Pathogenesis and Key Cells in Allergic Rhinitis DOI
Yu-Zhu He, Yuxiang Chen, Shuang Xu

и другие.

International Archives of Allergy and Immunology, Год журнала: 2024, Номер unknown, С. 1 - 12

Опубликована: Ноя. 19, 2024

Background: Allergic rhinitis (AR) is one of the most common chronic diseases worldwide, with prevalence rates as high 50% in high-income countries. Patients AR often have symptoms such runny nose, itchy nasal congestion, sneezing, and signs edema pallor mucosa, these pathologies a major impact on patient’s learning, sleep, quality life, resulting significant pain huge economic burden for patient. Summary: Among current treatments AR, immunotherapy able to achieve satisfactory clinical outcomes. This shows importance immune cells AR. However, therapies do not provide complete cure The reason this that research focuses mechanism Th1 Th2 ignoring role other key Key Messages: Group 2 innate lymphoid cells, B T macrophages can play pathogenesis by producing appropriate cytokines mediating inflammatory response. M2 promote eosinophils enhance type response further

Язык: Английский

The NLRP3 inflammasome in allergic diseases: mechanisms and therapeutic implications DOI Creative Commons
Huiqin Zhou, Li Wang, Wei Lv

и другие.

Clinical and Experimental Medicine, Год журнала: 2024, Номер 24(1)

Опубликована: Сен. 26, 2024

In recent years, there has been a global increase in the prevalence of allergic diseases, including rhinitis, chronic rhinosinusitis, asthma, atopic dermatitis, conjunctivitis, and food allergies. Since pathogenic mechanisms these diseases are not yet fully understood, targeted effective therapies lacking. The NLRP3 inflammasome, multiprotein complex implicated various inflammatory can be activated by diverse stimuli. It assembles into inflammasome complexes through conformational changes, initiating proteolytic cleavage dormant procaspase-1 active caspase-1 promoting maturation cytokines, IL-1β IL-18. Dysfunction may serve as key driver leading to pyroptosis amplifying local response. As preliminarily demonstrated, specific vesicle inhibitors play refectory roles animal models it is believed that potential therapeutic agents for diseases. This review highlights progress research on explores its contribution different types identifies promising clinical targets intervention.

Язык: Английский

Процитировано

6
Unraveling the role of NLRP3 inflammasome in allergic inflammation: implications for novel therapies DOI Creative Commons
Hui-Fei Lu,

Yi-Chi Zhou,

Tianyong Hu

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Июль 26, 2024

Allergic diseases like asthma, allergic rhinitis and dermatitis pose a significant global health burden, driving the search for novel therapies. The NLRP3 inflammasome, key component of innate immune system, is implicated in various inflammatory diseases. Upon exposure to allergens, undergoes two-step activation process (priming assembly) form active inflammasomes. These inflammasomes trigger caspase-1 activation, leading cleavage pro-inflammatory cytokines (IL-1β IL-18) GSDMD. This induces pyroptosis amplifies inflammation. Recent studies humans mice strongly suggest link between IL-1β, IL-18, development However, further research needed fully understand NLRP3's specific mechanisms allergies. review aims summarize latest advances regulation. We will discuss small molecule drugs natural products targeting as potential therapeutic strategies

Язык: Английский

Процитировано

5
Correlation and diagnostic significance of CD4 T cell subsets and NLRP3 inflammasome in ulcerative colitis: the role of the NLRP3/T-bet/GATA3 axis DOI Creative Commons

Yingnan Hu,

Jingyi Tang, Dian Yu

и другие.

BMC Gastroenterology, Год журнала: 2025, Номер 25(1)

Опубликована: Янв. 21, 2025

Abstract Background and aim Ulcerative colitis (UC) is characterized by complex immunological interactions involving CD4 T cell subsets the NLRP3 inflammasome, which influence inflammatory responses. This investigation focused on delineating activation profiles of these components their correlation with disease severity activity, assessing diagnostic implications in UC. Methods We conducted immunohistochemistry ELISA assays to measure markers expression inflammasome UC patients versus controls. Findings were validated using analysis, molecular docking ROC curves. Results displayed increased Th1 (T-bet, TNF-α), Th2 (GATA3, IL-6), Th17 (RORγt, IL-17, IL-22, IL-23) Additionally, cytokines (IL-2 IL-4) significantly elevated severe UC, while Treg (FOXP3, IL-10, TGF-β1) only mild-to-moderate Enhanced activation, indicated NLRP3, Caspase-1, IL-1β levels. These patterns, confirmed through analysis docking, underscored strong correlations among T-bet, GATA3, supporting proposed NLRP3/T-bet/GATA3 axis. axis, along other biomarkers, showed associations severity, Mayo score, UCEIS, demonstrated relatively high value. Conclusion The axis provides a referable strategy for multi-targeted combined treatment may serve as potential biomarkers enhancing accuracy guiding therapy.

Язык: Английский

Процитировано

0
Serum Soluble Fibrinogen-Like Protein 2 Estimates Increased T-Helper 2 Cytokine, Elevated Disease Severity, and Unfavorable Outcomes in Allergic Rhinitis Patients DOI Creative Commons

Xiaoqiong Qian,

Danping Li, Yu Zhang

и другие.

Annals of Otology Rhinology & Laryngology, Год журнала: 2024, Номер unknown

Опубликована: Дек. 17, 2024

Soluble fibrinogen-like protein 2 (sFGL2) may be involved in the pathology and progression of allergic rhinitis (AR) through regulating T-helper (Th)2 cell response. This study aimed to explore ability sFGL2 estimate outcomes AR patients.

Язык: Английский

Процитировано

1
Isoorientin alleviates ovalbumin-stimulated allergic rhinitis in mice by restoring Th1/Th2 balance DOI Open Access

Jianyi H. Huang,

Ran Ji,

Xueshen Qian

и другие.

Allergologia et Immunopathologia, Год журнала: 2024, Номер 52(5), С. 29 - 35

Опубликована: Сен. 1, 2024

Allergic rhinitis (AR) is a chronic, non-infectious inflammatory condition of the nasal mucosa mediated by IgE. There need for development novel medications to treat this ailment. Isoorientin naturally occurring flavonoid that possesses antioxidant, anti--inflammatory, and various other advantageous characteristics. However, its potential effects on AR remain unclear. This study evaluates therapeutic isoorientin ovalbumin (OVA)-induced allergic in mice explores underlying mechanism. Our revealed administration effectively decreased frequency nose rubbing sneezing mice. The groups treated with showed significant decrease serum levels IgE histamine, reductions 40% 30%, respectively. ameliorated inflammation restored Th1/Th2 balance. In addition, inhibited activation NF-κB pathway tissues. summary, alleviates OVA-stimulated restoring balance blocking pathway. Thus, exhibits promise as natural agent rhinitis.

Язык: Английский

Процитировано

0
Pathogenesis and Key Cells in Allergic Rhinitis DOI
Yu-Zhu He, Yuxiang Chen, Shuang Xu

и другие.

International Archives of Allergy and Immunology, Год журнала: 2024, Номер unknown, С. 1 - 12

Опубликована: Ноя. 19, 2024

Background: Allergic rhinitis (AR) is one of the most common chronic diseases worldwide, with prevalence rates as high 50% in high-income countries. Patients AR often have symptoms such runny nose, itchy nasal congestion, sneezing, and signs edema pallor mucosa, these pathologies a major impact on patient’s learning, sleep, quality life, resulting significant pain huge economic burden for patient. Summary: Among current treatments AR, immunotherapy able to achieve satisfactory clinical outcomes. This shows importance immune cells AR. However, therapies do not provide complete cure The reason this that research focuses mechanism Th1 Th2 ignoring role other key Key Messages: Group 2 innate lymphoid cells, B T macrophages can play pathogenesis by producing appropriate cytokines mediating inflammatory response. M2 promote eosinophils enhance type response further

Язык: Английский

Процитировано

0