Mixture of Rhodiola rosea and Nelumbo nucifera Extracts Ameliorates Sleep Quality of Adults with Sleep Disturbance

Nutrients, Год журнала: 2024, Номер 16(12), С. 1867 - 1867

Опубликована: Июнь 14, 2024

Chronic sleep disturbance affects daily functioning, leading to decreased concentration, fatigue, and higher healthcare costs. Traditional insomnia medications are often associated with adverse side effects. This study investigated the efficacy of a novel compound derived from Rhodiola rosea Nelumbo nucifera extracts (named RNE) in improving quality fewer The included individuals between ages 20 65 subthreshold evaluated effects RNE on sleep, life. Participants took 750 mg at bed-time for two weeks. used Insomnia Severity Index (ISI), Pittsburgh Sleep Quality (PSQI), diary, Fatigue Scale (FSS), Short Form 36 Health Survey (SF-36) assessments. Of participants, 13 completed showed significant improvements quality. results ISI PSQI scores, 57% reduction wake-time after onset, improved efficiency. Although FSS scores remained unchanged, were seen SF-36 physical mental health scores. suggest that is an effective, low-risk option disturbance, significantly overall wellbeing without

Язык: Английский

In silico identification of novel ligands targeting stress-related human FKBP5 protein in mental disorders

PLoS ONE, Год журнала: 2025, Номер 20(3), С. e0320017 - e0320017

Опубликована: Март 17, 2025

FK506-binding protein 51 (FKBP51 or FKBP5) serves as a crucial stress modulator implicated in mental disorders, presenting potential target for intervention. Inhibitors like SAFit2, rapamycin, and tacrolimus exhibit promising interactions with this protein. Despite these advances, challenges persist diversifying FKBP5 ligands, prompting further exploration of interaction partners. Hence, study aims to identify other ligands. Employing molecular docking, we generated complexes various ligands (rapamycin, tacrolimus, SAFit2-Selective antagonist FKBP51 by induced fit, ascomycin, pimecrolimus, rosavin, salidroside, curcumin, apigenin, uvaricin, ruscogenin, neoruscogenin, pumicalagin, castalagin, grandinin). We identified the top 3 best which ruscogenin neoruscogenin had notable abilities cross blood-brain barrier have high gastrointestinal absorption, curcumin. Toxicity predictions show be least toxic based on oral toxicity classification (Class VI). Tyrosine (Tyr113) formed consistent all complex, reinforcing their involvement modulation. Molecular dynamic (MD) simulation validated strong between our three key provided an understanding stability complex. The binding free energy (ΔG) (based pharmacological properties) from MD analysis is -31.78 kcal/mol -30.41 -27.6 These molecules, therefore, can serve therapeutic molecules biomarkers research stress-impacted disorders. While offering implications disorders attenuating impact, it emphasize that ligands’ transition clinical applications necessitates extensive experimental research, including trials, unravel intricate neural pathways involved interactions.

Язык: Английский

(±) Citronellal Exerts Antidepressant and Modulatory Effects on Duloxetine Possibly Through Serotonin and Norepinephrine Reuptake Interaction Pathway: In Vivo Approach with Molecular Docking

ChemistrySelect, Год журнала: 2024, Номер 9(46)

Опубликована: Дек. 1, 2024

Abstract This study aims to assess the antidepressant and modulatory activities of citronellal (CIT) on duloxetine (DUX) its possible underlying mechanisms through in vivo silico studies. Hence, forced swimming test (FST), tail suspension (TST), open field (OFT) were carried out. Mice treated with different doses CIT (50, 100, 200 mg/kg, p.o.), while DUX (15 p.o.) was used as a positive control vehicle served negative control. Additionally, molecular docking conducted evaluate binding interactions. Results demonstrated that dose‐dependently significantly ( p < 0.05) alleviated immobility time both FST TST. At dose showed notable effects times 42.17 ± 3.70 70.17 2.56 s TST, respectively. In combination therapy, (100 mg/kg) modulated activity DUX. However, is confirmed by OFT test, which reduced locomotion activity. Further, exhibited moderate affinity (−6.1 kcal/mol) toward serotonin norepinephrine reuptake transporters (SRT NRT) forming several bonds. conclusion, activity, possibly interacting SRT NRT.

Язык: Английский