Design, theoretical approaches and new framework of pyrazolo[3,4-d]pyrimidine as potent anticancer agents: Efficient synthesis, ADME-T and molecular docking

Results in Chemistry, Год журнала: 2025, Номер 14, С. 102093 - 102093

Опубликована: Фев. 1, 2025

Язык: Английский

---

Design, Synthesis of 3‐(Aryl)‐1‐(2‐p‐tolylthiazol‐4‐yl)prop‐2‐en‐1‐ones as Alpha(α)‐Amylase Inhibitors

Chemistry & Biodiversity, Год журнала: 2024, Номер 21(9)

Опубликована: Июль 2, 2024

α-Amylase inhibition is vital in controlling diabetic complications. Herein, we have synthesized a hybrid scaffold based on thiazole-chalcone to access α-amylase inhbition. The proposed structures were verified with spectroscopic techniques (UV-Vis., FT-IR,

Язык: Английский

---

New Tetrazole-Annulated Pyrazolyl–Pyrimidine Derivatives as Antimycobacterial Targets: Design, Synthesis, Molecular Docking, and ADME Profiling

Russian Journal of General Chemistry, Год журнала: 2024, Номер 94(8), С. 2008 - 2017

Опубликована: Авг. 1, 2024

Язык: Английский

---

Natural Products‐Based Anticancer Agents: Synthesis and Anticancer Activities of Funtumine Amide/sulfonamide Derivatives

Chemistry & Biodiversity, Год журнала: 2024, Номер unknown

Опубликована: Окт. 9, 2024

Abstract Funtumine is a pregnene‐type steroidal alkaloid exhibiting moderate anticancer activity. To discover novel natural product‐based drugs, series of funtumine amide/sulfonamide derivatives were papered and identified using spectroscopic techniques. Additionally, the structures compounds 2j , 3a 4k further confirmed through X‐ray diffraction analysis. Biological activity experiments conducted against three cancer cell lines revealed that several synthesized demonstrated inhibition activities comparable to or exceeding those commercial agent, 5‐Fluorouracil. Especially compound 4i notably strong growth inhibitory effect on HePG2 (IC 50 =14.89 μ M) HCT116 =15.67 lines, while minimal cytotoxicity towards human normal BEAS‐2B cells. Preliminary structure‐activity relationships (SARs) analysis indicated conversion carbonyl group at C‐20 position hydroxyl could yield more potent compounds.

Язык: Английский

---

Synthesis of 1,2,3-triazole-linked silanes and exploration of their anti-bacterial potential via in-silico and in-vitro approach

Inorganica Chimica Acta, Год журнала: 2024, Номер 577, С. 122490 - 122490

Опубликована: Дек. 9, 2024

Язык: Английский

---

Design, synthesis, in vitro and in silico studies of 1,2,3-triazole incorporated tetrazoles as potent antitubercular agents

Journal of Molecular Structure, Год журнала: 2024, Номер 1327, С. 141242 - 141242

Опубликована: Дек. 27, 2024

Язык: Английский

---