Network Pharmacology and Bioinformatics Study of Six Medicinal Food Homologous Plants Against Colorectal Cancer

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(3), С. 930 - 930

Опубликована: Янв. 23, 2025

Integrating network pharmacological analysis and bioinformatic techniques, this study systematically investigated the molecular mechanisms of six medicinal food homologous plants (Astragalus membranaceus, Ganoderma lucidum, Dioscorea opposite, Curcuma longa, Glycyrrhiza uralensis, Pueraria lobata) against colorectal cancer. Through screening TCMSP database, 303 active compounds 453 drug targets were identified. By integrating differential expression gene with WGCNA on GSE41258 dataset from GEO 49 potential therapeutic GO KEGG enrichment analyses demonstrated that these are primarily involved in response, fatty acid metabolism, key cancer-related pathways. Cross-validation using three machine learning algorithms—LASSO regression, SVM-RFE, Random Forest—pinpointed four critical target genes: CA1, CCND1, CXCL2, EIF6. Further, CIBERSORT immune infiltration revealed strong associations between core genes tumor microenvironment cancer patients, notably modulating M0 macrophage mast cell activity. Molecular docking confirmed robust binding interactions proteins. This elucidated cancer, providing scientific evidence for their rational clinical application.

Язык: Английский

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In silico and animal studies on the anti-cancer mechanisms of Shaoyao Decoction against colitis-associated colorectal cancer

Journal of Ethnopharmacology, Год журнала: 2025, Номер unknown, С. 119444 - 119444

Опубликована: Фев. 1, 2025

Язык: Английский

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MOLECULAR MECHANISM AND THERAPEUTIC POTENTIAL OF BERBERINE, BAICALEIN, ORIDONIN IN THE TREATMENT OF COLORECTAL CANCER – A REVIEW

Asian Journal of Pharmaceutical and Clinical Research, Год журнала: 2025, Номер unknown, С. 31 - 43

Опубликована: Апрель 7, 2025

The aim of this research is to assess the effect berberine and baicalein oridonin (ORI) treatment on colorectal cancer (CRC) cells. examines how these compounds bring about cellular alterations, stop cell cycle progression, trigger death. cancer-fighting agents together with ORI demonstrate strong anticancer properties against CRC tissues through metabolic instability arrest leading apoptosis. affects activation TP53/TCF4 mechanisms which creates endoplasmic reticulum stress then leads higher reactive oxygen species production alongside calcium ion imbalances. retinoid X receptor alpha mechanism performs better than in colon growth inhibition. Berberine suppresses progression its ability influence transforming factor-beta signaling pathway inhibitory action epithelial-mesenchymal transition weakening liver metastasis. altered composition gut microbes reduces tissue tumorigenesis as well total microbial abundance. shows anti-metastatic capabilities by blocking actions matrix metallopeptidase (MMP)-2 MMP-9 enzymes play important roles cells spreading during suppression occurs berberine-mediated G2/M death that results cyclin B1 cdc2 cdc25c protein downregulation. anti-inflammatory agent acts a major element developing tumorous lesions associated colitis. compound speeds up phase role regulating toll-like 4/nuclear factor-kappa B HT-29 regulatory process decrease stems from inflammation while also restricting multiplication.

Язык: Английский

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Cancer chemoprevention: signaling pathways and strategic approaches

Signal Transduction and Targeted Therapy, Год журнала: 2025, Номер 10(1)

Опубликована: Апрель 17, 2025

Abstract Although cancer chemopreventive agents have been confirmed to effectively protect high-risk populations from invasion or recurrence, only over ten drugs approved by the U.S. Food and Drug Administration. Therefore, screening potent is crucial reduce constantly increasing incidence mortality rate of cancer. Considering lengthy prevention process, an ideal agent should be nontoxic, inexpensive, oral. Natural compounds become a natural treasure reservoir for chemoprevention because their superior ease availability, cost-effectiveness, safety. The benefits as in various studies. In light this, present review intended fully delineate entire scope chemoprevention, primarily focuses on aspects based compounds, specifically focusing mechanism action prevention, discussing detail how they exert effects affecting classical signaling pathways, immune checkpoints, gut microbiome. We also introduce novel strategies summarize role improving chemotherapy regimens. Furthermore, we describe discovering anticancer with low abundance high activity, revealing broad prospects drug discovery chemoprevention. Moreover, associate precision medicine, discuss challenges encountered Finally, emphasize transformative potential advancing field ability more effective less toxic preventive options oncology.

Язык: Английский

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Berberine sensitizes immune checkpoint blockade therapy in melanoma by NQO1 inhibition and ROS activation

International Immunopharmacology, Год журнала: 2024, Номер 142, С. 113031 - 113031

Опубликована: Авг. 31, 2024

Язык: Английский

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Research Progress of Berberine in Treatment of Intestinal Diseases

Advances in Clinical Medicine, Год журнала: 2024, Номер 14(11), С. 15 - 20

Опубликована: Янв. 1, 2024

Язык: Английский

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Research Progress on the Relationship between Intestinal Flora and Gastrointestinal Malignancy

Advances in Clinical Medicine, Год журнала: 2024, Номер 14(11), С. 262 - 268

Опубликована: Янв. 1, 2024

Язык: Английский

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Network pharmacology and anticancer mechanism study of Dendrobium nobile dendrobine in the treatment of colorectal cancer

Discover Oncology, Год журнала: 2024, Номер 15(1)

Опубликована: Дек. 18, 2024

This study aims to explore the potential targets and anticancer mechanisms of dendrobine from Dendrobium nobile in treatment colorectal cancer through network pharmacology, experimentally validate its specific effects.

Язык: Английский

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