Prevalence, spectrum, and the relations between short-term and long-term post-acute sequelae of COVID-19 in children

Journal of microbiology epidemiology immunobiology, Год журнала: 2025, Номер 102(1), С. 43 - 61

Опубликована: Март 30, 2025

Background. Data on the prevalence of post-COVID-19 condition (PCC) in children differ due to lack specific diagnostic criteria, reliable biomarkers, and limitations many studies. It is important study association between PCC, previous functional disorders, any events post-acute period COVID-19 estimate true burden PCC children. The aim. To determine relation initial disorders during year after a mild form acute respiratory tract infections (ARTI) other etiologies. Materials methods. prospective using continuous sampling method included under 18 years age hospitalized with suspected COVID-19, whom was confirmed by RT-PCR (n = 121) or excluded molecular serological methods (ARTI group, n 105). Information patients collected from September 2020 December 2021 questionnaires at index points: hospital discharge 1, 3, 6 12 months. Severe chronic diseases were excluded. Functional anamnesis associated health observation, severity symptoms taken into account. analysis performed groups ≥ age. Symptoms grouped clusters. Results. Any identified frequency 32–39% (in ≥6 years, respectively). most common psycho-emotional, autonomic dysfunction (AD) cluster. cases duration 3–6 After adjustment for age, AD history recurrent ARTI episodes, no difference found symptom clusters except hyposmia, incidence which decreased 14.3% first point 2.4% one year. Among without an year, de novo rare phenomenon (2.7–8.0%) differences controls. risks significantly increased (adjusted OR 1 month 3.19 (95% CI 1.89–5.38), months 3.33 1.81–6.15)). Multiple (5–25) persistent (at all points) rated as significant occurred rarely (1.7% 0.4–4.9)), but more often — 25%) 95% 13.6–39.6%) (difference 23.3% (10.9–35.7%), 14.8 (4.4–50.6), p 0.001). Recurrent episodes risk factor increase cognitive cluster complaints vagotonic observation. Conclusion. results obtained indirectly support concept that somatoform disorder, probably sociogenic nature, who are anxious baseline. Some consequences really need medical psychosocial rehabilitation. provides new insights widespread viral infections.

Язык: Английский

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Internal medicine at the crossroads of long COVID diagnosis and management

Frontiers in Medicine, Год журнала: 2025, Номер 12

Опубликована: Май 2, 2025

The lack of specificity in its definition is a major obstacle to both explanatory and therapeutic research long COVID. It brings together, on the one hand, patients with severe COVID-19 who suffer classic complications prolonged hospitalization decompensation comorbidities and, other non-severe acute report multiple symptoms that cannot be fully explained by biomechanical model. Indeed, despite numerous studies, it remains unclear how persistent viral infection, immunological or coagulation disturbances may contribute mechanistically Nevertheless, internal medicine should good place manage these patients. diversity evoke broad spectrum differential diagnoses are familiar internists. Their experience exploration unexplained also valuable. can reduce need for consultations specialists unnecessary laboratory imaging tests. However, COVID diagnosis limited exclusion all conditions one. An open non-dualistic approach required identify mechanisms explain symptoms. Based their clinical experience, most French internists responded an opinion survey consider corresponds closely functional somatic disorder (FSD) seek help mental health care assist management multi-disciplinary approach. as FSDs, usually reluctant managed specialists, given very physical nature presentation. Unfortunately, physicians turn take them, due poor knowledge about FSD, leading failure. Alternatively, comprehensive multidisciplinary orchestrated experienced internist generally well-accepted. includes providing rational cognitive explanations support behavioral changes tailored patient. While waiting hypothetical randomized controlled trials assessing drugs positive results, such holistic has been successfully applied many individuals generalization would require much broader training FSD providers.

Язык: Английский

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A review of the sequelae of post Covid-19 with neurological implications (post-viral syndrome)

Journal of the Neurological Sciences, Год журнала: 2025, Номер unknown, С. 123532 - 123532

Опубликована: Май 1, 2025

Язык: Английский

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