Unified Hydrogen Atom Transfer Approach To Construct Vicinal Functionality

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Фев. 6, 2025

Due to their prevalence in pharmaceuticals and natural products, vicinally functionalized motifs are highly sought-after. Traditionally, these fragments synthesized from alkene precursors via oxidation reactions. However, complementary syntheses a C–C bond-forming approach underexplored. Herein, we disclose unified for accessing by acetal reagents made affordable, prefunctionalized starting materials. We have demonstrated the wide applicability of this methodology variety molecularly complex substrates. Additionally, coupled products can be employed one-pot cyclizations synthesize lactones.

Язык: Английский

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Metallaphotocatalytic modular synthesis of masked arylaminomethyl trifluoromethyl ketones

Cell Reports Physical Science, Год журнала: 2025, Номер unknown, С. 102564 - 102564

Опубликована: Апрель 1, 2025

Язык: Английский

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Chromium(II)-Catalyzed Defluorinative Reductive Cross-Coupling of Acetals with α-Trifluoromethyl Alkenes

Organic & Biomolecular Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

α-Alkoxyalkyl radicals are generated from acetals by chromium catalysis. The addition of the to α-trifluoromethyl alkenes, followed β-fluoride elimination, efficiently produces gem -difluoroalkenes with a homoallylic alkoxy group.

Язык: Английский

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C–H acylation as an enabling tool to tag phenolic drugs

Organic Chemistry Frontiers, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

A Pd-catalyzed directed C–H acylation of a collection intricate phenol-containing compounds with ethanol and other alcohols aldehydes is reported.

Язык: Английский

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