Influence of Hypoxia on the Airway Epithelium DOI Creative Commons

K Procházková,

Jir̆ı́ Uhlı́k

Physiological Research, Год журнала: 2024, Номер unknown, С. S557 - S568

Опубликована: Ноя. 25, 2024

The necessity of oxygen for metabolic processes means that hypoxia can lead to serious cell and tissue damage. On the other hand, in some situations, occurs under physiological conditions serves as an important regulation factor. airway epithelium is specific it gains not only from blood supply but also directly luminal air. Many respiratory diseases are associated with obstruction or excessive mucus production thus leading hypoxia. main goal this review point out how reacts hypoxic conditions. Cells detect low levels using molecular mechanisms involving hypoxia-inducible factors (HIFs). In addition, cells appear overexpress HIFs then regulate many aspects epithelial functions. effects include secretory stimulation hyperplasia, barrier changes, ciliogenesis impairment. All changes impair mucociliary clearance, exacerbate infection, promote inflammation damage subsequent wall remodeling. modulation regulatory may be one strategies treatment obstructive hyperproduction. Keywords: Secretory cells, Motile cilia, Epithelial barrier, Oxygenation, Obstructive diseases.

Язык: Английский

CX3CL1 (Fractalkine)-CX3CR1 Axis in Inflammation-Induced Angiogenesis and Tumorigenesis DOI Open Access
Dariusz Szukiewicz

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(9), С. 4679 - 4679

Опубликована: Апрель 25, 2024

The chemotactic cytokine fractalkine (FKN, chemokine CX3CL1) has unique properties resulting from the combination of chemoattractants and adhesion molecules. soluble form (sFKN) strongly attracts T cells monocytes. membrane-bound (mFKN) facilitates diapedesis is responsible for cell-to-cell adhesion, especially by promoting strong leukocytes (monocytes) to activated endothelial with subsequent formation an extracellular matrix angiogenesis. FKN signaling occurs via CX3CR1, which only known member CX3C receptor subfamily. Signaling within FKN-CX3CR1 axis plays important role in many processes related inflammation immune response, often occur simultaneously overlap. upregulated hypoxia and/or inflammation-induced inflammatory release, it may act locally as a key angiogenic factor highly hypoxic tumor microenvironment. importance FKN/CX3CR1 pathway tumorigenesis cancer metastasis results its influence on cell apoptosis, migration. This review presents context angiogenesis cancer. mechanisms determining pro- or anti-tumor effects are presented, cause seemingly contradictory that create confusion regarding therapeutic goals.

Язык: Английский

Процитировано

15
Optimizing brain protection after cardiac arrest: advanced strategies and best practices DOI

Ida Giorgia Iavarone,

Katia Donadello, Gianmaria Cammarota

и другие.

Interface Focus, Год журнала: 2024, Номер 14(6)

Опубликована: Дек. 6, 2024

Cardiac arrest (CA) is associated with high incidence and mortality rates. Among patients who survive the acute phase, brain injury stands out as a primary cause of death or disability. Effective intensive care management, including targeted temperature seizure treatment maintenance normal physiological parameters, plays crucial role in improving survival neurological outcomes. Current guidelines advocate for neuroprotective strategies to mitigate secondary following CA, although certain treatments remain subjects debate. Clinical examination neuroimaging studies, both invasive non-invasive neuromonitoring methods serum biomarkers are valuable tools predicting outcomes comatose resuscitated patients. Neuromonitoring, particular, provides vital insights identifying complications, personalizing approaches forecasting prognosis post-CA. In this review, we offer an overview advanced best practices aimed at optimizing protection after CA.

Язык: Английский

Процитировано

2
Redox signaling in regenerative medicine: Regulatory mechanisms and therapeutic implications DOI
Ali Mohammad Sharifi,

M. Amin Sharifi,

Tunku Kamarul

и другие.

Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 1 - 33

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

0
Nitidine Chloride Alleviates Hypoxic Stress via PINK1-Parkin-Mediated Mitophagy in the Mammary Epithelial Cells of Milk Buffalo DOI Creative Commons
Zhiwei Kong,

Hong Pan,

Zi Wang

и другие.

Animals, Год журнала: 2024, Номер 14(20), С. 3016 - 3016

Опубликована: Окт. 18, 2024

Hypoxia in the mammary gland epithelial cells of milk buffalo (BMECs) can affect yield and composition, it even cause metabolic diseases. Nitidine chloride (NC) is a natural alkaloid with antioxidant properties that scavenge excessive reactive oxygen species (ROS). However, effect NC on hypoxic injury BMECs its molecular mechanisms are still unknown. Here, an immunofluorescence assay, transmission electron microscopy (TEM), flow cytometry, combined untargeted metabolomics, were used to investigate protective stress BMECs. It was found significantly reduce cell activity (p < 0.05) inhibit cellular oxidative apoptosis 0.05). A significant decrease mitophagy mediated by PINK1-Parkin pathway observed after pretreatment In addition, enrichment analysis demonstrated against may be related downregulation pathways involving aminoacyl tRNA biosynthesis; arginine proline metabolism; glycine, serine, threonine phenylalanine, tyrosine, tryptophan phenylalanine metabolism. Thus, has mitochondria, regulate amino acid metabolism response stress. The present study provides reference for application nitidine lactation function buffalo.

Язык: Английский

Процитировано

0
Hypoxia and collagen deposition in the kidneys infected with Acanthamoeba sp. DOI Creative Commons
Karolina Kot, Marta Grabowska, Maciej Tarnowski

и другие.

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Ноя. 15, 2024

Abstract Acanthamoeba spp. are facultative, opportunistic pathogens that found in diverse environments. In the hosts, they lead to multi-organ disease. Recent studies reported may induce changes kidneys of hosts. The aim study was determine influence sp. on hypoxia and collagen deposition immunocompetent immunosuppressed mice infected with results strongly suggest induces normal reduced immune response by increasing gene and/or protein expression HIF1α as well HIF2α. Additionally, activation these factors is probably induced via NOX2/ROS. Hypoxia promotes vessel formation, we angiogenesis occurs parasite regardless their immunological status. proangiogenic released hypoxic conditions cause modulation inflammation kidney cells, which turn leads TGF-β. This work reveals mechanisms occurring hosts sp., highlights supports relevance pathophysiology systematic acanthamoebiasis.

Язык: Английский

Процитировано

0
Influence of Hypoxia on the Airway Epithelium DOI Creative Commons

K Procházková,

Jir̆ı́ Uhlı́k

Physiological Research, Год журнала: 2024, Номер unknown, С. S557 - S568

Опубликована: Ноя. 25, 2024

The necessity of oxygen for metabolic processes means that hypoxia can lead to serious cell and tissue damage. On the other hand, in some situations, occurs under physiological conditions serves as an important regulation factor. airway epithelium is specific it gains not only from blood supply but also directly luminal air. Many respiratory diseases are associated with obstruction or excessive mucus production thus leading hypoxia. main goal this review point out how reacts hypoxic conditions. Cells detect low levels using molecular mechanisms involving hypoxia-inducible factors (HIFs). In addition, cells appear overexpress HIFs then regulate many aspects epithelial functions. effects include secretory stimulation hyperplasia, barrier changes, ciliogenesis impairment. All changes impair mucociliary clearance, exacerbate infection, promote inflammation damage subsequent wall remodeling. modulation regulatory may be one strategies treatment obstructive hyperproduction. Keywords: Secretory cells, Motile cilia, Epithelial barrier, Oxygenation, Obstructive diseases.

Язык: Английский

Процитировано

0