Design, molecular docking and biological study of novel phenoxyquinoline bearing pyrazole scaffolds as potent anticancer agents

Journal of Molecular Structure, Год журнала: 2025, Номер unknown, С. 142213 - 142213

Опубликована: Март 1, 2025

Язык: Английский

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Design, Synthesis and Characterization of New Fused Pyrazole Systems: In Vitro Anti-bacterial, Anti-fungal, Antioxidant Evaluation, In Silico DFT and Molecular Docking Studies

Journal of Molecular Structure, Год журнала: 2025, Номер unknown, С. 142163 - 142163

Опубликована: Март 1, 2025

Язык: Английский

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Implication of protein post translational modifications in gastric cancer

Frontiers in Cell and Developmental Biology, Год журнала: 2025, Номер 13

Опубликована: Фев. 4, 2025

Gastric cancer (GC) is one of the most common and highly lethal malignant tumors worldwide, its occurrence development are regulated by multiple molecular mechanisms. Post-translational modifications (PTM) forms include ubiquitylation, phosphorylation, acetylation methylation. Emerging research has highlighted lactylation glycosylation. The diverse realm PTM crosstalk linked to many critical signaling events involved in neoplastic transformation, carcinogenesis metastasis. This review provides a comprehensive overview impact on progression GC. Specifically, aberrant have been shown alter proliferation, migration, invasion capabilities GC cells. Moreover, closely associated with resistance chemotherapeutic agents Notably, this also discusses phenomenon crosstalk, highlighting interactions among their roles regulating pathways protein functions. Therefore, in-depth investigation into mechanisms targeted therapeutic strategies hold promise for advancing early diagnosis, treatment, prognostic evaluation GC, offering novel insights future directions.

Язык: Английский

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3,5-Disubstituted pyrazoline as a promising core for anticancer agents: mechanisms of action and therapeutic potentials

Future Medicinal Chemistry, Год журнала: 2025, Номер unknown, С. 1 - 21

Опубликована: Март 13, 2025

The rapidly growing interest in the literature about anticancer activity of 3,5-disubstituted pyrazolines and their promising therapeutic potentials/pharmacological properties, supported by number pyrazoline derivatives currently clinical use or trials, encouraged us to review vitro antiproliferative effects biochemical investigations probable mechanisms action. Nevertheless, many reported pyrazoline-bearing compounds have without an explored mode action, which opens new research avenues examine profiles further. Therefore, is a core that can be used design with based on structure-activity relationship summarized this obtain higher potency selectivity.

Язык: Английский

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Pyrazol-3-yldiazonium Salts as Key Reagents for C–C Bond Formation and Pyrazole-Containing Heterocycle Synthesis

Synthesis, Год журнала: 2025, Номер unknown

Опубликована: Май 20, 2025

Abstract A novel application of 1-methylpyrazol-3-yldiazonium salts in the Meerwein reaction was introduced. These diazonium reacted with α,β-unsaturated functionalized compounds under conditions to yield pyrazole-containing building blocks, which subsequently allowed cyclization reactions bisnucleophiles for synthesis pyrazol-3-yl-containing heterocyclic systems. In this way, 2-aminothiazole, 2-aminoselenazole, thiazolidin-4-one, selenazolidin-4-one, 3-hydroxythiophene, and 3-aminothiophene rings were efficiently prepared.

Язык: Английский

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A comprehensive review on synthetic strategy and MOA of marketed drugs having therapeutically potential chemical entity pyrazole

Journal of the Iranian Chemical Society, Год журнала: 2024, Номер unknown

Опубликована: Сен. 17, 2024

Язык: Английский

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