Medicinski pregled,
Год журнала:
2024,
Номер
77(7-8), С. 241 - 247
Опубликована: Янв. 1, 2024
Introduction.
Despite
significant
advancements
in
materials
for
permanent
restorations,
there
is
still
no
material
that
fully
replicates
the
physical,
chemical,
and
biological
properties
of
dental
tissues.
Contemporary
research
adhesive
dentistry
focuses
on
achieving
a
reliable
durable
bond
between
restorative
substrates.
This
paper
aims
to
present
recent
innovations
technology
focused
improving
challenging
dentin.
Currently,
several
key
strategies
address
this
issue,
including
application
collagen
cross-linkers,
antioxidants,
inhibitors
endogenous
proteinases,
reinforcement
with
inorganic
fillers
remineralization
agents,
modifications
bonding
techniques,
substrate
treatment
using
lasers.
Conclusion.
Current
knowledge
experimental
findings
suggest
modern
methods
modifying
dentin
can
achieve
satisfactory
initial
bond.
However,
degradation
interfacial
contact
surface
remains
challenge,
compromising
long-term
durability
restorations.
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 22, 2025
As
one
of
the
most
promising
means
to
repair
diseased
tissues,
stem
cell
therapy
with
immense
potential
differentiate
into
mature
specialized
cells
has
been
rapidly
developed.
However,
clinical
application
stem-cell-dominated
regenerative
medicine
was
heavily
hindered
by
loss
pluripotency
during
long-term
in
vitro
expansion.
Here,
a
composite
three-dimensional
(3D)
graphene-based
biomaterial,
denoted
as
GO-Por-CMP@CaP,
hierarchical
pore
structure
(micro-
macropore),
developed
guide
directional
differentiation
human
umbilical
cord
MSCs
(hucMSCs)
osteoblasts.
GO-Por-CMP@CaP
could
act
high-efficiency
living
material
without
"dead
space",
effectively
regulating
cellular
response.
The
3D
topological
generated
via
two-step
modification
on
two-dimensional
graphene
mimic
natural
microenvironment
cells,
enhancing
attachment,
which
is
not
only
conducive
for
proliferation
but
also
beneficial
osteogenic
differentiation.
Meanwhile,
wide
existence
interconnected
macropores
favorable
bone
ingrowth,
capillary
formation,
well
nutrients
transportation.
Furthermore,
concurrent
micro-
and
mesopores
significantly
promoted
extracellular
matrix
(ECM)
adsorption,
ensured
leading
multiscale
osteointegration.
Both
vivo
assay
demonstrated
above
three
factors
collaborated
mutually
nanosized
calcium
phosphate
(CaP,
chemical
similarities
inorganic
components
bone),
provided
abundant
adhesive
sites
adequately
induce
absence
any
soluble
growth
factors.
Proteomic
analysis
experiments
confirmed
that
hucMSCs
osteoblasts
affecting
PI3K-Akt
signaling
pathway
through
up-regulation
SPP1
protein.
Our
study
offers
pure
material-based
behavior
engineering
dimension
porosity
material,
provides
insights
design
development
substitutes
materials.
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 7, 2025
Abstract
Implant‐associated
infections
are
the
most
critical
threat
to
orthopedic
surgeries.
Various
surface‐modification
strategies
developed
impart
antibacterial
properties
and
osteogenesis‐promoting
abilities
surfaces
of
implants.
Nevertheless,
a
straightforward
strategy
for
constructing
functional,
stable,
bioactive
implant
surface
remains
challenging.
Here,
facile
one‐step
surface‐bioactivation
method
is
that
enhances
both
anti‐infection
capabilities
osteointegration
performance
This
approach
utilized
kind
coating
integrates
agents
components
directly
onto
titanium
The
cationic
agent
bone‐adhesion‐enhancing
peptide
covalently
attached
via
Michael
reaction
poly
(tannic
acid)
(PTA)
create
dual‐functional
implants
(Ti‐PR).
Ti‐PR
effectively
eliminated
more
than
99%
common
pathogenic
bacteria
significantly
enhanced
osteogenic
differentiation
bone
marrow
mesenchymal
stem
cells
(BMSCs)
in
vitro.
cell‐bacteria
competitive
culture
assay
on
confirms
its
bactericidal
cell
proliferation‐promoting
properties.
Additionally,
RNA‐Seq
analysis
indicated
PI3K/Akt
pathways
played
crucial
role
enhancing
BMSCs.
superior
osteogenesis
performances
confirmed
an
implant‐related
infection
model
vivo.
study
provided
efficient
design
production
innovative
multifunctional
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 11, 2025
Abstract
The
hyperglycemic
microenvironment
of
diabetes
inevitably
leads
to
the
accumulated
reactive
oxygen
species
(ROS)
and
impairs
function
stem
cells,
thereby
impeding
process
osseointegration
after
implant
placement.
In
this
study,
a
self‐assembled
metal‐phenolic
nanozyme
coating
is
presented
for
alleviating
diabetic
oxidative
stress
improving
at
interfaces.
antioxidant‐like
enzyme
activity
induced
by
phenolic
ligand−metal
charge
transfer
(LMCT)
during
coordination
epigallocatechin‐3‐gallate
(EGCG)
with
copper
phosphate
nanosheets
(Cu
NS).
biointerfaces
exhibits
scavenging
against
range
free
radicals
facilitated
adhesion,
migration,
osteogenic
differentiation
enhancing
implants
in
rats.
Additionally,
strategy
inhibits
bacterial
invasion
supports
adhesion
soft
tissue
cells.
This
study
provides
prospective
approach
surface
modification
safeguard
enhance
subjects.
Abstract
Human
tooth
enamel,
consisting
of
hydroxyapatite
nanocrystals
(∼85–88
vol%),
proteins
(∼2‐3
and
requisite
water
(∼10–12
is
1–3
mm
thick
at
the
outer
layer
tooth.
It
possesses
remarkable
properties
such
as
high
stiffness,
hardness,
strength,
viscoelasticity.
However,
when
enamel
undergoes
deterioration
due
to
various
factors,
including
unhealthy
dietary
habits,
wear
tear
others,
it
progresses
from
surface
stains
loss,
ultimately
necessitating
entire
replacement.
This
because
lacks
ability
generate
cells
on
damaged
side
after
eruption,
preventing
self‐repair.
Thus,
repair
materials
are
in
urgent
demand,
but
clinical
restorative
nowadays
cannot
fully
replicate
microstructure
function
natural
enamel.
Numerous
efforts
have
been
made
develop
next
generation
for
address
different
types
damage,
stains,
defects,
loss.
Here,
we
introduce
fundamental
characteristics
beginning.
Then,
provide
a
summary
preparation
process
existing
based
defects
detail.
Finally,
suggestions
development
directions
field
restoration
presented,
with
aim
providing
theoretical
reference
creation
that
better
match
Journal of Composites Science,
Год журнала:
2025,
Номер
9(3), С. 140 - 140
Опубликована: Март 17, 2025
Since
tooth
loss
is
a
common
problem
in
humans
and
widespread
worldwide,
dental
implants
are
an
effective
optimal
alternative
to
solve
this
problem.
Thus,
it
necessary
develop
with
improved
surfaces
that
favor
the
osseointegration
of
implant
into
surrounding
tissues
promote
cell
adhesion
proliferation
while
also
preventing
inhibiting
peri-implant
infections
can
lead
failure.
In
regard,
review
aims
provide
new
insights
nanotechnology
use
nanoparticles
creating
coatings,
trends
for
enhancing
surfaces,
current
technologies
used
purpose.
Although
vitro
vivo
tests
attest
possible
nanomaterials
described
review,
further
needed
establish
concentrations
be
safe
clinical
trials.
Abstract
Owing
to
the
tooth‐centered
nature
of
most
oral
diseases,
tooth‐centric
radial
plane
cone‐beam
computed
tomography
(CBCT)
depicts
anatomical
and
pathological
features
along
long
axis
tooth,
serving
as
a
crucial
imaging
modality
in
diagnosis,
treatment
planning,
prognosis
multiple
diseases.
However,
reconstructing
these
standard
planes
from
CBCT
is
labor‐intensive,
time‐consuming,
error‐prone
due
variances
multi‐center
discrepancies.
This
study
proposes
an
expertise‐inspired
artificial
intelligence
(AI)
pipeline
for
reconstruction
plane.
By
emulating
expert's
workflow,
this
AI
acquires
optimized
maxillary
mandibular
cross
sections,
segments
teeth
dental
arch
curve
depiction,
reconstructs
arch‐defined
planes.
A
total
420
scans
two
independent
centers,
comprising
both
healthy
diseased
subjects,
were
collected
model
development
validation.
Teeth
on
sections
explicitly
segmented
even
presence
various
complex
resulting
precise
depictions.
The
AI‐reconstructed
all
exhibited
low
angular
distance
errors
compared
with
ground
truth
In
terms
clinical
utility,
demonstrated
high
image
quality,
accurately
represented
features,
facilitated
biometrics
measurement
by
clinicians
downstream
diagnostic
tools.
showcases
outstanding
performance
offers
significant
utility
intelligent
health
management
interpretability,
robustness
generalization
capabilities.
Materials,
Год журнала:
2024,
Номер
17(21), С. 5166 - 5166
Опубликована: Окт. 23, 2024
Surface
modifications
not
only
improve
the
corrosion
resistance
of
Co-Cr-Mo
dental
alloys
(Bego
Wirobond®
C)
but
also
ensure
their
long-term
performance
and
reliability
in
applications.
This
paper
describes
preparation
single-layer
TiO2-ZrO2
sol–gel
coatings
on
alloy
using
method
dip-coating.
The
were
sintered
at
300
500
°C.
SEM
analysis
shows
that
sintering
°C
produces
a
uniform,
slightly
dense
structure
without
micro-cracks,
while
results
denser
with
micro-cracks
due
to
higher
stress
shrinkage.
EDS
confirms
temperature
affects
elemental
composition
coating,
temperatures
causing
volatilization
or
diffusion
Ti
Zr.
Roughness
measurements
indicate
Ra
value
increases
temperature,
meeting
application
requirements.
Electrochemical
by
open-circuit
potential,
EIS,
cyclic
potentiodynamic
curves
demonstrate
saliva
affect
resistance,
NaF
mouthwashes
(Listerine
Total
Care
Teeth
Protection®
Meridol®)
generally
increasing
charge
transfer
double-layer
capacitance.
ceramic
significantly
reduce
pitting
susceptibility
physiological
acidic
pH,
coating
showing
better
protective
properties.
These
findings
highlight
potential
enhancing
alloys.
