Choroid plexus volumes and auditory verbal learning scores are associated with conversion from mild cognitive impairment to Alzheimer's disease
Brain and Behavior,
Год журнала:
2024,
Номер
14(7)
Опубликована: Июль 1, 2024
Abstract
Purpose
Mild
cognitive
impairment
(MCI)
can
be
the
prodromal
phase
of
Alzheimer's
disease
(AD)
where
appropriate
intervention
might
prevent
or
delay
conversion
to
AD.
Given
this,
there
has
been
increasing
interest
in
using
magnetic
resonance
imaging
(MRI)
and
neuropsychological
testing
predict
from
MCI
Recent
evidence
suggests
that
choroid
plexus
(ChP),
neural
substrates
implicated
brain
clearance,
undergo
volumetric
changes
Whether
ChP
is
involved
memory
observed
used
AD
not
explored.
Method
The
current
study
data
Disease
Neuroimaging
Initiative
(ADNI)
database
investigate
whether
later
progression
(progressive
[pMCI],
n
=
115)
stable
(sMCI,
338)
was
associated
with
scores
Rey
Auditory
Verbal
Learning
Test
(RAVLT)
volumes
as
calculated
MRI.
Classification
analyses
identifying
pMCI
sMCI
group
membership
were
performed
compare
predictive
ability
RAVLT
volumes.
Finding
results
indicated
a
significant
difference
between
groups
for
right
volume,
showing
significantly
larger
volume
(
p
.01,
95%
confidence
interval
[−.116,
−.015]).
A
linear
relationship
found
across
all
participants,
but
two
separately.
showed
combination
left
auditory
verbal
learning
resulted
most
accurate
classification
performance,
accurately
predicted
72%
data.
Conclusion
These
suggest
appear
occur
before
onset
provide
value
predicting
Язык: Английский
The Relationship Between Reduced Hand Dexterity and Brain Structure Abnormality in Older Adults
Geriatrics,
Год журнала:
2024,
Номер
9(6), С. 165 - 165
Опубликована: Дек. 17, 2024
Background:
Hand
dexterity
is
affected
by
normal
aging
and
neuroinflammatory
processes
in
the
brain.
Understanding
relationship
between
hand
brain
structure
neurotypical
older
adults
may
be
informative
about
prodromal
pathological
processes,
thus
providing
an
opportunity
for
earlier
diagnosis
intervention
to
improve
functional
outcomes.
Methods:
this
study
investigates
associations
measures
(≥65
years)
using
Nine-Hole
Peg
Test
(9HPT)
magnetic
resonance
imaging
(MRI).
Results:
Elastic
net
regularized
regression
revealed
that
reduced
dominant
non-dominant
hands
was
associated
with
enlarged
volume
of
left
choroid
plexus,
region
implicated
altered
myelination
myelin
content
frontal
operculum,
motor
imagery,
action
production,
higher-order
functions.
Distinct
neural
mechanisms
underlying
included
differences
caudate
thalamic
volumes
as
well
cortical
patterns
frontal,
temporal,
parietal,
occipital
regions
supporting
sensorimotor
visual
processing
integration,
attentional
control,
eye
movements.
Although
elastic
identified
more
predictive
features
vs.
hand,
feature
stability
higher
latter,
indicating
generalizability
model.
Conclusions:
Our
findings
suggest
9HPT
might
a
cost-effective
screening
tool
early
detection
neurodegenerative
processes.
Longitudinal
studies
are
needed
validate
our
larger
sample
explore
potential
clinical
marker.
Язык: Английский
The relationship between brain structure and reduced hand dexterity in older adults
medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 12, 2024
ABSTRACT
Hand
dexterity
is
affected
by
normal
aging
and
neuroinflammatory
processes
in
the
brain.
Understanding
relationship
between
hand
brain
structure
neurotypical
older
adults
may
inform
about
prodromal
pathological
processes,
thus
providing
an
opportunity
for
earlier
diagnosis
intervention
to
improve
functional
outcomes.
This
study
investigates
associations
measures
(≥65
years)
using
Nine
Hole
Peg
Test
(9HPT)
magnetic
resonance
imaging
(MRI).
Elastic
net
regularized
regression
revealed
that
reduced
dominant
non-dominant
hands
was
associated
with
enlarged
volume
of
left
choroid
plexus,
region
implicated
altered
myelination
myelin
content
frontal
operculum,
motor
imagery,
action
production,
higher-order
functions.
Distinct
neural
mechanisms
underlying
included
differences
caudate
thalamic
volumes
as
well
cortical
patterns
frontal,
temporal,
parietal,
occipital
regions
supporting
sensorimotor
visual
processing
integration,
attentional
control,
eye
movements.
Although
elastic
identified
more
predictive
features
vs.
hand,
feature
stability
higher
latter,
indicating
generalizability
model.
Our
findings
suggest
9HPT
serve
a
cost-effective
screening
tool
early
detection
neurodegenerative
processes.
Longitudinal
studies
are
needed
validate
our
larger
sample
explore
potential
clinical
marker.
Язык: Английский
Evidence for reduced choroid plexus volume in the aged brain
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 16, 2024
Abstract
Background
The
choroid
plexus
plays
an
important
role
in
brain
homeostasis,
including
the
active
secretion
of
cerebrospinal
fluid.
Its
function
and
structure
have
been
reported
to
be
affected
by
normal
ageing.
However,
existing
measures
volume
may
complicated
partial
(
vivo
MRI)
tissue
fixation
artefacts
(histology).
In
this
study,
we
investigate
possible
changes
within
lateral
ventricles
aged
mice
utilising
two
structural
MRI
protocols
explicitly
designed
for
time-efficient,
high-resolution
imaging
plexus.
Methods
Two
sequences
were
utilised
examine
young
(∼6
months)
(∼24
mouse
brains:
1)
ultra-long
echo-time
T2
weighted
fast-spin-echo
2)
a
multi-TE
T2*
mapping
protocol.
A
test-retest
study
was
performed
on
subset
data
reproducibility
estimation.
two-way
ANOVA
test
determine
differences
groups
across
distinct
protocols.
Results
Reproducibility
tests
showed
low
variability
manual
segmentation
pipeline
both
statistically
significant
reduction
found
brain.
This
finding
is
concordant
with
previous
histology
studies
that
observed
epithelial
cell
height
ageing
wide
range
species.
Conclusions
We
present
investigation
ventricle
approach
based
bespoke
time-efficient
high
resolution
Furthermore,
these
protocols,
provide
evidence
research
provides
insight
measurements
as
biomarker
age-related
neurologic
conditions
it
indicates
process
itself
does
not
result
hypertrophy
plexus,
but
decrease
volume.
Язык: Английский