Cell Biology International, Год журнала: 2025, Номер unknown

Опубликована: Март 18, 2025

ABSTRACT Piwei Peiyuan (PWPY) prescription is a traditional Chinese medicine and has been efficiently used in the clinics to treat chronic atrophic gastritis (CAG) for many years. However, mechanism of action underlying PWPY treating CAG remains elusive. A rat animal cell model was constructed this study explore CAG. Here we show that attenuates progression by eliciting MAPK10‐mediated mitochondrial autophagy. Experimental introduced using N ‐methyl‐n'‐nitro‐n‐nitroguanidine (MNNG). Our histological analyses reveal MNNG‐induced undergoes classical morphological alterations judged immunohistochemistry serum level PGⅠ, PGⅡ, G17. Importantly, treatment prevents Interestingly, inhibits MAPK10 activity biochemical assays promotes autophagy electron microscopic analyses. Thus, conclude precancerous lesions harnessing MAPK10‐elicited The experimental provides robust platform further delineating therapeutic targets regimen.

Язык: Английский