Targeting the Sirtuin–1/PPAR–Gamma Axis, RAGE/HMGB1/NF-κB Signaling, and the Mitochondrial Functions by Canagliflozin Augments the Protective Effects of Levodopa/Carbidopa in Rotenone-Induced Parkinson’s Disease DOI Creative Commons
M.H.R. El-Kady, Ahmed M. Kabel, Lamees M. Dawood

и другие.

Medicina, Год журнала: 2024, Номер 60(10), С. 1682 - 1682

Опубликована: Окт. 14, 2024

Parkinson's disease (PD) is a pathological state characterized by combined set of abnormal movements including slow motion, resting tremors, profound stiffness skeletal muscles, or obvious abnormalities in posture and gait, together with significant behavioral changes. Until now, no single therapeutic modality was able to provide complete cure for PD. This work trial assess the immunomodulatory effects canagliflozin without levodopa/carbidopa on rotenone-induced parkinsonism Balb/c mice.

Язык: Английский

Targeting the Sirtuin–1/PPAR–Gamma Axis, RAGE/HMGB1/NF-κB Signaling, and the Mitochondrial Functions by Canagliflozin Augments the Protective Effects of Levodopa/Carbidopa in Rotenone-Induced Parkinson’s Disease DOI Creative Commons
M.H.R. El-Kady, Ahmed M. Kabel, Lamees M. Dawood

и другие.

Medicina, Год журнала: 2024, Номер 60(10), С. 1682 - 1682

Опубликована: Окт. 14, 2024

Parkinson's disease (PD) is a pathological state characterized by combined set of abnormal movements including slow motion, resting tremors, profound stiffness skeletal muscles, or obvious abnormalities in posture and gait, together with significant behavioral changes. Until now, no single therapeutic modality was able to provide complete cure for PD. This work trial assess the immunomodulatory effects canagliflozin without levodopa/carbidopa on rotenone-induced parkinsonism Balb/c mice.

Язык: Английский

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