The pathogenesis and targeted therapies of intervertebral disc degeneration induced by cartilage endplate inflammation DOI Creative Commons
Haiyan Yang, Xiaoyan Chen, Jun Chen

и другие.

Frontiers in Cell and Developmental Biology, Год журнала: 2024, Номер 12

Опубликована: Дек. 2, 2024

Intervertebral disc degeneration (IVDD) is the leading cause of low back pain, where and death nucleus pulposus cells within intervertebral (IVD) can be obviously revealed. This result in an imbalance extracellular matrix due to loss proteoglycans water content, which further lead catabolic anabolic dysfunction IVD. Recently, cartilage endplate (CEP) during aging has drawn large attention its essential functions contributing nutrient exchange maintaining IVD homeostasis. Furthermore, inflammation disturbed homeostasis CEP not only accelerate degradation matrix, but also exacerbate IVDD by causing cell through other pathological factors. Here this review, we summarized possible factors underlying mechanisms inflammation-induced IVDD, including exosomes degeneration, calcification, ferroptosis, mechanical changes, senescence. Besides, changes miRNAs, pain-related neural reflex arc pathways associated with are reviewed. In addition, new strategies specifically designed for discussed last section. We hope paper offer some insights advancing novel treating serve as a valuable reference researchers field.

Язык: Английский

The protective effect and experimental research progress of pleotropic statins in intervertebral disc degeneration DOI Creative Commons
Xianxu Zhang, Shicheng Li, Xin Liu

и другие.

Journal of Orthopaedic Surgery and Research, Год журнала: 2025, Номер 20(1)

Опубликована: Янв. 31, 2025

Язык: Английский

Процитировано

0
The pathogenesis and targeted therapies of intervertebral disc degeneration induced by cartilage endplate inflammation DOI Creative Commons
Haiyan Yang, Xiaoyan Chen, Jun Chen

и другие.

Frontiers in Cell and Developmental Biology, Год журнала: 2024, Номер 12

Опубликована: Дек. 2, 2024

Intervertebral disc degeneration (IVDD) is the leading cause of low back pain, where and death nucleus pulposus cells within intervertebral (IVD) can be obviously revealed. This result in an imbalance extracellular matrix due to loss proteoglycans water content, which further lead catabolic anabolic dysfunction IVD. Recently, cartilage endplate (CEP) during aging has drawn large attention its essential functions contributing nutrient exchange maintaining IVD homeostasis. Furthermore, inflammation disturbed homeostasis CEP not only accelerate degradation matrix, but also exacerbate IVDD by causing cell through other pathological factors. Here this review, we summarized possible factors underlying mechanisms inflammation-induced IVDD, including exosomes degeneration, calcification, ferroptosis, mechanical changes, senescence. Besides, changes miRNAs, pain-related neural reflex arc pathways associated with are reviewed. In addition, new strategies specifically designed for discussed last section. We hope paper offer some insights advancing novel treating serve as a valuable reference researchers field.

Язык: Английский

Процитировано

2