Ferritinophagy: a possible new iron-related metabolic target in canine osteoblastic osteosarcoma

Frontiers in Veterinary Science, Год журнала: 2025, Номер 12

Опубликована: Март 24, 2025

Canine osteosarcomas (COS) are the most common bone tumors in dogs, characterized by high metastatic rates, poor prognosis, and responsiveness to routine therapies, which highlights need for new treatment targets. In this context, metabolism of neoplastic cells represents an increasingly studied element, as cancer depend on particular metabolic pathways that also elements vulnerability. Among these, tumor (TCs) show higher iron requirements sustain proliferation (so-called addiction), achieved increasing uptake and/or activating ferritinophagy, a process mediated Nuclear receptor Co-Activator 4 (NCOA4) leading mobilization from ferritin (Ft) deposits. Previous studies have shown COS overexpress Transferrin Receptor 1 (TfR1) increase uptake. study we evaluated immunohistochemical expression ferritinophagy-related proteins, namely Ferritin Heavy chain (FTH1) NCOA4, proliferating cell nuclear antigen (PCNA) canine normal osteoblastic osteosarcoma (COOS) samples. Normal samples revealed negative/weak immunoreactivity FTH1, NCOA4 PCNA <10% osteocytes. COOS majority showed PCNA. Our data suggest activation ferritinophagy responds feed their “iron addiction.” These data, though preliminary, further targeting potential strategy worthy be transferred into clinical practice.

Язык: Английский

Based on single-cell and transcriptome data, ferroptosis and the immunological landscape in osteosarcoma were discovered

Discover Oncology, Год журнала: 2025, Номер 16(1)

Опубликована: Апрель 29, 2025

Язык: Английский