Clinical Psychology Review, Год журнала: 2018, Номер 64, С. 99 - 109
Опубликована: Фев. 1, 2018
Язык: Английский
Developmental Psychobiology, Год журнала: 2020, Номер 63(2), С. 153 - 172
Опубликована: Март 29, 2020
Abstract Early‐life stress confers profound and lasting risk for developing cognitive, social, emotional, physical health problems. The effects of on the brain contribute to this risk, with frontolimbic circuitry particularly susceptible early experiences, possibly due its innervation glucocorticoid receptors timing circuit maturation. To date, majority studies have employed a categorical approach, comparing stress‐exposed versus non‐stress‐exposed youth. However, there is vast heterogeneity in nature exposure outcomes. Recent forays into understanding psychobiological dimensional approach focused experiential, environmental, temporal factors that influence association between subsequent vulnerability. This review highlights empirical findings inform circuitry. We identify timing, type, severity, controllability, predictability stress, degree which caregiver involved, as specific features may play substantial role differential propose framework these development partially determine how influences and, ultimately, mental health.
Язык: Английский
Процитировано
120
Current Opinion in Psychology, Год журнала: 2017, Номер 17, С. 1 - 6
Опубликована: Апрель 24, 2017
Язык: Английский
Процитировано
115
Developmental Cognitive Neuroscience, Год журнала: 2019, Номер 41, С. 100715 - 100715
Опубликована: Ноя. 12, 2019
In the past decade, there has been monumental progress in our understanding of neurobiological basis sensitive periods. Little is known, however, about evolution Recent studies have started to address this gap. Biologists built mathematical models exploring environmental conditions which periods are likely evolve. These investigate how mechanisms plasticity can respond optimally experience during an individual's lifetime. This paper discusses central tenets, insights, and predictions these models, relation empirical work on humans other animals. We also discuss future needed improve bridge between theory data, advancing their synergy. Our written accessible manner for a broad audience. hope will contribute recently emerging connections fields developmental neuroscience evolutionary biology.
Язык: Английский
Процитировано
96
American Journal of Psychiatry, Год журнала: 2021, Номер 178(11), С. 998 - 1013
Опубликована: Ноя. 1, 2021
Adversity early in life is common and a major risk factor for the onset of psychopathology. Delineating neurodevelopmental pathways by which adversity affects mental health critical identification targeted treatment approaches. A rapidly growing cross-species literature has facilitated advances identifying mechanisms linking with psychopathology, specific dimensions timing-related factors that differentially relate to outcomes, protective buffer against effects adversity. Yet, vast complexity heterogeneity environments trajectories contribute challenges understanding resilience context In this overview, author highlights progress four areas—mechanisms, heterogeneity, developmental timing, factors; synthesizes key challenges; provides recommendations future research can facilitate field. Translation across species ongoing refinement conceptual models have strong potential inform prevention intervention strategies reduce immense burden psychopathology associated
Язык: Английский
Процитировано
93
Current Directions in Psychological Science, Год журнала: 2021, Номер 30(5), С. 376 - 383
Опубликована: Авг. 6, 2021
Across species, caregivers exert a powerful influence on the neural and behavioral development of offspring. Increasingly, both animal human research has highlighted specific patterns in caregivers' behavior that may be especially important early life, as well neurobiological mechanisms linking caregiving experiences with long-term affective behavior. Here we delineate evidence for an sensitive period during infancy toddlerhood when caregiver inputs are predictable associated safety become biologically embedded via influences corticolimbic circuitry involved emotion regulation. We propose these signals prime to receptive later stage-specific influences, such external regulation children's emotional reactivity. Following adversity disrupts predictability this period, accelerated maturation foreshorten protracted plasticity is characteristic humans. This work implications prevention intervention efforts children exposed life adversity.
Язык: Английский
Процитировано
82
Developmental Science, Год журнала: 2020, Номер 24(1)
Опубликована: Май 16, 2020
Abstract A growing literature suggests that adversity is associated with later altered brain function, particularly within the corticolimbic system supports emotion processing and salience detection (e.g., amygdala, prefrontal cortex [PFC]). Although neighborhood socioeconomic disadvantage has been shown to predict maladaptive behavioral outcomes, for boys, most of research linking function focused on family‐level adversities. Moreover, although animal models studies normative development suggest there may be sensitive periods during which exerts stronger effects development, little prospective evidence exists in humans. Using two low‐income samples boys ( n = 167; 77), Census‐derived early childhood, but not adolescence, was uniquely greater PFC, reactivity ambiguous neutral faces adolescence young adulthood. These associations remained after accounting several adversities low family income, harsh parenting), highlighting independent developmentally specific neural context. Furthermore, both samples, indicators measuring income poverty status neighbors were predictive amygdala suggesting economic resources critical development.
Язык: Английский
Процитировано
79
Journal of Neuroscience, Год журнала: 2018, Номер 38(44), С. 9433 - 9445
Опубликована: Окт. 31, 2018
The ability to anticipate and respond appropriately the challenges opportunities present in our environments is critical for adaptive behavior. Recent methodological innovations have led substantial advances understanding of neurocircuitry supporting such motivated behavior adulthood. However, neural circuits cognitive processes that enable threat- reward-motivated undergo substantive changes over course development, these are less well understood. In this article, we highlight recent research human animal models demonstrating how developmental prefrontal-subcortical give rise corresponding processing threats rewards from infancy We discuss trajectories altered by experiential factors, as early-life stress, relevance onset treatment psychiatric disorders characterized dysregulation
Язык: Английский
Процитировано
76
Development and Psychopathology, Год журнала: 2018, Номер 31(02), С. 399 - 418
Опубликована: Апрель 1, 2018
Children reared in impoverished environments are at risk for enduring psychological and physical health problems. Mechanisms by which poverty affects development, however, remain unclear. To explore one potential mechanism of poverty's impact on social-emotional cognitive an experimental examination a rodent model scarcity-adversity was conducted compared to results from longitudinal study human infants families followed birth (N = 1,292) who faced high levels poverty-related scarcity-adversity. Cross-species supported the hypothesis that altered caregiving is pathway adversely impacts development. Rodent mothers assigned condition exhibited decreased sensitive parenting increased negative relative control condition. Furthermore, pups developmental competence as indicated disrupted nipple attachment, distress vocalization when contact with anesthetized mother, reduced preference maternal odor corresponding changes brain activation. Human inversely correlated positively parenting, fully mediated association infant indicators competence. Findings discussed perspective usefulness bidirectional-translational research inform interventions at-risk families.
Язык: Английский
Процитировано
61
Journal of the American Academy of Child & Adolescent Psychiatry, Год журнала: 2019, Номер 59(2), С. 274 - 282
Опубликована: Март 12, 2019
Язык: Английский
Процитировано
57
Developmental Psychobiology, Год журнала: 2021, Номер 63(6)
Опубликована: Июль 22, 2021
Children make up over half of the world's migrants and refugees face a multitude traumatic experiences prior to, during, following migration. Here, we focus on migrant children emigrating from Mexico Central America to United States review trauma related migration, as well its implications for mental health refugee children. We then draw upon early adversity literature highlight potential behavioral neurobiological sequalae migration-related exposure, focusing attachment, emotion regulation, fear learning extinction transdiagnostic mechanisms underlying development internalizing externalizing symptomatology early-life adversity. This underscores need interdisciplinary efforts both mitigate effects faced by youth and, primary importance, prevent child exposure in context Thus, conclude outlining policy recommendations aimed at improving youth.
Язык: Английский
Процитировано
45