Process optimizations for the synthesis of an intermediate of dydrogesterone
RSC Advances,
Год журнала:
2025,
Номер
15(10), С. 7656 - 7662
Опубликована: Янв. 1, 2025
This
works
develops
an
efficient
three-step
synthesis
of
dydrogesterone
intermidiate
9α,10β-pregest-5,7-diene-3,20-diethylene
glycol
ketone
through
ketal
production,
innovative
photoinitiated
allylic
bromination,
and
elimination.
Язык: Английский
Synthesis of Alkyl Sulfones via a Photocatalytic Multicomponent Reaction of Aryldiazo Tetrafluoroborate Salts, Styrene Derivatives, and Sodium Metabisulfite
Organic & Biomolecular Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 25, 2024
Practical
visible-light-induced
synthesis
of
alkyl
sulfones
has
been
achieved
via
a
multicomponent
reaction
aryldiazo
tetrafluoroborate
salts,
styrene
derivatives,
thiophenol
and
sodium
metabisulfite
in
the
presence
rhodamine
B.
Язык: Английский
Macroscopic alignment of metal–organic framework crystals: recent advances and perspectives on sustainability
Green Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 6, 2024
We
review
in
situ
and
post-synthetic
methods
for
controlling
the
orientation
of
metal–organic
frameworks.
This
highlights
recent
achievements
approaches
their
implications
sustainability
green
technologies.
Язык: Английский
Harnessing Photoredox and Weak Brønsted Base Dual Catalysis for Selective C(sp3)–H Bond Activation
Synthesis,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 10, 2024
Abstract
Visible
light
photoredox
and
weak
Brønsted
base
dual
catalysis
has
emerged
as
a
powerful
versatile
tool
in
the
activation
of
C(sp3)–H
bonds
under
mild
reaction
conditions.
This
method
allows
for
selective
functionalization
wide
range
substrates,
including
amines,
sulfides,
ethers,
dithianes
dithiolanes,
dioxolanes,
alkenes.
By
exploiting
increased
acidity
C–H
following
single
electron
oxidation,
this
strategy
employing
catalyst
facilitates
various
carbon–carbon
bond-forming
reactions,
well
rearrangements,
with
high
efficiency
regioselectivity.
review
highlights
recent
advancements
field,
emphasizing
underlying
mechanisms
broad
applicability
these
methodologies
organic
synthesis.
1
Introduction
2
Activation
α-C(sp3)–H
Bonds
N-,
S-,
O-Containing
Compounds
C–C
Bond
Formation
3
Allylic
4
Photoredox
Base
Dual
Catalysis
Rearrangement
Reactions
5
Conclusion
Язык: Английский
Micelle-enabled Bromination of α-Oxo Ketene Dithioacetals: Mild and Scalable Approach via Enzymatic Catalysis
Organic & Biomolecular Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 26, 2024
The
bromination
of
α-oxo
ketene
dithioacetals
using
KBr/H2O2,
catalyzed
by
Curvularia
inaequalis
vanadium
chloroperoxidase
(CiVCPO),
has
been
successfully
demonstrated.
A
comparative
study
enzymatic
processes
"on
water"
versus
"in
water",
2
wt%
the
surfactant
TPGS-750-M
revealed
that
in-water
protocol
not
only
provides
higher
yields
but
also
accommodates
a
broader
substrate
scope.
This
method
in
an
aqueous
micellar
medium
enabled
preparation
brominated
fair
to
excellent
(23
examples).
In
system,
concentration
was
increased
up
50
mM,
and
amounts
brominating
agents
KBr
H2O2
were
reduced
approximately
2.0
equivalents
without
compromising
efficiency.
Notably,
this
process
allows
for
gram-scale
high
yields.
Key
advantages
include
its
benign
eco-friendly
nature,
use
water
as
green
solvent,
potential
large-scale
production
dithioacetals.
Язык: Английский