IR820 Sensitized Ceria Nanozyme via PDA Bridging for Multifaceted Antibacterial Wound Healing Therapy DOI Open Access
Akram Nasser Juaim, Jiao Sun, Ran Nie

и другие.

Small, Год журнала: 2025, Номер unknown

Опубликована: Март 31, 2025

Nanozymes with peroxidase (POD)-like activity hold significant potential for addressing antibiotic-resistant bacterial infections. However, their catalytic efficiency and therapeutic efficacy need further improvement to broaden clinical applications. A key challenge is achieving efficient energy transfer from photosensitizing molecules nanozymes, which critical enhancing performance. In this study, a universal strategy developed bridge nanozymes molecules, designing photoactivated called IR820/PDA@mCeO2 (IR/P@Ce). By integrating IR820, photosensitizer, mesoporous ceria (mCeO2), it facilitates electron through polydopamine (PDA) resulting in enhanced POD-like performance reactive oxygen species production. Additionally, PDA stabilized the nanozyme, improved photothermal therapy, photodynamic therapy under near-infrared light exposure, amplifying destruction. This multifunctional nanozyme demonstrated strong antibacterial against both Gram-positive (Staphylococcus aureus) Gram-negative (Escherichia coli) bacteria. Moreover, its synergistic approach not only facilitated eradication but also accelerated wound healing vivo, making promising alternative managing infections promoting tissue regeneration.

Язык: Английский

IR820 Sensitized Ceria Nanozyme via PDA Bridging for Multifaceted Antibacterial Wound Healing Therapy DOI Open Access
Akram Nasser Juaim, Jiao Sun, Ran Nie

и другие.

Small, Год журнала: 2025, Номер unknown

Опубликована: Март 31, 2025

Nanozymes with peroxidase (POD)-like activity hold significant potential for addressing antibiotic-resistant bacterial infections. However, their catalytic efficiency and therapeutic efficacy need further improvement to broaden clinical applications. A key challenge is achieving efficient energy transfer from photosensitizing molecules nanozymes, which critical enhancing performance. In this study, a universal strategy developed bridge nanozymes molecules, designing photoactivated called IR820/PDA@mCeO2 (IR/P@Ce). By integrating IR820, photosensitizer, mesoporous ceria (mCeO2), it facilitates electron through polydopamine (PDA) resulting in enhanced POD-like performance reactive oxygen species production. Additionally, PDA stabilized the nanozyme, improved photothermal therapy, photodynamic therapy under near-infrared light exposure, amplifying destruction. This multifunctional nanozyme demonstrated strong antibacterial against both Gram-positive (Staphylococcus aureus) Gram-negative (Escherichia coli) bacteria. Moreover, its synergistic approach not only facilitated eradication but also accelerated wound healing vivo, making promising alternative managing infections promoting tissue regeneration.

Язык: Английский

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