Prognostic significance of total metabolic tumor volume on baseline 18F-FDG PET/CT in patients with lung adenocarcinoma: further stratification of the ninth edition of TNM staging subgroups
Nuclear Medicine Communications,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 14, 2025
Background
This
study
aimed
to
investigate
the
prognostic
value
of
baseline
total
metabolic
tumor
volume
(TMTV)
on
18
F-fluorodeoxyglucose
positron
emission
tomography/computed
tomography
and
its
potential
for
further
stratification
within
ninth
tumor-node-metastasis
(TNM)
staging
system
in
patients
with
lung
adenocarcinoma
(LUAD).
Methods
A
cohort
384
LUAD
who
had
undergone
pretreatment
PET/CT
were
included
this
retrospective
study.
The
optimal
cutoff
TMTV
was
determined
through
analysis
time-dependent
receiver
operating
characteristic
curves.
overall
survival
(OS)
conducted
utilizing
Kaplan–Meier
Predictive
capacity
evaluated
using
C
statistic.
Results
40.13
ml.
rates
varied
significantly
across
stages
I
(
n
=
164),
II
37),
III
46),
IV
137);
however,
there
no
statistically
significant
difference
between
P
0.440).
In
II–IV,
2-year
OS
less
than
ml
higher
at
81.7
86.7%,
respectively,
compared
greater
equal
only
56.5
42.5%.
No
stage
presented
or
ml,
rate
98.3%.
index
did
not
reveal
a
TNM
their
predictive
ability
(0.83
vs.
0.85,
0.159).
Conclusion
demonstrates
robust
utility
LUAD,
while
incorporation
may
offer
additional
risk
distinct
stages.
Язык: Английский
Caucasian validation of downstaging from IIB to IIA in T1N1M0 patients within the 9th edition of the non‐small cell lung cancer tumor‐node‐metastasis staging
Cancer Medicine,
Год журнала:
2024,
Номер
13(14)
Опубликована: Июль 1, 2024
Abstract
Background
The
9th
edition
of
the
lung
cancer
tumor‐node‐metastasis
(TNM)
staging
introduced
adjustments,
including
reclassification
T1N1M0
patients
from
stage
IIB
to
IIA.
This
update
used
data
mostly
Asian
populations.
However,
applicability
these
adjustments
Caucasian
remains
uncertain.
Methods
Stage
II
non‐small
cell
(NSCLC)
Surveillance,
Epidemiology,
and
End
Results
(SEER)
database
were
included.
Kaplan–Meier
analysis
with
log‐rank
testing
compared
overall
survival
(OS)
cancer‐specific
(CSS).
Propensity
score
matching
(PSM)
balanced
baseline
characteristics.
least
absolute
shrinkage
selection
operator
(LASSO)‐based
Cox
analyses
identified
prognostic
factors.
Among
10,470
eligible
NSCLC
(median
age:
69
years;
male:
53.1%),
there
2736
in
IIA,
2112
IIA
New,
5622
groups.
Before
PSM,
outcomes
New
similar
those
but
better
than
IIB.
After
showed
rates
(OS,
p
=
0.276;
CSS,
0.565).
Conversely,
had
worse
<
0.001;
0.005).
LASSO‐based
confirmed
inferior
prognosis
(OS
HR:
1
vs.
1.325,
CSS
1.327,
0.001).
Conclusions
downstaging
TNM
unverified
Caucasians.
Caution
is
warranted
assessing
individuals.
Further
validation
our
findings
necessary.
Язык: Английский