Neuroprotective effects of dendrobium endophytes metabolites in SH-SY5Y cells via the Nrf2/Keap1 pathway DOI Creative Commons
Yan Liang, Jia Liu,

Lu qi Qin

и другие.

Heliyon, Год журнала: 2024, Номер 10(6), С. e28222 - e28222

Опубликована: Март 1, 2024

Recent studies have revealed that endophytes in plants can produce metabolites with activity is comparable to or identical the host. Dendrobine has attracted much attention field of neurodegenerative diseases by exhibiting anti-oxidative stress and neuroprotective effects. This study aimed investigate protective effects mechanisms dendrobium Pseudomonas protegens CM-YJ44 Priestia megaterium D-HT207 against H2O2-induced oxidative injury SH-SY5Y cells. Results showed there were 50 compounds 72 D-HT207. Those both increased significantly cell viability, decreased contents ROS It was confirmed inhibited cells, which mechanism related inhibition production, alteration MMP, apoptosis inflammatory factors expression via Nrf2/Keap1 pathway.

Язык: Английский

Unveiling the potential of dendrobine: insights into bioproduction, bioactivities, safety, circular economy, and future prospects DOI
Surendra Sarsaiya, Archana Jain,

Fuxing Shu

и другие.

Critical Reviews in Biotechnology, Год журнала: 2025, Номер unknown, С. 1 - 19

Опубликована: Янв. 6, 2025

This comprehensive review aims to explore and consolidate the current knowledge on dendrobine, including its biological activities, molecular mechanisms of action, effects various physiological processes, potential toxicity, safety considerations, in order unlock full applications. Dendrobine has diverse effects, anti-inflammatory, antioxidant, neuroprotective, immunomodulatory, anticancer effects. also exerts neuroprotective by boosting neuronal survival, reducing neuroinflammation, regulating neurotransmitter release. immunomodulatory that control immune cell function modify immunological responses. exhibits properties decreasing tumor angiogenesis metastasis, causing apoptosis cancer cells, inhibiting growth. discusses idea a circular economy produce researching cutting-edge sustainable methods maximize resource efficiency reduce environmental Additionally, supporting principles for production outlining future study areas, this discovery will help use dendrobine variety applications while preserving environment. Future research should focus advancing application personalized medicine, exploring green bioproduction methods, ensuring ethical sourcing practices. An enhanced understanding synergistic therapies could revolutionize healthcare, whereas conservation efforts safeguard ecological impact.

Язык: Английский

Процитировано

1

Erianin isolated from Dendrobium huoshanense alleviated neuroinflammation in MPTP-induced Parkinson's disease model via NF-κB/NLRP3 pathway DOI
Connie Yan, Z. Ryan Tian,

Weiquan Ruan

и другие.

Journal of Ethnopharmacology, Год журнала: 2025, Номер unknown, С. 119620 - 119620

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0

Neuroprotective effects of dendrobium endophytes metabolites in SH-SY5Y cells via the Nrf2/Keap1 pathway DOI Creative Commons
Yan Liang, Jia Liu,

Lu qi Qin

и другие.

Heliyon, Год журнала: 2024, Номер 10(6), С. e28222 - e28222

Опубликована: Март 1, 2024

Recent studies have revealed that endophytes in plants can produce metabolites with activity is comparable to or identical the host. Dendrobine has attracted much attention field of neurodegenerative diseases by exhibiting anti-oxidative stress and neuroprotective effects. This study aimed investigate protective effects mechanisms dendrobium Pseudomonas protegens CM-YJ44 Priestia megaterium D-HT207 against H2O2-induced oxidative injury SH-SY5Y cells. Results showed there were 50 compounds 72 D-HT207. Those both increased significantly cell viability, decreased contents ROS It was confirmed inhibited cells, which mechanism related inhibition production, alteration MMP, apoptosis inflammatory factors expression via Nrf2/Keap1 pathway.

Язык: Английский

Процитировано

1