Science Progress, Год журнала: 2024, Номер 107(4)
Опубликована: Окт. 1, 2024
The incidence of cancer is increasing and evolving as a major source mortality. Nanotechnology has garnered considerable scientific interest in recent decades can offer promising solution to the challenges encountered with traditional chemotherapy. Nanoparticle utilization holds promise combating other diseases, offering exciting prospects for drug delivery systems medicinal applications. Metallic nanoparticles exhibit remarkable physical chemical properties, such their minute size, composition, structure, extensive surface area, rendering them versatile cost-effective. Research demonstrated significant beneficial impact on treatment, characterized by enhanced targeting abilities, gene activity suppression, improved efficiency. By incorporating ligands, functionalized metal ensure precise energy deposition within tumors, thereby augmenting treatment accuracy. Moreover, beyond therapeutic efficacy, serve valuable tools cell visualization, contributing diagnostic techniques. Utilizing allows simultaneous diagnosis while also facilitating controlled release, thus revolutionizing care. This narrative review investigates advancements types mechanisms cells, application clinical scenarios, potential toxicity medicine.
Язык: Английский
Процитировано
11Hyaluronic Acid – Coated Niosomes for Curcumin Targeted Delivery into Breast Cancer Cells
ChemistrySelect, Год журнала: 2024, Номер 9(3)
Опубликована: Янв. 17, 2024
Abstract This study described a hyaluronic acid (HA) coated niosomes (Nio) encapsulated curcumin (CRM) (CRM‐HA‐Nio) to improve therapeutic properties via targeted delivery. CRM‐HA‐Nio was prepared by thin film hydration method and characterized dynamic light scattering transmission electron microscopy. Release assay performed utilizing dialysis method. Antioxidant, Cell viability, cellular uptake assays were evaluate the biological activity. has 142.93±39.71 nm size with −20.67±1.10 charge showed good stability 93±4.35 % encapsulation efficiency displayed pH‐independent release pattern. 2‐fold antioxidant improvement compared free CRM. much better cytotoxic activity on MCF‐7 cell line IC 50 of 1.851±0.45 μM CRM equal 5.230±0.85 μM, approximately 3‐fold enhancement. may be promising nanocarrier elucidate bioactivity against cancer when oxidative stress is major side effect.
Язык: Английский
Процитировано
9Advancements in nanotechnology for the delivery of phytochemicals
Journal of Integrative Medicine, Год журнала: 2024, Номер 22(4), С. 385 - 398
Опубликована: Апрель 24, 2024
Язык: Английский
Процитировано
8Encapsulation of gingerol into nanoliposomes: Evaluation of in vitro anti‐inflammatory and anti‐cancer activity
Biomedical Chromatography, Год журнала: 2024, Номер 38(8)
Опубликована: Май 26, 2024
Abstract Nanoliposomes (NLs) are ideal carriers for delivering complex molecules and phytochemical products, but ginger by‐products, despite their therapeutic benefits, have poor bioavailability due to low water solubility stability. Crude extracts (CGEs) 6‐gingerol were individually encapsulated within NLs in vitro activity assessment. In evaluation of anti‐proliferative anti‐inflammatory properties CGE was performed on healthy human periodontal ligament (PDL) fibroblasts MDA‐MB‐231 breast cancer cells. Encapsulation efficiency loading capacity reached 25.23% 2.5%, respectively. found stable up 30 days at 4°C with a gradual load loss 20%. cytotoxic effect exceeded 70% the cell line, comparable manner non‐encapsulated CGE. The an IC 50 3.11 ± 0.39, 7.14 0.80, 0.82 0.55 μM inhibiting IL‐8 evident, indicating its potential activity. Encapsulating enhanced stability facilitated biological All compounds, including vitamin C, equivalent concentrations below 2 mg/mL, slight difference antioxidant capable 50% 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) substrate comparable.
Язык: Английский
Процитировано
8Dual-loaded liposomal carriers to combat chemotherapeutic resistance in breast cancer
Expert Opinion on Drug Delivery, Год журнала: 2024, Номер 21(2), С. 309 - 324
Опубликована: Янв. 29, 2024
The resistance to chemotherapy is a significant hurdle in breast cancer treatment, prompting the exploration of innovative strategies. This review discusses potential dual-loaded liposomal carriers combat chemoresistance and improve outcomes for patients.
Язык: Английский
Процитировано
7The role of quercetin in NLRP3-associated inflammation
Inflammopharmacology, Год журнала: 2024, Номер unknown
Опубликована: Сен. 22, 2024
Язык: Английский
Процитировано
7Preparation, Characterization, and Anticancer Activity of PEGylated Nano Liposomal Loaded with Rutin against Human Carcinoma Cells (HT‐29)
Chemistry & Biodiversity, Год журнала: 2023, Номер 20(11)
Опубликована: Окт. 2, 2023
The abstract discusses the development of rutin-loaded nanoliposomes and their anti-colorectal cancer activity against human carcinoma cells (HT-29). study characterizes using thin-film hydration method analyzes size, charge, polydispersity index. encapsulation efficiency drug loading ability rutin at different concentrations were investigated. found to be stable for up one month 4 °C showed sustained release 24 h. anti-cancer was concentration-dependent significantly improved compared free rutin. PEGylated with (1.8 mg/ml) highest ability, along selectivity cells. Overall, provides important insights into potential use treatment colorectal cancer.
Язык: Английский
Процитировано
16Oleuropein impact on colorectal cancer
Future Science OA, Год журнала: 2024, Номер 10(1)
Опубликована: Янв. 5, 2024
Colorectal cancer (CRC) is considered the third most common in world. In Mediterranean region, olives and olive oil play a substantial role diet medical traditional behaviors. They totally believe that high consumption of products can treat wide range diseases decrease risk illness. Oleuropein main active antioxidant molecule found pre-mature fruit leaves. Recently, it has been demonstrated oleuropein used therapy as an anti-proliferative apoptotic agent for some cells. this review, we would like to explore conclusive effects on CRC with respect vitro vivo studies.
Язык: Английский
Процитировано
3Meta-analysis of nano-phytosomes: unleashing the potential of plant-derived compounds for advancing cancer therapy
Natural Product Research, Год журнала: 2024, Номер unknown, С. 1 - 20
Опубликована: Апрель 26, 2024
Nano-phytosomes are considered as an efficient drug delivery system for phytochemicals. Phytosomes enhance stability and significantly improves phytochemicals bioavailability therapeutic efficacy. Thorough meta-analysis of 93 articles, phytochemical versus phytosomes size, charge, polydispersity index (PDI) IC
Язык: Английский
Процитировано
3Innovative liposomal coumarin: A promising solution for enhancing soft white cheese quality
PLoS ONE, Год журнала: 2025, Номер 20(3), С. e0315771 - e0315771
Опубликована: Март 18, 2025
Background Coumarin is a natural bioactive compound found in many plants and acquires antibacterial, antioxidant anticoagulant activities. The antibacterial activity of coumarin has never been tested after being encapsulated liposomes. This study was carried out to screen the main functional components Rubus canescens DC crude extract (CE), develop nanoliposome, test its anti-bacterial properties. Methods R. CE screened for compounds using liquid chromatography-mass spectrometry (LC-MS). Pure commercial loaded into liposomes characterized terms surface morphology, hydrodynamic diameter, zeta potential, encapsulation efficiency (EE). evaluated against ascorbic acid. both alone liposome-encapsulated Staphylococcus aureus , Salmonella typhimurium Pseudomonas aeruginosa inoculated soft white cheese (SWC) also evaluated. Results predominant constituent CE, coumarin. Comparing DPPH scavenging that acid, exhibited an insignificant effect (p ≥ 0.05). minimum inhibitory concentration (MIC) values P. E. coli Staph. S. L. monocytogenes were 2.5, 1.25, 1.25 µg/ml, respectively. bactericidal (MBC) these microorganisms 5, 2.5 successfully nanoliposomes, which had polydispersity index (PDI) 0.36 ± 0.35 Đ, diameter 127.8 0.3 nm, zeta-potential -61.03 2.9 mV, EE 40.93 0.2%. Both liposome with showed effects bacterial strains SWC over 30-day storage period at 4 ° C. Conclusions formulated .
Язык: Английский
Процитировано
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