
lateral
sclerosis
(ALS).
In
this
study,
we
found
that
graphene
quantum
dots
(GQDs)
potentially
modulate
during
SG
dynamics
separation.
The
intrinsically
disordered
region
C-terminus
exhibited
amyloid
fibril
formation;
however,
GQDs
inhibited
formation
fibrils
through
direct
intermolecular
interactions
with
TDP-43.
These
effects
were
accompanied
by
attenuation
ALS
phenotype
animal
models.
Additionally,
delayed
onset
survival
transgenic
mouse
models
enhancing
neuron
survival,
reducing
glial
activation,
neurons.
research,
demonstrated
efficacy
on
SG-mediated
binding
property
clinical
feasibility
using
several
other
types
caused
FUS
C9orf72.
Therefore,
could
offer
a
new
therapeutic
approach
for
proteinopathy-associated
ALS.
Язык: Английский
Two-dimensional graphene nanomaterials for combined photothermal and chemotherapy-enhanced targeted therapy of breast cancer
Materials Today Bio,
Год журнала:
2025,
Номер
unknown, С. 101668 - 101668
Опубликована: Март 1, 2025
Breast
cancer
is
one
of
the
most
common
malignant
tumors
in
women,
accounting
for
7-10
%
all
body.
Second
only
to
uterine
cancer,
it
poses
a
significant
threat
women's
health.
In
this
study,
two-dimensional
material
based
on
GO
nanoparticles
was
designed
combine
photothermal
therapy
(PTT)
with
chemotherapy
targeted
treatment
breast
cancer.
Firstly,
HPAA
grafted
onto
through
an
amide
reaction
after
EDC/NHS
activation.
Secondly,
RGD
attached
amino
group
HPAA.
Finally,
chemotherapeutic
drug
doxorubicin
loaded
intermolecular
interactions.
vitro
results
showed
that
HPAA/GO-RGD@DOX
exhibited
good
effect
and
release
profile,
greater
acidic
environments
compared
neutral
ones.
Additionally,
accelerated
apoptosis
tumor
cells
under
laser
irradiation.
Importantly,
vivo
experiments
demonstrated
HPAA/GO-RGD@DOX,
when
combined
irradiation,
effectively
site
inhibited
growth.
conclusion,
exhibits
high
targeting
efficiency
strong
effect.
This
study
suggests
composite
holds
great
promise
as
new
type
functional
2D
nanoparticle
capabilities
therapy.
Язык: Английский
Ultrasensitive electrochemical aptasensor based on PANI/GQDs for the detection of profenofos residues in vegetables
Microchemical Journal,
Год журнала:
2025,
Номер
unknown, С. 113572 - 113572
Опубликована: Апрель 1, 2025
Язык: Английский
Synthesis of folic acid, histidine and serine-functionalized and boron and phosphorus-doped graphene quantum dot with excellent yellow luminescence behavior in aqueous/solid state and its use for fluorescence detection of Fe2+ in urine
New Journal of Chemistry,
Год журнала:
2024,
Номер
48(34), С. 14984 - 14994
Опубликована: Янв. 1, 2024
Folic
acid,
histidine,
and
serine-functionalized
boron
phosphorus-doped
graphene
quantum
dot
with
excellent
yellow
luminescence
behavior
was
reported.
Язык: Английский
Graphene quantum dots as nanotherapeutic agents for triple-negative breast cancer: Insights from 3D tumor models
Coordination Chemistry Reviews,
Год журнала:
2024,
Номер
523, С. 216247 - 216247
Опубликована: Окт. 7, 2024
Язык: Английский
Carbon Quantum Dots in Biomedical Applications: Advances, Challenges, and Future Prospects
Aggregate,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 28, 2024
ABSTRACT
Carbon
quantum
dots
(CQDs)
represent
a
rapidly
emerging
class
of
nanomaterials
with
significant
potential
in
biomedical
applications
due
to
their
tunable
fluorescence,
high
biocompatibility,
and
versatile
functionalization.
This
review
focuses
on
the
recent
progress
utilizing
CQDs
for
drug
delivery,
bioimaging,
biosensing,
cancer
therapy.
With
unique
optical
properties,
such
as
yield,
photostability,
enable
precise
bioimaging
sensitive
biosensing.
Their
small
size,
ease
surface
functionalization
allow
development
targeted
delivery
systems,
enhancing
therapeutic
precision
minimizing
side
effects.
In
therapy,
have
shown
photodynamic
photothermal
treatments
by
generating
reactive
oxygen
species
under
light
exposure,
selectively
targeting
cells
while
sparing
healthy
tissues.
Furthermore,
CQDs’
ability
penetrate
biological
barriers
including
blood–brain
barrier
opens
new
possibilities
delivering
agents
hard‐to‐reach
areas,
tumors
or
diseased
However,
challenges
optimizing
synthesis,
ensuring
long‐term
stability,
addressing
safety
concerns
environments
remain
critical
hurdles.
discusses
current
efforts
overcome
these
improve
CQD
performance
clinical
settings,
scalable
production
methods
enhanced
biocompatibility.
As
research
progresses,
are
expected
play
an
important
role
improving
healthcare
offering
more
treatment
options
contributing
advancements
personalized
medicine.
Язык: Английский
Graphene Quantum Dots‐Based Materials as an Emerging Nanoplatform in Disease Diagnosis and Therapy
Particle & Particle Systems Characterization,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 14, 2024
Abstract
Graphene
quantum
dots
are
a
subclass
of
graphene‐based
materials
that
exhibit
unique
properties
due
to
their
nanoscale
size
and
confinement
effects.
Discovered
in
the
early
21st
century,
these
zero‐dimensional
carbon
nanomaterials
have
rapidly
become
important
nanotechnology
research
diverse
applications.
In
recent
years,
medical
community
has
been
greatly
benefited
from
materials,
significantly
enhancing
human
health
well‐being
with
theranostic
approaches.
The
present
review
explores
various
applications
graphene
diagnostic
therapeutic,
unraveling
potential
contributions
advancing
healthcare.
Furthermore,
this
elucidates
synthesis
methods
utilized
for
dots,
encompassing
range
top‐down
bottom‐up
Next,
fundamental
including
structural,
optical,
electrical
make
them
potent
nanomaterial
use
healthcare
elucidated
enhanced
reader
comprehension.
Additionally,
opportunities
challenges
ahead,
offering
valuable
insights
help
scientific
strategically
expand
dot‐based
advanced
Язык: Английский
Nanocomposites of Thermosetting Polymers and Graphene Quantum Dots—Physical Attributes and Ongoing Progressions
Journal of Macromolecular Science Part B,
Год журнала:
2024,
Номер
unknown, С. 1 - 23
Опубликована: Окт. 10, 2024
Thermosets,
before
hardening,
consist
of
independent
macromolecules
similar
to
thermoplastics,
however,
chemical
curing
these
via
heat
or
radiations
may
form
irreversibly
crosslinked
macromolecular
networks
between
their
main
chains.
Graphene
quantum
dots
are
inimitable
spherical
nano-entities
having
the
advantages
extremely
small
sizes,
5-10
nm,
very
high
surface
area,
surface/edge
effects,
confinements
and
a
range
physical
characteristics
including
semiconductivity,
fluorescence
magnetic
properties.
Similar
other
nanocarbons
(like
graphene,
fullerene
nanodiamonds),
graphene
have
been
examined
as
noteworthy
nanofillers
enhance
essential
features
various
matrices,
such
thermosets,
thermoplastics
rubbers.
Consequently,
this
review
article
was
intended
systematically
discuss
existing
scientific
state
reinforced
thermosetting
matrices
for
formation
performance
nanomaterials.
According
literature
reports,
type,
amount
molecular
weight
seemed
affect
epoxy-quantum
interactions
properties,
like
strength
stability
resulting
Moreover,
in
epoxies,
hyperbranched
polyesters
polyurethanes,
has
positively
influenced
engineering
aspects
(mainly
mechanical
thermal
attributes)
nanocomposites
owing
interactions,
compatibility
interfacial
tendencies
toward
matrices.
Principally,
epoxy/graphene
fabricated
investigated
effects
on
property
enhancements
due
mutual
matrix-nanofiller
interfaces.
As
per
our
analysis,
hitherto
matrix
disclosed
significant
improvements
promising
technological
applications
anticorrosion
coatings,
electromagnetic
interference
shields
biomedical
fields.
Язык: Английский