Frontiers in Medicine, Год журнала: 2024, Номер 11
Опубликована: Авг. 2, 2024
Preclinical research has identified the mechanisms via which bacteria influence cancer treatment outcomes. Clinical studies have demonstrated potential to modify microbiome in treatment. Herein, we systematically analyze how gut microorganisms interact with chemotherapy and immune checkpoint inhibitors, specifically focusing on affect pharmacokinetics pharmacodynamics of
Язык: Английский
International Journal of Biological Sciences, Год журнала: 2022, Номер 18(13), С. 4932 - 4949
Опубликована: Янв. 1, 2022
Little is known about the oncogenic role or biological function of copine Ⅷ (CPNE8) in gastric cancer (GC).Based on TCGA database, we screened for CPNE8 and analyzed expression GC.The correlations between clinical features were using GEO databases.The prognostic value was assessed Cox analysis Kaplan-Meier curves.The results showed that increased positively correlated with metastasis can be considered an independent risk factor poor survival.We found promote cell proliferation, migration, invasiveness GC vitro vivo experiments.Our study demonstrated promotes tumor progression via regulation focal adhesion, these effects rescued by adhesion kinase (FAK) inhibitor GSK2256098 knockdown FAK.In addition, significantly infiltration cancer-associated fibroblasts immune cells, as various algorithms, high predicted efficacy checkpoint therapy.Our findings suggest modulates microenvironment to could serve a novel biomarker GC.
Язык: Английский
Процитировано
26
Nutrients, Год журнала: 2023, Номер 15(6), С. 1344 - 1344
Опубликована: Март 10, 2023
Dietary and genetic factors are considered to be associated with UGI cancer risk. However, examinations of the effect healthy diet on risk extent which modifies impact susceptibility remains limited. Associations were analyzed through Cox regression UK Biobank data (n = 415,589). Healthy diet, based "healthy score," was determined according fruit, vegetables, grains, fish, meat consumption. We compared adherence cancer. also constructed a polygenic score (UGI-PRS) assess combined diet. For results high reduced 24% (HR high-quality diet: 0.76 (0.62-0.93), p 0.009). A unhealthy observed, HR reaching 1.60 (1.20-2.13, 0.001). Among participants risk, absolute five-year incidence significantly reduced, from 0.16% 0.10%, by having In summary, decreased individuals can attenuate adopting
Язык: Английский
Процитировано
16
Pathology - Research and Practice, Год журнала: 2024, Номер 255, С. 155216 - 155216
Опубликована: Фев. 16, 2024
Язык: Английский
Процитировано
5
International Immunopharmacology, Год журнала: 2024, Номер 137, С. 112433 - 112433
Опубликована: Июнь 13, 2024
Gastric cancer (GC) is a refractory malignant tumor with high heterogeneity, low rate of early diagnosis, and poor patient prognosis. Lipid metabolism reprogramming plays critical role in tumorigenesis progression, but its prognostic regulatory mechanism GC are rarely studied. Thus, the identification signatures related to lipid necessary may present new avenue for improving overall prognosis GC.
Язык: Английский
Процитировано
5
Frontiers in Medicine, Год журнала: 2024, Номер 11
Опубликована: Авг. 2, 2024
Preclinical research has identified the mechanisms via which bacteria influence cancer treatment outcomes. Clinical studies have demonstrated potential to modify microbiome in treatment. Herein, we systematically analyze how gut microorganisms interact with chemotherapy and immune checkpoint inhibitors, specifically focusing on affect pharmacokinetics pharmacodynamics of
Язык: Английский
Процитировано
5