Expression level of miR-548aa in tissue samples of patients with colorectal cancer

Molecular Biology Reports, Год журнала: 2025, Номер 52(1)

Опубликована: Янв. 16, 2025

Язык: Английский

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Robotic-assisted colorectal surgery in colorectal cancer management: a narrative review of clinical efficacy and multidisciplinary integration

Frontiers in Oncology, Год журнала: 2025, Номер 15

Опубликована: Апрель 7, 2025

Colorectal cancer (CRC) remains a formidable global health challenge, ranking among the most prevalent malignancies and principal contributor to cancer-associated mortality. While traditional open surgery has historically been cornerstone of CRC treatment, advent minimally invasive techniques, particularly robotic-assisted colorectal (RACS), garnered significant momentum owing technological advancements in field. Robotic platforms, exemplified by da Vinci Surgical System, offer superior three-dimensional visualization, enhanced dexterity, heightened precision, yielding improved perioperative outcomes, anatomically intricate regions such as pelvis. This review provides critical appraisal current landscape RACS, emphasizing its superiority over conventional laparoscopic approaches. The increased control precision afforded robotic have shown optimize outcomes complex procedures total mesorectal excision, with evidence indicating reduced intraoperative blood loss, shortened hospital stays, functional recovery. Nonetheless, challenges persist, including absence haptic feedback, prohibitive costs, steep learning curve associated systems. Despite these limitations, RACS demonstrated considerable promise sphincter-preserving function-preserving procedures, ultimately enhancing postoperative quality life. Beyond surgical field, this also investigates integration within multidisciplinary treatment strategies for CRC, context locally advanced rectal cancer. combination techniques neoadjuvant therapy immunotherapy-especially tumors characterized mismatch repair deficiency or high microsatellite instability notable clinical efficacy. Furthermore, emerging personalized therapeutic approaches, immunotherapies targeted chemotherapeutic agents, emphasize transformative potential delivering oncologic outcomes. Looking towards future, innovations imaging, artificial intelligence, augmented reality, herald new possibilities further efficacy surgeries. standardization protocols, alongside ongoing training robust research, will be fully realizing benefits across diverse settings. By incorporating cutting-edge technologies methods, is prepared become future management, significantly improve both survival patient

Язык: Английский

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Integrating network pharmacology and computational biology to propose Yiqi Sanjie formula’s mechanisms in treating NSCLC: molecular docking, ADMET, and molecular dynamics simulation

Translational Cancer Research, Год журнала: 2024, Номер 13(7), С. 3798 - 3813

Опубликована: Июль 1, 2024

Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related deaths globally. Current treatments often do not fully meet efficacy and quality life expectations. Traditional Chinese medicine (TCM), particularly the Yiqi Sanjie formula, shows promise but lacks clear mechanistic understanding. This study addresses this gap by investigating therapeutic effects underlying mechanisms formula in NSCLC.

Язык: Английский

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Emerging treatment approaches for colorectal cancer treatment resistance

Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 107 - 145

Опубликована: Ноя. 8, 2024

Язык: Английский

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