Seseli foliosum (Somm. et Levier) Manden.—A Comprehensive Phytochemical and Biological Evaluation
Molecules,
Год журнала:
2025,
Номер
30(3), С. 725 - 725
Опубликована: Фев. 5, 2025
The
genus
Seseli
L.
(Apiaceae
family)
is
widespread
across
Europe
and
Asia,
with
ten
species
identified
in
Georgia.
Among
these,
foliosum
(Somm.
et
Levier)
Manden.,
notable
for
its
unique
pharmacological
properties.
To
our
knowledge,
comprehensive
phytochemical
biological
investigations
have
not
yet
been
conducted.
primary
aim
of
this
research
to
explore
the
chemical
properties
S.
foliosum,
thereby
enhancing
potential
applications
medicine
related
fields.
Different
chromatographic
techniques
were
utilized
isolate
individual
compounds
identify
composition
MeOH
Et2O
extracts
from
seeds
roots.
A
battery
assays
(antimicrobial,
antioxidant,
enzymatic,
anxiolytic,
cytotoxic)
employed
assess
extracts.
results
gas
chromatography
mass
spectrometry
(GC/MS)
revealed
that
both
contain
a
diverse
array
compounds,
including
monoterpenoids,
sesquiterpenoids,
phenolic
compounds.
Furanocoumarin
edultin
was
isolated
extract
by
liquid–liquid
separation
(LLS).
exhibited
important
enzyme
inhibitory,
antimicrobial
activities
efficacy
against
Staphylococcus
aureus
(MIC
125
µg/mL)
Candida
glabrata
62.5
µg/mL).
Underground
showed
advanced
cytotoxic
activity,
particularly
hypopharyngeal
carcinoma
cells
(CC50
22.33
µg/mL
27.16
µg/mL,
respectively).
study
provides
wide-range
analysis
highlighting
as
source
bioactive
These
findings
contribute
understanding
therapeutic
lay
groundwork
further
clinical
research.
Язык: Английский
1,8-Cineole Alleviates Hippocampal Oxidative Stress in CUMS Mice via the PI3K/Akt/Nrf2 Pathway
Nutrients,
Год журнала:
2025,
Номер
17(6), С. 1027 - 1027
Опубликована: Март 14, 2025
Background:
This
study
investigates
the
neuroprotective
effects
of
1,8-cineole
(1,8-CH),
against
hippocampal
oxidative
stress
in
a
chronic
unpredictable
mild
(CUMS)
mice
model
depression,
focusing
on
underlying
molecular
mechanisms.
Methods:
The
CUMS
exposure
were
assessed
by
measuring
markers,
antioxidant
activity,
and
neuronal
damage
hippocampus
using
histopathology,
network
pharmacology,
Western
blot
analysis,
small
interfering
RNA
(siRNA)
knockdown
experiments.
Results:
1,8-CH
significantly
alleviated
depression-like
behaviors
mice.
induced
hippocampus,
evidenced
elevated
MDA
levels,
decreased
damage.
DHE
staining
revealed
ROS
accumulation.
Treatment
with
reducing
MDA,
restoring
lowering
while
improving
structure.
Network
pharmacology
identified
PI3K/Akt/Nrf2
pathway
as
key
mediator
1,8-CH’s
neuroprotection,
which
was
supported
results,
demonstrating
PI3K/Akt
activation
potential
enhancement
Nrf2
nuclear
translocation.
Furthermore,
corticosterone-induced
PC12
cells,
abolished
inhibition
siRNA
knockdown,
confirming
Nrf2’s
role.
Conclusions:
These
findings
suggest
that
alleviates
CUMS-induced
depression
via
pathway,
highlighting
its
health
supplement
for
managing
depression.
Язык: Английский