Cyclodextrin-Based Chemically Modified pH-Responsive New Kind of Aldehyde-Functionalized Nanosponge Nanoparticles for Doxorubicin Hydrochloride Delivery

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106853 - 106853

Опубликована: Март 1, 2025

Язык: Английский

Enhancing chemotherapeutic efficacy: Niosome‐encapsulated Dox‐Cis with MUC‐1 aptamer

Cancer Medicine, Год журнала: 2024, Номер 13(15)

Опубликована: Авг. 1, 2024

Abstract Background Cancer remains a formidable global health challenge, currently affecting nearly 20 million individuals worldwide. Due to the absence of universally effective treatments, ongoing research explores diverse strategies combat this disease. Recent efforts have concentrated on developing combined drug regimens and targeted therapeutic approaches. Objective This study aimed investigate anticancer efficacy conjugated system, consisting doxorubicin cisplatin (Dox‐Cis), encapsulated within niosomes modified with MUC‐1 aptamers enhance biocompatibility target specific cancer cells. Methods The chemical structure Dox‐Cis conjugate was characterized using Fourier Transform Infrared Spectroscopy (FTIR) Liquid Chromatography Quadrupole Time‐of‐Flight Mass Spectrometry (LC‐Q‐TOF/MS). zeta potential morphological parameters niosomal vesicles were determined through Dynamic Light Scattering (DLS) Transmission Electron Microscopy (TEM). In vitro assessments cell viability apoptosis conducted positive HeLa cells negative U87 Results findings confirmed successful conjugation Dox Cis niosomes. Nio/Dox‐Cis/MUC‐1 formulation demonstrated enhanced compared individual drugs their unencapsulated combination in both lines. Notably, exhibited greater effectiveness (38.503 ± 1.407) than (46.653 1.297). Conclusion underscores as promising strategy for treatment, particularly platforms that facilitate delivery approach could lead more personalized therapies.

Язык: Английский

Engineered Niosomes for Cancer Therapy: Classification, Synthesis, and Clinical Applications

BioNanoScience, Год журнала: 2024, Номер 15(1)

Опубликована: Дек. 2, 2024

Язык: Английский