Molecules,
Год журнала:
2023,
Номер
28(12), С. 4676 - 4676
Опубликована: Июнь 9, 2023
The
largely
uncharted
complexation
chemistry
of
the
veterinary
polyether
ionophores,
monensic
and
salinomycinic
acids
(HL)
with
metal
ions
type
M4+
known
antiproliferative
potential
antibiotics
has
provoked
our
interest
in
exploring
coordination
processes
between
MonH/SalH
Ce4+.
(1)
Methods:
Novel
monensinate
salinomycinate
cerium(IV)-based
complexes
were
synthesized
structurally
characterized
by
elemental
analysis,
a
plethora
physicochemical
methods,
density
functional
theory,
molecular
dynamics,
biological
assays.
(2)
Results:
formation
species
general
composition
[CeL2(OH)2]
[CeL(NO3)2(OH)],
depending
on
reaction
conditions,
was
proven
both
experimentally
theoretically.
metal(IV)
[CeL(NO3)2(OH)]
possess
promising
cytotoxic
activity
against
human
tumor
uterine
cervix
(HeLa)
cell
line,
being
highly
selective
(non-tumor
embryo
Lep-3
vs.
HeLa)
compared
to
cisplatin,
oxaliplatin,
epirubicin.
Cancers,
Год журнала:
2025,
Номер
17(2), С. 195 - 195
Опубликована: Янв. 9, 2025
Breast
cancer
(BC)
remains
one
of
the
most
prevalent
and
deadly
cancers
worldwide,
with
limited
access
to
advanced
treatments
in
developing
regions.
There
is
a
critical
need
for
novel
therapies
unique
mechanisms
action,
especially
overcome
resistance
conventional
platinum-based
drugs.
This
study
investigates
anticancer
potential
ruthenium
complex
Bis(quinolin-8-olato)bis(triphenylphosphine)ruthenium(II)
(Ru(quin)2)
ER-positive
(T47D)
triple-negative
(MDA-MB-231)
BC
cell
lines.
Ru(quin)2
demonstrated
dose-dependent
cytotoxicity,
IC50
values
48.3
μM
T47D
cells
45.5
MDA-MB-231
cells.
Its
cytotoxic
effects
are
primarily
driven
by
apoptosis,
as
shown
increased
BAX
expression,
enhanced
caspase-3
activity,
reduced
Aurora
B
kinase
levels,
elevated
histone
release.
also
induced
autophagy,
evidenced
LC3-I
LC3-II
conversion
SQSTM1,
partially
mediated
through
MAPK
signaling.
Furthermore,
G0/G1
cycle
arrest
downregulating
cyclin
D1,
CDK4,
CDK6,
alongside
upregulation
CDK
inhibitor
p21.
emerges
potent
candidate
treatment,
multiple
action
involving
arrest.
Further
studies
warranted
elucidate
its
detailed
molecular
evaluate
therapeutic
vivo,
moving
toward
clinical
applications
both
management.
Dalton Transactions,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
The
use
of
bismuth
and
its
compounds
in
biomedicine
has
developed
rapidly
recent
years.
Due
to
their
unique
properties,
there
are
great
opportunities
for
the
development
new
non-invasive
strategies
early
diagnosis
effective
treatment
cancers.
This
perspective
highlights
key
fabrication
methods
generate
well-defined
clinically
relevant
materials
varying
characteristics.
On
one
hand,
this
opens
up
a
wide
range
possibilities
unimodal
multimodal
imaging.
other
strategies,
which
increasingly
based
on
combinatorial
therapies,
given
deal
attention.
One
biggest
challenges
remains
selective
tumour
targeting,
whether
active
or
passive.
Here
we
present
an
overview
developments
moving
forward
from
simple
enrichment
at
site
via
uptake
by
mononuclear
phagocytic
system
(MPS)
more
specific
targeting
covalent
modification
with
tumour-seeking
molecules
either
small
antibody-derived
molecules.
Dalton Transactions,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
New
Ru(
ii
)
and
Cu(
complexes
with
polyamine
ligands
show
high
cytotoxicity
against
prostate
cancer
cells,
inhibit
adhesion/migration,
reduce
ROS,
offering
promising,
selective,
less
toxic
alternatives
to
cisplatin.
