Journal of Clinical Medicine,
Год журнала:
2024,
Номер
13(12), С. 3460 - 3460
Опубликована: Июнь 13, 2024
Background:
Glioblastoma
is
a
primary
malignant
brain
tumor;
it
aggressive
with
high
degree
of
malignancy
and
unfavorable
prognosis
the
most
common
type
tumor.
Glioblastomas
can
be
located
in
brain,
cerebellum,
brainstem,
spinal
cord,
originating
from
glial
cells,
particularly
astrocytes.
Methods:
The
databases
MEDLINE,
Scopus,
Web
Science,
Google
Scholar,
CINAHL
were
researched
up
to
January
2024.
Two
authors
independently
performed
search,
study
selection,
data
extraction.
Methodological
quality
was
evaluated
an
assurance
tool
for
anatomical
studies
(AQUA).
statistical
mean,
standard
deviation,
difference
means
calculated
Student’s
t-test
presence
between
hemispheres
frontal
temporal
lobes
analyzed.
Results:
A
total
123
met
established
selection
criteria,
6224
patients.
In
relation
GBM
had
mean
33.36
(SD
58.00)
right
hemisphere
34.70
65.07)
left
hemisphere,
due
averages
hemispheres.
There
no
statistically
significant
differences,
p
=
0.35.
For
comparison
lobe
lobe,
there
23.23
40.03),
while
22.05
43.50),
GBM,
0.178.
Conclusions:
We
believe
that
before
treatment,
will
always
correct
know
where
how
behaves
clinically,
order
generate
conservative
or
surgical
treatment
guidelines
each
patient.
more
detailed
are
also
needed
show
why
associated
some
regions
than
others,
despite
structure
being
homologous
other
which
GMB
occurs
less
frequently,
knowing
its
predominant
very
important.
Brain Sciences,
Год журнала:
2023,
Номер
13(5), С. 817 - 817
Опубликована: Май 18, 2023
Diffuse
gliomas
are
the
most
common
type
of
primary
central
nervous
system
(CNS)
neoplasm
to
affect
adult
population.
The
diagnosis
diffuse
is
dependent
upon
integration
morphological
features
tumour
with
its
underlying
molecular
alterations,
and
integrative
has
become
increased
importance
in
fifth
edition
WHO
classification
CNS
neoplasms
(WHO
CNS5).
three
major
diagnostic
entities
as
follows:
(1)
astrocytoma,
IDH-mutant;
(2)
oligodendroglioma,
IDH-mutant
1p/19q-codeleted;
(3)
glioblastoma,
IDH-wildtype.
aim
this
review
summarize
pathophysiology,
pathology,
characteristics,
updates
encountered
CNS5
gliomas.
Finally,
application
implementing
necessary
tests
for
workup
these
pathology
laboratory
setting
discussed.
Cell Death and Disease,
Год журнала:
2024,
Номер
15(4)
Опубликована: Апрель 1, 2024
The
oncogenic
properties
of
members
belonging
to
the
forkhead
box
(FOX)
family
have
been
extensively
documented
in
different
types
cancers.
In
this
study,
our
objective
was
investigate
impact
FOXP3
on
glioblastoma
multiforme
(GBM)
cells.
By
conducting
a
screen
using
small
hairpin
RNA
(shRNA)
library,
we
discovered
significant
association
between
and
ferroptosis
GBM
Furthermore,
observed
elevated
levels
both
tissues
cell
lines,
which
correlated
with
poorer
prognosis.
found
promote
proliferation
cells
by
inhibiting
vitro
vivo.
Mechanistically,
not
only
directly
upregulated
transcription
GPX4,
but
also
attenuated
degradation
GPX4
mRNA
through
linc00857/miR-1290
axis,
thereby
suppressing
promoting
proliferation.
Additionally,
inhibitor
epirubicin
exhibited
ability
impede
induce
summary,
study
provided
evidences
that
facilitates
progression
via
linc00857/miR-1290/GPX4
highlighting
as
potential
therapeutic
target
for
GBM.
Journal of Clinical Medicine,
Год журнала:
2024,
Номер
13(12), С. 3460 - 3460
Опубликована: Июнь 13, 2024
Background:
Glioblastoma
is
a
primary
malignant
brain
tumor;
it
aggressive
with
high
degree
of
malignancy
and
unfavorable
prognosis
the
most
common
type
tumor.
Glioblastomas
can
be
located
in
brain,
cerebellum,
brainstem,
spinal
cord,
originating
from
glial
cells,
particularly
astrocytes.
Methods:
The
databases
MEDLINE,
Scopus,
Web
Science,
Google
Scholar,
CINAHL
were
researched
up
to
January
2024.
Two
authors
independently
performed
search,
study
selection,
data
extraction.
Methodological
quality
was
evaluated
an
assurance
tool
for
anatomical
studies
(AQUA).
statistical
mean,
standard
deviation,
difference
means
calculated
Student’s
t-test
presence
between
hemispheres
frontal
temporal
lobes
analyzed.
Results:
A
total
123
met
established
selection
criteria,
6224
patients.
In
relation
GBM
had
mean
33.36
(SD
58.00)
right
hemisphere
34.70
65.07)
left
hemisphere,
due
averages
hemispheres.
There
no
statistically
significant
differences,
p
=
0.35.
For
comparison
lobe
lobe,
there
23.23
40.03),
while
22.05
43.50),
GBM,
0.178.
Conclusions:
We
believe
that
before
treatment,
will
always
correct
know
where
how
behaves
clinically,
order
generate
conservative
or
surgical
treatment
guidelines
each
patient.
more
detailed
are
also
needed
show
why
associated
some
regions
than
others,
despite
structure
being
homologous
other
which
GMB
occurs
less
frequently,
knowing
its
predominant
very
important.
