A heme-dependent enzyme forms the hydrazine in the antibiotic negamycin DOI
Menghua Wang, Zi-Wang Wei, Katherine S. Ryan

и другие.

Nature Chemical Biology, Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

Язык: Английский

Enzymatic synthesis of azide by a promiscuous N-nitrosylase DOI
Antonio Del Rio Flores, Rui Zhai, David W. Kastner

и другие.

Nature Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Сен. 27, 2024

Язык: Английский

Процитировано

7

Recent Developments and Challenges in the Enzymatic Formation of Nitrogen–Nitrogen Bonds DOI Creative Commons

Charitomeni Angeli,

Sara Atienza-Sanz, Simon Schröder

и другие.

ACS Catalysis, Год журнала: 2024, Номер 15(1), С. 310 - 342

Опубликована: Дек. 17, 2024

The biological formation of nitrogen–nitrogen (N–N) bonds represents intriguing reactions that have attracted much attention in the past decade. This interest has led to an increasing number N–N bond-containing natural products (NPs) and related enzymes catalyze their (referred this review as NNzymes) being elucidated studied greater detail. While more detailed information on biosynthesis NPs, which only become available recent years, provides unprecedented source biosynthetic enzymes, potential for biocatalytic applications been minimally explored. With review, we aim not provide a comprehensive overview both characterized NNzymes hypothetical biocatalysts with putative bond forming activity, but also highlight from perspective. We present compare conventional synthetic approaches linear cyclic hydrazines, hydrazides, diazo- nitroso-groups, triazenes, triazoles allow comparison enzymatic routes via these functional groups. Moreover, pathways well diversity reaction mechanisms are presented according direct groups currently accessible enzymes.

Язык: Английский

Процитировано

3

Exquisite Complex Reaction Cascade in the Natural 1,2,4-Triazine Assembly DOI

Yiyuan Cheng,

Haoran Pang, Wenjun Zhang

и другие.

Journal of the American Chemical Society, Год журнала: 2025, Номер unknown

Опубликована: Март 29, 2025

1,2,4-Triazine ring is a scaffold widely found in biologically active compounds, but how nature makes it remains enigmatic. In this study, we unveil the complex enzymatic and nonenzymatic cascade reactions that assemble 1,2,4-triazine moiety structures of natural products pseudoiodinine toxoflavin. Through biochemical studies, isotope labeling, application substrate analogues, propose plausible pathway for assembly from common precursor riboflavin biosynthesis. This process involves four two-electron oxidation steps, C-N bond formation, decarboxylation, N-N forming step catalyzed by metal-dependent WD40-repeat (WDR) protein. study thus not only provides first biocatalytic route also identifies previously unrecognized catalytic role large WDR protein family.

Язык: Английский

Процитировано

0

A heme-dependent enzyme forms the hydrazine in the antibiotic negamycin DOI
Menghua Wang, Zi-Wang Wei, Katherine S. Ryan

и другие.

Nature Chemical Biology, Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0